Search Results - "Buckler, K. J."

The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells by Wyatt, C. N., Buckler, K. J.

“…Inhibitors of mitochondrial energy metabolism have long been known to be potent stimulants of the carotid body, yet their mechanism of action remains obscure…”
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A novel oxygen-sensitive potassium current in rat carotid body type I cells by Buckler, K J

“…1. Hypoxic stimuli depolarize carotid body type I cells causing voltage-gated calcium influx. This study investigates the cause of this membrane…”
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The lipid-activated two-pore domain K+ channel TREK-1 is resistant to hypoxia: implication for ischaemic neuroprotection by Buckler, K. J., Honoré, E.

“…TREK-1 is a member of the two-pore domain potassium (K 2P ) channel family that is mechano-, heat, pH, voltage and lipid sensitive. It is highly expressed in…”
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Effects of mitochondrial uncouplers on intracellular calcium, pH and membrane potential in rat carotid body type I cells by Buckler, K. J., Vaughan‐Jones, R. D.

“…Mitochondrial uncouplers are potent stimulants of the carotid body. We have therefore investigated their effects upon isolated type I cells. Both…”
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Differential effects of halothane and sevoflurane on hypoxia-induced intracellular calcium transients of neonatal rat carotid body type I cells by Pandit, J. J., Buckler, K. J.

“…Background The purpose of this study was to investigate the effects of halothane and sevoflurane on the magnitude of the increase in intracellular calcium with…”
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Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells by Buckler, K J, Vaughan‐Jones, R D

“…1. We have studied the effects of hypoxia on membrane potential and [Ca2+]i in enzymically isolated type I cells of the neonatal rat carotid body (the…”
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Altered Ca2+ handling in ventricular myocytes isolated from diabetic rats by Lagadic-Gossmann, D, Buckler, K J, Le Prigent, K, Feuvray, D

“…It has been suggested that alterations in intracellular Ca2+ homeostasis may be responsible for the development of diabetic cardiomyopathy. We have studied the…”
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Role of bicarbonate in pH recovery from intracellular acidosis in the guinea-pig ventricular myocyte by Lagadic‐Gossmann, D, Buckler, K J, Vaughan‐Jones, R D

“…1. Intracellular pH (pHi) was recorded ratiometrically in isolated guinea-pig ventricular myocytes using the pH-sensitive fluoroprobe, carboxy-SNARF-1…”
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Effects of hypercapnia on membrane potential and intracellular calcium in rat carotid body type I cells by Buckler, K J, Vaughan-Jones, R D

“…1. An acid-induced rise in the intracellular calcium concentration ([Ca2+]i) of type I cells is thought to play a vital role in pH/PCO2 chemoreception by the…”
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Application of a new pH-sensitive fluoroprobe (carboxy-SNARF-1) for intracellular pH measurement in small, isolated cells by BUCKLER, K. J, VAUGHAN-JONES, R. D

“…We report the use of a new pH-sensitive dual-emission fluoroprobe, carboxy-seminaphthorhodafluor-1 (carboxy-SNARF-1) for ratiometric recording of intracellular…”
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Transduction of chemostimuli by the type I carotid body cell by Peers, C, Buckler, K J

“…The postulated mechanisms for hypoxic and acidic chemotransduction by type I cells that we have described here are summarized in the diagrams of Fig. 4. Most…”
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Intracellular pH and its regulation in isolated type I carotid body cells of the neonatal rat by Buckler, K J, Vaughan‐Jones, R D, Peers, C, Nye, P C

“…1. The dual-emission pH-sensitive fluoroprobe carboxy-SNARF-1 (carboxy-seminaptharhodofluor) was used to measure pHi in type I cells enzymically dispersed from…”
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Effects of extracellular pH, PCO2 and HCO3- on intracellular pH in isolated type-I cells of the neonatal rat carotid body by Buckler, K J, Vaughan‐Jones, R D, Peers, C, Lagadic‐Gossmann, D, Nye, P C

“…1. The effects of changing PCO2 extracellular pH (pHo) and HCO3- on intracellular pH (pHi) were studied in isolated neonatal rat type-I carotid body cells…”
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Muscarinic and nicotinic receptors raise intracellular Ca2+ levels in rat carotid body type I cells by Dasso, L L, Buckler, K J, Vaughan-Jones, R D

“…1. The effects of cholinergic agonists upon intracellular free Ca2+ levels ([Ca2+]i) have been studied in enzymically isolated rat carotid body single type I…”
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An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells by Buckler, Keith J., Williams, Beatrice A., Honore, Eric

“…The biophysical and pharmacological properties of an oxygen-sensitive background K + current in rat carotid body type-I cells were investigated and compared…”
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Effects of acidic stimuli on intracellular calcium in isolated type I cells of the neonatal rat carotid body by BUCKLER, K. J, VAUGHAN-JONES, R. D

“…We have investigated the effects of acidic stimuli upon [Ca2+]i in isolated carotid body type I cells from the neonatal rat using indo-1 (AM-loaded). Under…”
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Identification of an oxygen-sensitive potassium channel in neonatal rat carotid body type I cells by Williams, B A, Buckler, K J

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Adrenaline and extracellular ATP switch between two modes of acid extrusion in the guinea-pig ventricular myocyte by D Lagadic-Gossmann, R D Vaughan-Jones, K J Buckler

“…1. Intracellular pH (pHi) was recorded in isolated guinea-pig ventricular myocytes using the pH-sensitive fluoroprobe, carboxy-SNARF-1…”
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Role of potassium channels in hypoxic chemoreception in rat carotid body type-I cells by Buckler, K J

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A dual acid-influx transport system in the carotid body type I cell. Acid influx in carotid body type I cells by Tsai, K L, Vaughan-Jones, R D, Buckler, K J

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