Search Results - "Buckpitt, A. R."

Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice by Carratt, S.A., Morin, D., Buckpitt, A.R., Edwards, P.C., Van Winkle, L.S.

“…•mEH metabolites may not be driving the overall toxicity of NA for known tumor sites.•The mEH pathway may be partially responsible for cytotoxicity in…”
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Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma by Plopper, C. G., Joad, J. P., Miller, L. A., Schelegle, E. S., Fanucchi, M. V., Van Winkle, L. S., Tyler, N. K., Avdalovic, M. V., Evans, M. J., Lasley, W. L., Buckpitt, A. R., Pinkerton, K. E., Tarkington, B. K., Davis, S., Nishio, S. J., Gershwin, L. J., Wu, R., Hyde, D. M.

“…Summary Background The risks for infants and young children receiving inhaled corticosteroid (ICS) therapy are largely unknown. Recent clinical studies…”
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Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice by Van Winkle, L S, Buckpitt, A R, Nishio, S J, Isaac, J M, Plopper, C G

“…Clara cells, progenitors for bronchiolar epithelium, are also primary targets for metabolically activated pulmonary cytotoxicants and have an abundance of the…”
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Glutathione Depletion Is a Major Determinant of Inhaled Naphthalene Respiratory Toxicity and Naphthalene Metabolism in Mice by Phimister, A. J., Lee, M. G., Morin, D., Buckpitt, A. R., Plopper, C. G.

“…Naphthalene (NA) is metabolized to highly reactive intermediates that are primarily detoxified by conjugation to glutathione (GSH). Intraperitoneal…”
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Asthma: a comparison of animal models using stereological methods by Hyde, D. M, Miller, L. A, Schelegle, E. S, Fanucchi, M. V, Van Winkle, L. S, Tyler, N. K, Avdalovic, M. V, Evans, M. J, Kajekar, R, Buckpitt, A. R, Pinkerton, K. E, Joad, J. P, Gershwin, L. J, Wu, R, Plopper, C. G

“…* California National Primate Research Center, # Depts of Anatomy, Physiology and Cell Biology, Molecular Biosciences and Pathology, Microbiology and…”
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Relationship of Inhaled Ozone Concentration to Acute Tracheobronchial Epithelial Injury, Site-specific Ozone Dose, and Glutathione Depletion in Rhesus Monkeys by Plopper, Charles G, Hatch, Gary E, Wong, Viviana, Duan, Xiuchen, Weir, Alison J, Tarkington, Brian K, Devlin, Robert B, Becker, Suzanne, Buckpitt, A. R

“…Acute pulmonary epithelial injury produced by short-term exposure to ozone varies by site within the tracheobronchial tree. To test whether this variability is…”
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Metabolism and cytotoxicity of naphthalene and its metabolites in isolated murine Clara cells by Chichester, C H, Buckpitt, A R, Chang, A, Plopper, C G

“…Nonciliated bronchiolar epithelial (Clara) cells of mice are highly susceptible to toxicants that undergo metabolic activation, presumably because this cell…”
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Prevention of naphthalene-induced pulmonary toxicity by glutathione prodrugs: Roles for glutathione depletion in adduct formation and cell injury by Phimister, A. J., Nagasawa, H. T., Buckpitt, A. R., Plopper, C. G.

“…Naphthalene is metabolized in the lung and liver to reactive intermediates by cytochrome P450 enzymes. These reactive species deplete glutathione, covalently…”
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Early Events in Naphthalene-Induced Acute Clara Cell Toxicity . II. Comparison of Glutathione Depletion and Histopathology by Airway Location by Plopper, Charles G, Van Winkle, Laura S, Fanucchi, Michelle V, Malburg, Sonia R. C, Nishio, Susan J, Chang, Aimin, Buckpitt, Alan R

“…One of the presumed roles of intracellular glutathione (GSH) is the protection of cells from injury by reactive intermediates produced by the metabolism of…”
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Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. III. Morphometric comparison of changes in the epithelial populations of terminal bronchioles and lobar bronchi in mice, hamsters, and rats after parenteral administration of naphthalene by Plopper, C G, Macklin, J, Nishio, S J, Hyde, D M, Buckpitt, A R

