Search Results - "Buday, Laszlo"

The effects of mutant Ras proteins on the cell signalome by Takács, Tamás, Kudlik, Gyöngyi, Kurilla, Anita, Szeder, Bálint, Buday, László, Vas, Virag

“…The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation. Ras is a key molecule that controls several…”
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Unveiling epithelial plasticity regulation in lung cancer: Exploring the cross-talk among Tks4 scaffold protein partners by László, Loretta, Kurilla, Anita, Tilajka, Álmos, Pancsa, Rita, Takács, Tamás, Novák, Julianna, Buday, László, Vas, Virag

“…The epithelial-to-mesenchymal transition (EMT) represents a hallmark event in the evolution of lung cancer. This work aims to study a recently described…”
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Studying the Association of TKS4 and CD2AP Scaffold Proteins and Their Implications in the Partial Epithelial–Mesenchymal Transition (EMT) Process by Kurilla, Anita, László, Loretta, Takács, Tamás, Tilajka, Álmos, Lukács, Laura, Novák, Julianna, Pancsa, Rita, Buday, László, Vas, Virág

“…Colon cancer is a leading cause of death worldwide. Identification of new molecular factors governing the invasiveness of colon cancer holds promise in…”
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The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2 by Vető, Borbála, Bojcsuk, Dóra, Bacquet, Caroline, Kiss, Judit, Sipeki, Szabolcs, Martin, Ludovic, Buday, László, Bálint, Bálint L, Arányi, Tamás

“…Hepatocyte nuclear factor 4 alpha (HNF4α) nuclear receptor is a master regulator of hepatocyte development, nutrient transport and metabolism. HNF4α is…”
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Cellular Chaperone Function of Intrinsically Disordered Dehydrin ERD14 by Murvai, Nikoletta, Kalmar, Lajos, Szabo, Beata, Schad, Eva, Micsonai, András, Kardos, József, Buday, László, Han, Kyou-Hoon, Tompa, Peter, Tantos, Agnes

“…Disordered plant chaperones play key roles in helping plants survive in harsh conditions, and they are indispensable for seeds to remain viable. Aside from…”
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Advances in Understanding TKS4 and TKS5: Molecular Scaffolds Regulating Cellular Processes from Podosome and Invadopodium Formation to Differentiation and Tissue Homeostasis by Kudlik, Gyöngyi, Takács, Tamás, Radnai, László, Kurilla, Anita, Szeder, Bálint, Koprivanacz, Kitti, Merő, Balázs L, Buday, László, Vas, Virag

“…Scaffold proteins are typically thought of as multi-domain "bridging molecules." They serve as crucial regulators of key signaling events by simultaneously…”
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EGF Regulates the Interaction of Tks4 with Src through Its SH2 and SH3 Domains by Dülk, Metta, Szeder, Bálint, Glatz, Gábor, Merő, Balázs L, Koprivanacz, Kitti, Kudlik, Gyöngyi, Vas, Virág, Sipeki, Szabolcs, Cserkaszky, Anna, Radnai, László, Buday, László

“…The nonreceptor tyrosine kinase Src is a central component of the epidermal growth factor (EGF) signaling pathway. Our group recently showed that the Frank-ter…”
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A Novel Cell-Based Model for a Rare Disease: The Tks4-KO Human Embryonic Stem Cell Line as a Frank-Ter Haar Syndrome Model System by László, Loretta, Maczelka, Hédi, Takács, Tamás, Kurilla, Anita, Tilajka, Álmos, Buday, László, Vas, Virag, Apáti, Ágota

“…Tyrosine kinase substrate with four SH3 domains (Tks4) scaffold protein plays roles in cell migration and podosome formation and regulates systemic mechanisms…”
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Contribution of Noncovalent Recognition and Reactivity to the Optimization of Covalent Inhibitors: A Case Study on KRasG12C by Péczka, Nikolett, Ranđelović, Ivan, Orgován, Zoltán, Csorba, Noémi, Egyed, Attila, Petri, László, Ábrányi-Balogh, Péter, Gadanecz, Márton, Perczel, András, Tóvári, József, Schlosser, Gitta, Takács, Tamás, Mihalovits, Levente M., Ferenczy, György G., Buday, László, Keserű, György M.

