Search Results - "Buckley, Mark G"

Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release by He, Shaoheng, Aslam, Akhmed, Gaça, Marianna D A, He, Yongsong, Buckley, Mark G, Hollenberg, Morley D, Walls, Andrew F

“…Tryptase, the major secretory product of human mast cells, is emerging as a new target for therapeutic intervention in allergic airways disease. We have…”
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The release of basogranulin in response to IgE-dependent and IgE-independent stimuli: Validity of basogranulin measurement as an indicator of basophil activation by Mochizuki, Akinori, McEuen, Alan R., Buckley, Mark G., Walls, Andrew F.

“…Background: Basogranulin, the novel basophil granule protein recognized by the monoclonal antibody BB1, can be released by stimulation with anti-IgE antibody…”
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Mass, charge, and subcellular localization of a unique secretory product identified by the basophil-specific antibody BB1 by MCEUEN, Alan R, CALAFAT, Jero, COMPTON, Steven J, EASOM, Nicholas J. W, BUCKLEY, Mark G, KNOL, Edward F, WALLS, Andrew F

“…BB1 is a basophil-specific mAb (Lab Invest 1999;79:27-38). The identity of the corresponding antigen has not been determined, but it gives a granular…”
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CCR3-Blocking Antibody Inhibits Allergen-Induced Eosinophil Recruitment in Human Skin Xenografts from Allergic Patients by Sénéchal, Stéphanie, Fahy, Olivier, Gentina, Thibaut, Vorng, Han, Capron, Monique, Walls, Andrew F, McEuen, Alan R, Buckley, Mark G, Hamid, Qutayba, Wallaert, Benoît, Tonnel, André Bernard, Tsicopoulos, Anne

“…Eosinophil, basophil, and T helper 2 (TH2) cell recruitment into tissues is a characteristic feature of allergic diseases. These cells have in common the…”
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C-C Chemokines in Allergen-Induced Late-Phase Cutaneous Responses in Atopic Subjects: Association of Eotaxin with Early 6-Hour Eosinophils, and of Eotaxin-2 and Monocyte Chemoattractant Protein-4 with the Later 24-Hour Tissue Eosinophilia, and Relationship to Basophils and Other C-C Chemokines (Monocyte Chemoattractant Protein-3 and RANTES) by Ying, Sun, Robinson, Douglas S, Meng, Qiu, Barata, Luis T, McEuen, Alan R, Buckley, Mark G, Walls, Andrew F, Askenase, Philip W, Kay, A. Barry

“…The relationship of expression of the C-C chemokines eotaxin, eotaxin 2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4 to the kinetics of…”
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Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohnʼs disease patients treated with infliximab by Sabatino, Antonio Di, Saarialho-Kere, Ulpu, Buckley, Mark G, Gordon, John N, Biancheri, Paolo, Rovedatti, Laura, Corazza, Gino R, MacDonald, Thomas T, Pender, Sylvia L.F

“…BACKGROUND AND AIMSThe mechanism by which anti-tumor necrosis factor (TNF)-α therapy promotes rapid closure of fistulas and mucosal wound healing in Crohnʼs…”
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Basophils, eosinophils, and mast cells in atopic and nonatopic asthma and in late-phase allergic reactions in the lung and skin by Macfarlane, Alison J., Kon, Onn M., Smith, Susan J., Zeibecoglou, Kyriaki, Khan, L.Nasreen, Barata, Luis T., McEuen, Alan R., Buckley, Mark G., Walls, Andrew F., Meng, Qiu, Humbert, Marc, Barnes, Neil C., Robinson, Douglas S., Ying, Sun, Kay, A.Barry

“…Background: Previous studies used indirect methods to identify basophils in the bronchi in asthma, and the numbers were not compared with eosinophils and mast…”
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The inhibition of mast cell activation by neutrophil lactoferrin: uptake by mast cells and interaction with tryptase, chymase and cathepsin G by He, Shaoheng, McEuen, Alan R, Blewett, Sally A, Li, Ping, Buckley, Mark G, Leufkens, Paul, Walls, Andrew F

“…Inhibitors of mast cell tryptase and chymase can be effective as mast cell stabilising compounds. Lactoferrin has been reported to inhibit tryptase activity,…”
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Basophil and eosinophil accumulation and mast cell degranulation in the nasal mucosa of patients with hay fever after local allergen provocation by KleinJan, Alex, McEuen, Alan R., Dijkstra, Mariska D., Buckley, Mark G., Walls, Andrew F., Fokkens, Wytske J.

