Search Results - "Budac, David"

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice by WALKER, Adam K, BUDAC, David P, BISULCO, Stephanie, LEE, Anna W, SMITH, Robin A, BEENDERS, Brent, KELLEY, Keith W, DANTZER, Robert

“…We have previously demonstrated that lipopolysaccharide (LPS) induces depressive-like behavior by activating indoleamine 2,3 dioxygenase (IDO; O'Connor et al,…”
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Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism by Eskelund, Amanda, Budac, David P, Sanchez, Connie, Elfving, Betina, Wegener, Gregers

“…Graphical abstract…”
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Behavioral Deficits Are Accompanied by Immunological and Neurochemical Changes in a Mouse Model for Neuropsychiatric Lupus (NP-SLE) by Li, Yan, Eskelund, Amanda R, Zhou, Hua, Budac, David P, Sánchez, Connie, Gulinello, Maria

“…Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) have been understudied compared to end-organ failure and peripheral pathology…”
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Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats by Fischer, Christina Weide, Eskelund, Amanda, Budac, David P., Tillmann, Sandra, Liebenberg, Nico, Elfving, Betina, Wegener, Gregers

“…•One week administration of IFN-α induces depression-like behaviour in the rat forced swim test.•IFN-α treatment alters brain tryptophan levels and downstream…”
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Drugs with antidepressant properties affect tryptophan metabolites differently in rodent models with depression‐like behavior by Eskelund, Amanda, Li, Yan, Budac, David P., Müller, Heidi K., Gulinello, Maria, Sanchez, Connie, Wegener, Gregers

“…The metabolism of tryptophan through kynurenine and serotonin pathways is linked to depression. Here, effects of different drugs with antidepressant properties…”
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Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain by Laumet, Geoffroy, Zhou, Wenjun, Dantzer, Robert, Edralin, Jules D., Huo, XiaoJiao, Budac, David P., O'Connor, Jason C., Lee, Anna W., Heijnen, Cobi J., Kavelaars, Annemieke

“…•Nerve injury induces depression and upregulates kynurenine 3-monoxygenase (KMO) expression and activity.•KMO is upregulated in neurons in the contralateral…”
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A rodent model of premenstrual dysphoria: Progesterone withdrawal induces depression-like behavior that is differentially sensitive to classes of antidepressants by Li, Yan, Pehrson, Alan L., Budac, David P., Sánchez, Connie, Gulinello, Maria

“…► We demonstrate depression-like behavior during progesterone withdrawal in rats. ► Depression is evident in the forced swim test, social withdrawal and…”
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Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice by Zhou, Wenjun, Dantzer, Robert, Budac, David P, Walker, Adam K, Mao-Ying, Qi-Liang, Lee, Anna W, Heijnen, Cobi J, Kavelaars, Annemieke

“…Highlights • The spared injury (SNI) model of neuropathic pain increases liver but not brain IDO1. • Spared nerve injury increases plasma kynurenine and the…”
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Age‐dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease by Mazarei, Gelareh, Budac, David P., Lu, Ge, Adomat, Hans, Tomlinson Guns, Emma S., Möller, Thomas, Leavitt, Blair R.

“…Indoleamine 2,3 dioxygenase (Ido1), the first and rate‐limiting enzyme of the kynurenine pathway (KP), is a striatally enriched gene with increased expression…”
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Quantitative analysis of lipids: a higher-throughput LC-MS/MS-based method and its comparison to ELISA by Gandhi, Adarsh S, Budac, David, Khayrullina, Tanzilya, Staal, Roland, Chandrasena, Gamini

“…Lipids such as prostaglandins, leukotrienes and thromboxanes are released as a result of an inflammatory episode in pain (central and peripheral). To measure…”
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Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism by Smagin, Gennady N., Song, Dekun, Budac, David P., Waller, Jessica A., Li, Yan, Pehrson, Alan L., Sánchez, Connie

“…Vortioxetine is a novel multimodal antidepressant that acts as a serotonin (5-HT)3, 5-HT7, and 5-HT1D receptor antagonist; 5-HT1B receptor partial agonist;…”
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Development of a Surface Plasmon Resonance Assay for the Characterization of Small-Molecule Binding Kinetics and Mechanism of Binding to Kynurenine 3-Monooxygenase by Poda, Suresh B, Kobayashi, Masakazu, Nachane, Ruta, Menon, Veena, Gandhi, Adarsh S, Budac, David P, Li, Guiying, Campbell, Brian M, Tagmose, Lena

“…Kynurenine 3-monooxygenase (KMO), a pivotal enzyme in the kynurenine pathway, was identified as a potential therapeutic target for treating neurodegenerative…”
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Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: Evidence for direct 5-HT receptor modulation by Jensen, Jesper Bornø, du Jardin, Kristian Gaarn, Song, Dekun, Budac, David, Smagin, Gennady, Sanchez, Connie, Pehrson, Alan Lars

“…Abstract Depressed patients suffer from cognitive dysfunction, including memory deficits. Acute serotonin (5-HT) depletion impairs memory and mood in…”
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Latent toxoplasmosis and psychiatric symptoms – A role of tryptophan metabolism? by Bay-Richter, Cecilie, Buttenschøn, Henriette Nørmølle, Mors, Ole, Eskelund, Amanda, Budac, David, Kærlev, Linda, Wegener, Gregers

“…Toxoplasma gondii (TOX) is a common parasite which infects approximately one third of the human population. In recent years, it has been suggested that latent…”
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33. Neuroimmune Mechanisms of Comorbid Chronic Pain and Depression by Dantzer, Robert, Zhou, Wenjun, Laumet, Geoffory, Budac, David, Lee, Anna, O’Connor, Jason, Heijnen, Cobi, Kavelaars, Annemieke

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Neuroimmune Mechanisms of Comorbid Chronic Pain and Depression by Dantzer, Robert, Zhou, Wenjun, Laumet, Geoffory, Budac, David, Lee, Anna, O’Connor, Jason, Heijnen, Cobi, Kavelaars, Annemieke

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Task- and Treatment Length-Dependent Effects of Vortioxetine on Scopolamine-Induced Cognitive Dysfunction and Hippocampal Extracellular Acetylcholine in Rats by Pehrson, Alan L, Hillhouse, Todd M, Haddjeri, Nasser, Rovera, Renaud, Porter, Joseph H, Mørk, Arne, Smagin, Gennady, Song, Dekun, Budac, David, Cajina, Manuel, Sanchez, Connie

“…Major depressive disorder (MDD) is a common psychiatric disorder that often features impairments in cognitive function, and these cognitive symptoms can be…”
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PS111. A comparative study of fluoxetine and ketamine on quinolinic acid: An in vivo study in rats by Eskelund, Amanda, Budac, David P, Sanchez, Connie, Elfving, Betina, Wegener, Gregers

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Excited-state carbon acids. Facile benzylic carbon-hydrogen bond heterolysis of suberene on photolysis in aqueous solution: a photogenerated cyclically conjugated eight .pi. electron carbanion by Budac, David, Wan, Peter

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Age‐dependent alterations of the kynurenine pathway in the YAC 128 mouse model of Huntington disease by Mazarei, Gelareh, Budac, David P., Lu, Ge, Adomat, Hans, Tomlinson Guns, Emma S., Möller, Thomas, Leavitt, Blair R.

“…Abstract Indoleamine 2,3 dioxygenase ( Ido1 ), the first and rate‐limiting enzyme of the kynurenine pathway (KP), is a striatally enriched gene with increased…”
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