Search Results - "Buckmaster, S."

Distinct Neuronal Coding Schemes in Memory Revealed by Selective Erasure of Fast Synchronous Synaptic Transmission by Xu, Wei, Morishita, Wade, Buckmaster, Paul S., Pang, Zhiping P., Malenka, Robert C., Südhof, Thomas C.

“…Neurons encode information by firing spikes in isolation or bursts and propagate information by spike-triggered neurotransmitter release that initiates…”
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Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy by Toyoda, Izumi, Fujita, Satoshi, Thamattoor, Ajoy K, Buckmaster, Paul S

“…Mechanisms of seizure initiation are unclear. To evaluate the possible roles of inhibitory neurons, unit recordings were obtained in the dentate gyrus, CA3,…”
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Early activation of ventral hippocampus and subiculum during spontaneous seizures in a rat model of temporal lobe epilepsy by Toyoda, Izumi, Bower, Mark R, Leyva, Fernando, Buckmaster, Paul S

“…Temporal lobe epilepsy is the most common form of epilepsy in adults. The pilocarpine-treated rat model is used frequently to investigate temporal lobe…”
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Preictal activity of subicular, CA1, and dentate gyrus principal neurons in the dorsal hippocampus before spontaneous seizures in a rat model of temporal lobe epilepsy by Fujita, Satoshi, Toyoda, Izumi, Thamattoor, Ajoy K, Buckmaster, Paul S

“…Previous studies suggest that spontaneous seizures in patients with temporal lobe epilepsy might be preceded by increased action potential firing of…”
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Reduced Inhibition of Dentate Granule Cells in a Model of Temporal Lobe Epilepsy by Kobayashi, Masayuki, Buckmaster, Paul S

“…Patients and models of temporal lobe epilepsy have fewer inhibitory interneurons in the dentate gyrus than controls, but it is unclear whether granule cell…”
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Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy by Buckmaster, Paul S, Ingram, Elizabeth A, Wen, Xiling

“…Dentate granule cell axon (mossy fiber) sprouting is a common abnormality in patients with temporal lobe epilepsy. Mossy fiber sprouting creates an aberrant…”
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Hilar somatostatin interneuron loss reduces dentate gyrus inhibition in a mouse model of temporal lobe epilepsy by Hofmann, Gabrielle, Balgooyen, Laura, Mattis, Joanna, Deisseroth, Karl, Buckmaster, Paul S.

“…Summary Objective In patients with temporal lobe epilepsy, seizures usually start in the hippocampus, and dentate granule cells are hyperexcitable…”
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Identification of new epilepsy treatments: Issues in preclinical methodology by Galanopoulou, Aristea S., Buckmaster, Paul S., Staley, Kevin J., Moshé, Solomon L., Perucca, Emilio, Engel Jr, Jerome, Löscher, Wolfgang, Noebels, Jeffrey L., Pitkänen, Asla, Stables, James, White, H. Steve, O'Brien, Terence J., Simonato for the American Epilepsy Society Basic Science Committee and the International League Against Epilepsy Working Group on Recommendations for Preclinical Epilepsy Drug Discovery, Michele

“…Summary Preclinical research has facilitated the discovery of valuable drugs for the symptomatic treatment of epilepsy. Yet, despite these therapies, seizures…”
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Hyperexcitability, Interneurons, and Loss of GABAergic Synapses in Entorhinal Cortex in a Model of Temporal Lobe Epilepsy by Kumar, Sanjay S, Buckmaster, Paul S

“…Temporal lobe epilepsy is the most common type of epilepsy in adults, and its pathophysiology remains unclear. Layer II stellate cells of the entorhinal…”
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Axon Sprouting in a Model of Temporal Lobe Epilepsy Creates a Predominantly Excitatory Feedback Circuit by Buckmaster, Paul S, Zhang, Guo Feng, Yamawaki, Ruth

“…The most common type of epilepsy in adults is temporal lobe epilepsy. After epileptogenic injuries, dentate granule cell axons (mossy fibers) sprout and form…”
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Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy by Zhang, Wei, Huguenard, John R, Buckmaster, Paul S

“…One potential mechanism of temporal lobe epilepsy is recurrent excitation of dentate granule cells through aberrant sprouting of their axons (mossy fibers),…”
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Dysfunction of the Dentate Basket Cell Circuit in a Rat Model of Temporal Lobe Epilepsy by Zhang, Wei, Buckmaster, Paul S

“…Temporal lobe epilepsy is common and difficult to treat. Reduced inhibition of dentate granule cells may contribute. Basket cells are important inhibitors of…”
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Changes in Granule Cell Firing Rates Precede Locally Recorded Spontaneous Seizures by Minutes in an Animal Model of Temporal Lobe Epilepsy by Bower, Mark R, Buckmaster, Paul S

“…1 Departments of Comparative Medicine and 2 Neurology and Neurological Sciences, Stanford University, Stanford, California Submitted 19 December 2007; accepted…”
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Surviving mossy cells enlarge and receive more excitatory synaptic input in a mouse model of temporal lobe epilepsy by Zhang, Wei, Thamattoor, Ajoy K., LeRoy, Christopher, Buckmaster, Paul S.

“…ABSTRACT Numerous hypotheses of temporal lobe epileptogenesis have been proposed, and several involve hippocampal mossy cells. Building on previous hypotheses…”
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Stress coping stimulates hippocampal neurogenesis in adult monkeys by Lyons, David M., Buckmaster, Paul S., Lee, Alex G., Wu, Christine, Mitra, Rupshi, Duffey, Lauren M., Buckmaster, Christine L., Her, Song, Patel, Paresh D., Schatzberg, Alan F., Gage, Fred

“…Coping with intermittent social stress is an essential aspect of living in complex social environments. Coping tends to counteract the deleterious effects of…”
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Mossy fiber sprouting in the dentate gyrus by Buckmaster, Paul S.

“…Summary Aberrant sprouting of granule cell axons is a common feature in temporal lobe epilepsy. An increasingly detailed picture of granule cell circuit…”
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Highly Specific Neuron Loss Preserves Lateral Inhibitory Circuits in the Dentate Gyrus of Kainate-Induced Epileptic Rats by Buckmaster, Paul S, Jongen-Relo, Ana L

“…Patients with temporal lobe epilepsy display neuron loss in the hilus of the dentate gyrus. This has been proposed to be epileptogenic by a variety of…”
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Reduced Inhibition and Increased Output of Layer II Neurons in the Medial Entorhinal Cortex in a Model of Temporal Lobe Epilepsy by Kobayashi, Masayuki, Wen, Xiling, Buckmaster, Paul S

“…Temporal lobe epilepsy is the most common type of epilepsy in adults, and its underlying mechanisms are unclear. To investigate how the medial entorhinal…”
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Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats by Buckmaster, Paul S., Dudek, F. Edward

“…We sought to describe quantitatively the morphological and functional changes that occur in the dentate gyrus of kainate‐treated rats, an experimental model of…”
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Pinniped electroencephalography: Methodology and findings in California sea lions ( Zalophus californianus ) by Williams, D Colette, Haulena, Martin, Dennison, Sophie, Waugh, Lynnette, Goldstein, Tracey, Nutter, Felicia, Bonn, Bill Van, Hoard, Vanessa, Laxer, Kenneth D, Buckmaster, Paul S, Gulland, Frances M D, Tharp, Barry

“…This study was designed to identify abnormalities in the electroencephalograms (EEGs) recorded from stranded California sea lions ( ) with suspected …”
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