Profiling vitamin D, its mediators and proinflammatory cytokines in rheumatoid arthritis: A case–control study

Profiling vitamin D, its mediators and proinflammatory cytokines in rheumatoid arthritis: A case–control study

Introduction The active form of vitamin D has immunomodulatory and anti‐inflammatory effect. Vitamin D is implicated in pathogenesis of rheumatoid arthritis (RA) and its deficiency leads to increased inflammation. Moreover, its production is dependent on concentration of calcium, phosphorus, and par...

Full description

Saved in:
Bibliographic Details
Published in:Immunity, Inflammation and Disease Vol. 10; no. 8; pp. e676 - n/a
Main Authors: Sakyi, Samuel A., Owusu‐Yeboah, Mavis, Obirikorang, Christian, Dadzie Ephraim, Richard K., Kwarteng, Alexander, Opoku, Stephen, Afranie, Bright O., Senu, Ebenezer, Boateng, Andy O., Boakye, Derrick K., Buckman, Tonnies A., Amoani, Benjamin
Format: Journal Article
Language:English
Published: England John Wiley & Sons, Inc 01-08-2022
John Wiley and Sons Inc
Wiley
Subjects:
Arthritis, Rheumatoid
Blood & organ donations
Calcium
Case-Control Studies
Creatinine
Cytokines
Disease
Enzymes
Homeostasis
Humans
Hypocalcemia
Immune system
Inflammation
Interferon-gamma
mediators of vitamin D
Original
Parathyroid Hormone
Pathogenesis
Phosphorus
proinflammatory cytokines
Proteins
R&D
Reagents
Research & development
Rheumatoid arthritis
Rheumatology
Sepsis
Teaching hospitals
Tumor Necrosis Factor-alpha
Tumor necrosis factor-TNF
Vitamin D
Vitamin deficiency
Ghana
Africa
parathyroid hormone
proinflammatory cytokines
mediators of vitamin D
rheumatoid arthritis
phosphorus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction The active form of vitamin D has immunomodulatory and anti‐inflammatory effect. Vitamin D is implicated in pathogenesis of rheumatoid arthritis (RA) and its deficiency leads to increased inflammation. Moreover, its production is dependent on concentration of calcium, phosphorus, and parathyroid hormone (PTH). Cytokines mediates inflammation in RA synovium. This study evaluated vitamin D, its mediators and proinflammatory cytokines among RA patients. Methods In a case–control study, 78 RA patients from Komfo Anokye Teaching Hospital rheumatology clinic and 60 healthy blood donors were recruited. Chemistry analyzer and enzyme‐linked immunosorbent assay kits were used to measure biochemical parameters and cytokines. Results We found significantly higher levels of interleukin (IL)‐1β, interferon gamma (IFN‐γ), and tumor necrosis factor‐α (TNF‐α) in RA patients compared with controls (p < .05). There was a significant positive correlation between intact parathyroid hormone (iPTH) and IL‐10 (r = .30, p < .05) and a negative correlation between IL‐6 (r = −0.28, p > .05), IL‐1β (r = −0.25, p > .05), TNF‐α (r = −0.26, p > .05), IFN‐γ (r = −0.24, p > .05), and iPTH. There was a significant negative correlation between IL‐1β (r = −0.33, p < .05), IFN‐ γ (r = −0.29, p < .05), and calcium. Conclusion Reduced PTH, calcium, and phosphorus is associated with higher levels of proinflammatory cytokines which may worsen RA disease condition. Vitamin D is therefore not an independent regulator of proinflammatory cytokines in RA. The primary role of vitamin D has been established in mineral homeostasis, however, its production is dependent on serum concentration of calcium, phosphorus and parathyroid hormone. We found significantly higher levels of proinflammatory cytokines in RA patients compared with the healthy controls. A negative correlation was found between the proinflammatory cytokines (IL‐6, INF‐γ, IL‐1β, and TNF‐α) and the mediators of vitamin D (Ca, iPTH, and phosphorus); however, the anti‐inflammatory cytokine, IL‐10 correlated positively with the mediators of vitamin D.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2050-4527
2050-4527
DOI:10.1002/iid3.676