“…Covalent drugs might bear electrophiles to chemically modify their targets and have the potential to target previously undruggable proteins with high potency…”
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Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology by László, Loretta, Kurilla, Anita, Takács, Tamás, Kudlik, Gyöngyi, Koprivanacz, Kitti, Buday, László, Vas, Virag

“…The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this review, we focus on the special role of KRAS mutations in colorectal cancer…”
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Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicin-GnRH-III conjugates developed for targeted drug delivery by Schuster, Sabine, Biri-Kovács, Beáta, Szeder, Bálint, Farkas, Viktor, Buday, László, Szabó, Zsuzsanna, Halmos, Gábor, Mező, Gábor

“…Gonadotropin releasing hormone-III (GnRH-III), a native isoform of the human GnRH isolated from sea lamprey, specifically binds to GnRH receptors on cancer…”
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Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins by Bencsik, Norbert, Pusztai, Szilvia, Borbély, Sándor, Fekete, Anna, Dülk, Metta, Kis, Viktor, Pesti, Szabolcs, Vas, Virág, Szűcs, Attila, Buday, László, Schlett, Katalin

“…CASK-interactive proteins, Caskin1 and Caskin2, are multidomain neuronal scaffold proteins. Recent data from Caskin1 knockout animals indicated only a mild…”
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Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding by Ecsédi, Péter, Kiss, Bence, Gógl, Gergő, Radnai, László, Buday, László, Koprivanacz, Kitti, Liliom, Károly, Leveles, Ibolya, Vértessy, Beáta, Jeszenői, Norbert, Hetényi, Csaba, Schlosser, Gitta, Katona, Gergely, Nyitray, László

“…Annexin A2 (ANXA2) has a versatile role in membrane-associated functions including membrane aggregation, endo- and exocytosis, and it is regulated by…”
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Disordered Regions of Mixed Lineage Leukemia 4 (MLL4) Protein Are Capable of RNA Binding by Szabó, Beáta, Murvai, Nikoletta, Abukhairan, Rawan, Schád, Éva, Kardos, József, Szeder, Bálint, Buday, László, Tantos, Ágnes

“…Long non-coding RNAs (lncRNAs) are emerging as important regulators of cellular processes and are extensively involved in the development of different cancers;…”
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Characterization of the Intramolecular Interactions and Regulatory Mechanisms of the Scaffold Protein Tks4 by Merő, Balázs, Koprivanacz, Kitti, Cserkaszky, Anna, Radnai, László, Vas, Virag, Kudlik, Gyöngyi, Gógl, Gergő, Sok, Péter, Póti, Ádám L., Szeder, Bálint, Nyitray, László, Reményi, Attila, Geiszt, Miklós, Buday, László

“…The scaffold protein Tks4 is a member of the p47phox-related organizer superfamily. It plays a key role in cell motility by being essential for the formation…”
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Predictive value analysis of the interaction network of Tks4 scaffold protein in colon cancer by Tilajka, Álmos, Kurilla, Anita, László, Loretta, Lovrics, Anna, Novák, Julianna, Takács, Tamás, Buday, László, Vas, Virag

“…Colorectal carcinoma (CRC) has emerged as one of the most widespread cancers and was the third leading cause of cancer-related mortality in 2020. The role of…”
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Dynamic control of RSK complexes by phosphoswitch‐based regulation by Gógl, Gergő, Biri‐Kovács, Beáta, Póti, Ádám L., Vadászi, Henrietta, Szeder, Bálint, Bodor, Andrea, Schlosser, Gitta, Ács, András, Turiák, Lilla, Buday, László, Alexa, Anita, Nyitray, László, Reményi, Attila

“…Assembly and disassembly of protein–protein complexes needs to be dynamically controlled and phosphoswitches based on linear motifs are crucial in this…”
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Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification by Schuster, Sabine, Biri-Kovács, Beáta, Szeder, Bálint, Buday, László, Gardi, János, Szabó, Zsuzsanna, Halmos, Gábor, Mező, Gábor

“…Receptors for gonadotropin releasing hormone (GnRH) are highly expressed in various human cancers including breast, ovarian, endometrial, prostate and…”
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Structural insights into the tyrosine phosphorylation–mediated inhibition of SH3 domain–ligand interactions by Merő, Balázs, Radnai, László, Gógl, Gergő, Tőke, Orsolya, Leveles, Ibolya, Koprivanacz, Kitti, Szeder, Bálint, Dülk, Metta, Kudlik, Gyöngyi, Vas, Virág, Cserkaszky, Anna, Sipeki, Szabolcs, Nyitray, László, Vértessy, Beáta G., Buday, László

“…Src homology 3 (SH3) domains bind proline-rich linear motifs in eukaryotes. By mediating inter- and intramolecular interactions, they regulate the functions of…”
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Novel Roles of SH2 and SH3 Domains in Lipid Binding by Sipeki, Szabolcs, Koprivanacz, Kitti, Takács, Tamás, Kurilla, Anita, László, Loretta, Vas, Virag, Buday, László

“…Signal transduction, the ability of cells to perceive information from the surroundings and alter behavior in response, is an essential property of life…”
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