Search Results - "Budd, A"

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration by Voigt, Andrew P., Mulfaul, Kelly, Mullin, Nathaniel K., Flamme-Wiese, Miles J., Giacalone, Joseph C., Stone, Edwin M., Tucker, Budd A., Scheetz, Todd E., Mullins, Robert F.

“…The human retinal pigment epithelium (RPE) and choroid are complex tissues that provide crucial support to the retina. Disease affecting either of these…”
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Molecular evidence for horizontal transmission of chelonid alphaherpesvirus 5 at green turtle (Chelonia mydas) foraging grounds in Queensland, Australia by Jones, K, Burgess, G, Budd, A M, Huerlimann, R, Mashkour, N, Ariel, E

“…Fibropapillomatosis (FP) is a marine turtle disease recognised by benign tumours on the skin, eyes, shell, oral cavity and/or viscera. Despite being a globally…”
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Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease by Stone, Edwin M., MD, PhD, Andorf, Jeaneen L., BA, Whitmore, S. Scott, PhD, DeLuca, Adam P., PhD, Giacalone, Joseph C., BS, Streb, Luan M., BA, Braun, Terry A., PhD, Mullins, Robert F., PhD, Scheetz, Todd E., PhD, Sheffield, Val C., MD, PhD, Tucker, Budd A., PhD

“…Purpose To devise a comprehensive multiplatform genetic testing strategy for inherited retinal disease and to describe its performance in 1000 consecutive…”
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Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice by Tucker, Budd A, Park, In-Hyun, Qi, Sara D, Klassen, Henry J, Jiang, Caihui, Yao, Jing, Redenti, Stephen, Daley, George Q, Young, Michael J

“…This study was designed to determine whether adult mouse induced pluripotent stem cells (iPSCs), could be used to produce retinal precursors and subsequently…”
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Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy by Whitmore, S. Scott, Sohn, Elliott H., Chirco, Kathleen R., Drack, Arlene V., Stone, Edwin M., Tucker, Budd A., Mullins, Robert F.

“…Age-related macular degeneration (AMD) is a common and devastating disease that can result in severe visual dysfunction. Over the last decade, great progress…”
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Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo by Zhu, Wei, Gramlich, Oliver W., Laboissonniere, Lauren, Jain, Ankur, Sheffield, Val C., Trimarchi, Jeffrey M., Tucker, Budd A., Kuehn, Markus H.

“…Glaucoma is a common cause of vision loss or blindness and reduction of intraocular pressure (IOP) has been proven beneficial in a large fraction of glaucoma…”
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Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma by Zhu, Wei, Jain, Ankur, Gramlich, Oliver W, Tucker, Budd A, Sheffield, Val C, Kuehn, Markus H

“…Primary open-angle glaucoma (POAG) is particularly common in older individuals and associated with pathologic degeneration of the trabecular meshwork (TM). We…”
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Two-photon polymerization for production of human iPSC-derived retinal cell grafts by Worthington, Kristan S., Wiley, Luke A., Kaalberg, Emily E., Collins, Malia M., Mullins, Robert F., Stone, Edwin M., Tucker, Budd A.

“…[Display omitted] Recent advances in induced pluripotent stem cell (iPSC) technology have paved the way for the production of patient-specific neurons that are…”
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Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration by Burnight, Erin R., Gupta, Manav, Wiley, Luke A., Anfinson, Kristin R., Tran, Audrey, Triboulet, Robinson, Hoffmann, Jeremy M., Klaahsen, Darcey L., Andorf, Jeaneen L., Jiao, Chunhua, Sohn, Elliott H., Adur, Malavika K., Ross, Jason W., Mullins, Robert F., Daley, George Q., Schlaeger, Thorsten M., Stone, Edwin M., Tucker, Budd A.

“…Patient-derived induced pluripotent stem cells (iPSCs) hold great promise for autologous cell replacement. However, for many inherited diseases, treatment will…”
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Choriocapillaris Degeneration in Geographic Atrophy by Sohn, Elliott H., Flamme-Wiese, Miles J., Whitmore, S. Scott, Workalemahu, Grefachew, Marneros, Alexander G., Boese, Erin A., Kwon, Young H., Wang, Kai, Abramoff, Michael D., Tucker, Budd A., Stone, Edwin M., Mullins, Robert F.

