Search Results - "Budak, Harun"

Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters by Petkau, Nikolai, Budak, Harun, Zhou, Xunlei, Oster, Henrik, Eichele, Gregor

“…Many physiological processes exhibit circadian rhythms driven by cellular clocks composed of interlinked activating and repressing elements. To investigate…”
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Effect of a Prolonged Dietary Iron Intake on the Gene Expression and Activity of the Testicular Antioxidant Defense System in Rats by Kocpinar, Enver Fehim, Gonul Baltaci, Nurdan, Ceylan, Hamid, Kalin, Seyda Nur, Erdogan, Orhan, Budak, Harun

“…Despite the fact that iron represents a crucial element for the catalysis of many metabolic reactions, its accumulation in the cell leads to the production of…”
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Tip60 might be a candidate for the acetylation of hepatic carbonic anhydrase I and III in mice by Gönül Baltacı, Nurdan, Koçpınar, Enver Fehim, Budak, Harun

“…Background Carbonic anhydrases (CAs) play a significant role in maintaining pH balance by catalyzing the conversion of carbon dioxide to bicarbonate. The…”
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The Effects of Amoxicillin, Cefazolin, and Gentamicin Antibiotics on the Antioxidant System in Mouse Heart Tissues by Savcı, Ahmet, Koçpınar, Enver Fehim, Budak, Harun, Çiftci, Mehmet, Şişecioğlu, Melda

“…Free radicals lead to destruction in various organs of the organism. The improper use of antibiotics increases the formation of free radicals and causes…”
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A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo[S] by Şişecioğlu, Melda, Budak, Harun, Geffers, Lars, Çankaya, Murat, Çiftci, Mehmet, Thaller, Christina, Eichele, Gregor, Küfrevioğlu, Ömer İrfan, Özdemir, Hasan

“…Cholesterol and its biosynthetic pathway intermediates and derivatives are required for many developmental processes including membrane biogenesis,…”
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The sexually dimorphic adipose fin is an androgen target tissue in the brown trout (Salmo trutta fario) by Hisar, Olcay, Sönmez, Adem Yavuz, Hisar, Şükriye Aras, Budak, Harun, Gültepe, Nejdet

“…An investigation has been described on the relationship of body length, age and sex with adipose fin length and the number of androgen receptor (AR)-containing…”
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The protective effect of the cardiac thioredoxin system on the heart in the case of iron overload in mice by Altun, Sevda, Budak, Harun

“…•Iron overload causes oxidative stress-induced damage in mice.•Cardiovascular protective pathways are activated by the appropriate iron dosage.•The appropriate…”
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An analysis of expression patterns of genes encoding proteins with catalytic activities by Cankaya, Murat, Hernandez, Ana Martinez, Ciftci, Mehmet, Beydemir, Sukru, Ozdemir, Hasan, Budak, Harun, Gulcin, Ilhami, Comakli, Veysel, Emircupani, Tufan, Ekinci, Deniz, Kuzu, Muslum, Jiang, Qiuhong, Eichele, Gregor, Kufrevioglu, Omer Irfan

“…In situ hybridization (ISH) is a powerful method for visualizing gene expression patterns at the organismal level with cellular resolution. When automated, it…”
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Inhibition of thioredoxin reductase 1 by vulpinic acid suppresses the proliferation and migration of human breast carcinoma by Kalın, Şeyda Nur, Altay, Ahmet, Budak, Harun

“…AIMSIt was aimed to investigate the thioredoxin reductase 1 (TrxR1)-targeted anticancer effect of vulpinic (VA) and lecanoric (LA) acids, which are lichen…”
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Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells by Kalın, Şeyda Nur, Altay, Ahmet, Budak, Harun

“…Breast cancer represents one of the most frequently encountered cancer types among women worldwide. Thioredoxin reductase 1 (TrxR1) is a therapeutic target for…”
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Depletion of Tip60/Kat5 affects the hepatic antioxidant system in mice by Kocpinar, Enver Fehim, Baltaci, Nurdan Gonul, Akkemik, Ebru, Budak, Harun

“…Tat‐interactive protein 60 kDa (TIP60, also known as lysine acetyltransferase 5 [KAT5]) is a member of the MYST protein family with histone acetyltransferase…”
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Effect of evernic acid on human breast cancer MCF‐7 and MDA‐MB‐453 cell lines via thioredoxin reductase 1: A molecular approach by Kalın, Şeyda Nur, Altay, Ahmet, Budak, Harun

“…Thioredoxin reductase 1 (TrxR1) has emerged as an important target for anticancer drug development due to its overexpression in many human tumors including…”
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Quantitative investigation of the bacterial content of periodontal abscess samples by real-time PCR by Ergün, Ercan, Toraman, Emine, Barış, Özlem, Budak, Harun, Demir, Turgut

“…Periodontal abscesses, which are part of the acute periodontal disease group characterized by the destruction of periodontal tissue with deep periodontal…”
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Increased nociceptive sensitivity is associated with periodontal inflammation and expression of chronic pain genes in gingival tissues of male rats by Toraman, Ayşe, Toraman, Emine, Özkaraca, Mustafa, Budak, Harun

“…This study aimed to evaluate the inflammatory response, hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2), and voltage-gated potassium (Kv) 9.1…”
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Parthenolide as a potential analgesic in the treatment of paclitaxel-induced neuropathic pain: the rat modeling by Toraman, Emine, Bayram, Cemil, Sezen, Selma, Özkaraca, Mustafa, Hacımüftüoğlu, Ahmet, Budak, Harun

“…In this study, we determined the therapeutic effect of parthenolide (PTL), the active component of Tanacetum parthenium , on neuropathic pain caused by…”
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Coaction of hepatic thioredoxin and glutathione systems in iron overload‐induced oxidative stress by Sönmez Aydın, Feyza, Hukkamlı, Berna, Budak, Harun

“…In the present study, we demonstrate the coaction of thioredoxin and glutathione (GSH) systems in mouse liver against iron overload‐induced oxidative stress…”
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Amoxicillin and gentamicin antibiotics treatment adversely influence the fertility and morphology through decreasing the Dazl gene expression level and increasing the oxidative stress by Karaman, Muhammet, Budak, Harun, Çiftci, Mehmet

“…The present study was designed to explain the impact of amoxicillin, gentamicin, and cefazolin on the oxidative stress (OS) and reproductivity in the mouse…”
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Comparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress by Hukkamlı, Berna, Dağdelen, Burak, Sönmez Aydın, Feyza, Budak, Harun

“…This study was conducted to compare the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress. Increased…”
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Examining the link between dose-dependent dietary iron intake and Alzheimer’s disease through oxidative stress in the rat cortex by Ceylan, Hamid, Budak, Harun, Kocpinar, Enver Fehim, Baltaci, Nurdan Gonul, Erdogan, Orhan

“…[Display omitted] Neurodegenerative diseases such as Alzheimer's and Parkinson's disease are characterized by the progressive deterioration of the structure…”
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Diffractaic acid exerts anti-cancer effects on hepatocellular carcinoma HepG2 cells by inducing apoptosis and suppressing migration through targeting thioredoxin reductase 1 by Sulukoğlu, Emine Karaca, Günaydın, Şükran, Kalın, Şeyda Nur, Altay, Ahmet, Budak, Harun

“…Hepatocellular carcinoma (HCC) represents one of the most common malignant tumors worldwide. Due to the limited number of available drugs and their side…”
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