“…Background: Basophils and mast cells have certain similarities and are believed to be important in upper and lower respiratory allergy. Objective: We sought to…”
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Chemokine-Induced Cutaneous Inflammatory Cell Infiltration in a Model of Hu-PBMC-SCID Mice Grafted with Human Skin by Fahy, Olivier, Porte, Henri, Sénéchal, Stéphanie, Vorng, Han, McEuen, Alan R., Buckley, Mark G., Walls, Andrew F., Wallaert, Benoît, Tonnel, André-Bernard, Tsicopoulos, Anne

“…Recently, certain chemokines and chemokine receptors have been preferentially associated with the selective recruitment in vitro of type 1 T cells, such as…”
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Number, fixation properties, dye-binding and protease expression of duodenal mast cells: comparisons between healthy subjects and patients with gastritis or Crohn's disease by Beil, W J, Schulz, M, McEuen, A R, Buckley, M G, Walls, A F

“…There is an accumulation of evidence to suggest that mast cells may play a key role in gastrointestinal inflammation. We have investigated the numbers and…”
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Two distinct forms of human mast cell chymase by McEuen, Alan R., Gaça, Marianna D. A., Buckley, Mark G., He, Shaoheng, Gore, Michael G., Walls, Andrew F.

“…Chymase, a chymotrypsin‐like protease secreted by human mast cells, is generally considered to be a single enzyme. However, by heparin‐agarose chromatography…”
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Development and characterization of a monoclonal antibody specific for human basophils and the identification of a unique secretory product of basophil activation by McEuen, A R, Buckley, M G, Compton, S J, Walls, A F

“…Despite increasing evidence that basophils can infiltrate into inflamed tissues during allergic reactions, determination of the extent of infiltration and…”
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Mast cell subpopulations in the synovial tissue of patients with osteoarthritis: selective increase in numbers of tryptase-positive, chymase-negative mast cells by Buckley, Mark G., Gallagher, Patrick J., Walls, Andrew F.

“…Although there is relatively little evidence of inflammation in osteoarthritis (OA), increases in mast cell numbers and mast cell activation are prominent…”
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The detection of mast cell subpopulations in formalin-fixed human tissues using a new monoclonal antibody specific for chymase by Buckley, Mark G., McEuen, Alan R., Walls, Andrew F.

“…Chymase is an important marker for human mast cells as well as a mediator of inflammation and matrix remodelling, but research into chymase‐containing mast…”
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Allergen-induced upregulation of protease activated receptor 2 (PAR-2) expression in the bronchial epithelium of asthmatics by Aslam, Akhmed, Buckley, Mark G, Compton, Steven J, Wilson, Susan J, Howarth, Peter H, Walls, Andrew F

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CCR3-blocking antibody inhibits allergen-induced eosinophil recruitment in human skin xenografts from allergic patients by Fahy, Olivier, Senechal, Stephanie, Lassalle, Philippe, Vorng, Han, Capron, Monique, Walls, Andrew F, McEuen, Alan R, Buckley, Mark G, Hamid, Qutayba A, Wallaert, Benoit, Tonnel, Andre Bernard, Tiscopoulos, Anne AP

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Granulocyte recruitment by human mast cell tryptase by Walls, A F, He, S, Teran, L M, Buckley, M G, Jung, K S, Holgate, S T, Shute, J K, Cairns, J A

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Interferon-gamma inhibits serotonin release from mouse peritoneal mast cells by Coleman, J W, Buckley, M G, Holliday, M R, Morris, A G

“…Conditioned medium (CM) from concanavalin A-activated mouse spleen cells inhibits antigen-induced 5-hydroxytryptamine (5-HT) release from mouse peritoneal mast…”
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Cycloheximide treatment of mouse mast cells inhibits serotonin release. Evidence of a requirement for newly synthesized protein in the exocytotic response by Buckley, M G, Coleman, J W

“…Treatment of mouse peritoneal mast cells and mouse bone marrow-derived cloned mast cells with the protein synthesis inhibitor cycloheximide led to a marked…”
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