“…Early age-related macular degeneration (AMD) is characterized by degeneration of the choriocapillaris, the vascular supply of retinal photoreceptor cells. We…”
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Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors by Saint-Geniez, Magali, Maharaj, Arindel S R, Walshe, Tony E, Tucker, Budd A, Sekiyama, Eiichi, Kurihara, Tomoki, Darland, Diane C, Young, Michael J, D'Amore, Patricia A

“…Vascular endothelial growth factor (VEGF) is well known for its role in normal and pathologic neovascularization. However, a growing body of evidence indicates…”
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Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases by Wiley, Luke A., Burnight, Erin R., Songstad, Allison E., Drack, Arlene V., Mullins, Robert F., Stone, Edwin M., Tucker, Budd A.

“…Vision is the sense that we use to navigate the world around us. Thus it is not surprising that blindness is one of people's most feared maladies. Heritable…”
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Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa by Tucker, Budd A, Scheetz, Todd E, Mullins, Robert F, DeLuca, Adam P, Hoffmann, Jeremy M, Johnston, Rebecca M, Jacobson, Samuel G, Sheffield, Val C, Stone, Edwin M

“…Retinitis pigmentosa (RP) is a genetically heterogeneous heritable disease characterized by apoptotic death of photoreceptor cells. We used exome sequencing to…”
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The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning by Mullins, Robert F, Schoo, Desi P, Sohn, Elliott H, Flamme-Wiese, Miles J, Workamelahu, Grefachew, Johnston, Rebecca M, Wang, Kai, Tucker, Budd A, Stone, Edwin M

“…Age-related macular degeneration (AMD) is a common disease that can result in severe visual impairment. Abnormal regulation of the complement system has been…”
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Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP by Zhang, Qihong, Giacalone, Joseph C., Searby, Charles, Stone, Edwin M., Tucker, Budd A., Sheffield, Val C.

“…Retinitis pigmentosa (RP) is an inherited retinal degenerative disease with severe vision impairment leading to blindness. About 10–15% of RP cases are caused…”
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Peri‐operative neurological complications by Hood, R., Budd, A., Sorond, F. A., Hogue, C. W.

“…Summary Brain injury from cardiac surgery is an important source of patient morbidity and mortality. The relationship between risk of brain injury and advanced…”
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Transcriptomic and Chromatin Accessibility Analysis of the Human Macular and Peripheral Retinal Pigment Epithelium at the Single-Cell Level by Mullin, Nathaniel K., Voigt, Andrew P., Boese, Erin A., Liu, Xiuying, Stone, Edwin M., Tucker, Budd A., Mullins, Robert F.

“…Some human retinal diseases are characterized by pathology that is restricted to specific cell types and to specific regions of the eye. Several disease…”
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Using Stem Cells to Rebuild the Outer Neural Retina by Tucker, Budd A

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Non-exomic and synonymous variants in ABCA4 are an important cause of Stargardt disease by Braun, Terry A, Mullins, Robert F, Wagner, Alex H, Andorf, Jeaneen L, Johnston, Rebecca M, Bakall, Benjamin B, Deluca, Adam P, Fishman, Gerald A, Lam, Byron L, Weleber, Richard G, Cideciyan, Artur V, Jacobson, Samuel G, Sheffield, Val C, Tucker, Budd A, Stone, Edwin M

“…Mutations in ABCA4 cause Stargardt disease and other blinding autosomal recessive retinal disorders. However, sequencing of the complete coding sequence in…”
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Single-cell RNA sequencing in vision research: Insights into human retinal health and disease by Voigt, Andrew P., Mullin, Nathaniel K., Stone, Edwin M., Tucker, Budd A., Scheetz, Todd E., Mullins, Robert F.

“…Gene expression provides valuable insight into cell function. As such, vision researchers have frequently employed gene expression studies to better understand…”
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