“…The purpose of this study was to define, in quantitative terms, epithelial alterations produced by the cytochrome P-450-activated Clara cell cytotoxicant,…”
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Dose-dependent tolerance to ozone. IV. Site-specific elevation in antioxidant enzymes in the lungs of rats exposed for 90 days or 20 months by Plopper, C G, Duan, X, Buckpitt, A R, Pinkerton, K E

“…Ozone-induced lung injury in rats is focal, with the primary target sites being the distal trachea and the central acinus. In both area, ozone causes cellular…”
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Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization by DiMaio Knych, H.K., DeStefano Shields, C., Buckpitt, A.R., Stanley, S.D.

“…Substantial gaps exist in our knowledge of the metabolic clearance of therapeutic agents in horses. Accordingly, a cytochrome P450 monooxygenase in the 2C…”
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Elevated susceptibility to 4-ipomeanol cytotoxicity in immature Clara cells of neonatal rabbits by Plopper, C G, Weir, A J, Nishio, S J, Chang, A, Voit, M, Philpot, R M, Buckpitt, A R

“…The bronchiolar Clara cell is one of the primary targets in adult mammals for environmental contaminants metabolized by cytochrome P450 (CYP) monooxygenases…”
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Pulmonary cytochrome P-450 monooxygenase system and Clara cell differentiation in rats by Ji, C M, Cardoso, W V, Gebremichael, A, Philpot, R M, Buckpitt, A R, Plopper, C G, Pinkerton, K E

“…Because a number of studies suggest that the developmental expression of cytochrome P-450s (CYP) in Clara cells is species specific, this study was designed to…”
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Postnatal changes in the expression and distribution of pulmonary cytochrome P450 monooxygenases during Clara cell differentiation in rabbits by Plopper, C G, Weir, A J, Morin, D, Chang, A, Philpot, R M, Buckpitt, A R

“…Previous studies have indicated that both cytodifferentiation of Clara cells and the onset of pulmonary cytochrome P450 activity are postnatal events. However,…”
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Variation in antioxidant enzyme activities in anatomic subcompartments within rat and rhesus monkey lung by Duan, X, Buckpitt, A R, Plopper, C G

“…Antioxidant enzymes including catalase, superoxide dismutase, glutathione peroxidase, and glutathione S-transferases are thought to be the primary cellular…”
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Naphthalene Cytotoxicity of Differentiating Clara Cells in Neonatal Mice by Fanucchi, M.Voit, Buckpitt, Alan R., Murphy, Mary E., Plopper, Charles G.

“…Selective Clara cell injury produced by many bioactivated lung toxicants is thought to result from high levels of activating enzymes found in differentiated…”
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Species Differences in The Regio- and Stereoselectivity of 1-Nitronaphthalene Metabolism by WATT, K. C, BUCKPITT, A. R

“…1-Nitronaphthalene (1-NN) is a mutagenic nitroaromatic that has been detected in emissions from both heavy- and light-duty diesel engines, as well as in urban…”
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Site-selective differences in cytochrome P450 isoform activities: Comparison of expression in rat and rhesus monkey lung and induction in rats by CHANHUNG LEE, WATT, K. C, CHANG, A.-M, PLOPPER, C. G, BUCKPITT, A. R, PINKERTON, K. E

“…The distribution of pulmonary cytochrome P450 (P450 or CYP) isoforms has been investigated primarily in immunohistochemical studies, which are neither…”
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Characterization of the cytochrome P-450 monooxygenase system in nonciliated bronchiolar epithelial (Clara) cells isolated from mouse lung by Chichester, C H, Philpot, R M, Weir, A J, Buckpitt, A R, Plopper, C G

“…The nonciliated bronchiolar epithelial (Clara) cell of the mouse is highly susceptible to toxicants that undergo metabolic activation, presumably because this…”
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