Search Results - "Buckheit, R W"

Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-targeted inhibition of human immunodeficiency virus by Hartman, T.L., Yang, L., Helfrick, A.N., Hassink, M., Shank, N.I., George Rosenker, K., Scerba, M.T., Saha, M., Hughes, E., Wang, A.Q., Xu, X., Gupta, P., Buckheit, R.W., Appella, D.H.

“…Although the effective use of highly active antiretroviral therapy results in the suppression of virus production in infected individuals, it does not…”
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Synthesis and Biological Activity of Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2-Aryl-Substituted Benzimidazoles by Roth, Thomas, Morningstar, Marshall L, Boyer, Paul L, Hughes, Stephen H, Buckheit, Robert W, Michejda, Christopher J

“…The development of new nonnucleoside inhibitors of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) active against the drug-induced…”
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Vaginal film for prevention of HIV: using visual and tactile evaluations among potential users to inform product design by Guthrie, K M, Rohan, L, Rosen, R K, Vargas, S E, Shaw, J G, Katz, D, Kojic, E M, Ham, A S, Friend, D, Buckheit, K W, Buckheit, Jr, R W

“…Topical prevention of HIV and other STIs is a global health priority. To provide options for users, developers have worked to design safe, effective and…”
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Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development by BOYD, M. R, GUSTAFSON, K. R, CURRENS, M. J, CARDELLINA, J. H, BUCKHEIT, R. W, NARA, P. L, PANNELL, L. K, SOWDER, R. C, HENDERSON, L. E, MCMAHON, J. B, SHOEMAKER, R. H, O'KEEFE, B. R, MORI, T, GULAKOWSKI, R. J, WU, L, RIVERA, M. I, LAURENCOT, C. M

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Combinatorially Selected Guanosine-Quartet Structure is a Potent Inhibitor of Human Immunodeficiency Virus Envelope-Mediated Cell Fusion by Wyatt, Jacqueline R., Vickers, Timothy A., Roberson, Joseph L., Buckheit, Robert W., Klimkait, Thomas, DeBaets, Elizabeth, Davis, Peter W., Rayner, Bernard, Imbach, J. L., Ecker, David J.

“…The phosphorothioate oligonucleotide T2G4T2was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate…”
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The calanolides, a novel HIV-inhibitory class of Coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum by KASHMAN, Y, GUSTAFSON, K. R, FULLER, R. W, CARDELLINA, J. H, MCMAHON, J. B, CURRENS, M. J, BUCKHEIT, R. W, HUGHES, S. H, CRAGG, G. M, BOYD, M. R

“…Eight new coumarin compounds (1-8) were isolated by anti-HIV bioassay-guided fractionation of an extract of Calophyllum lanigerum. The structures of calanolide…”
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Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS by Rice, William G., Supko, Jeffrey G., Malspeis, Louis, Buckheit, Robert W., Clanton, David, Bu, Ming, Graham, Lisa, Schaeffer, Catherine A., Turpin, Jim A., Domagala, John, Gogliotti, Rocco, Bader, John P., Halliday, Susan M., Coren, Lori, Sowder, Raymond C., Arthur, Larry O., Henderson, Louis E.

“…Strategies for the treatment of human immunodeficiency virus-type 1 (HIV-1) infection must contend with the obstacle of drug resistance. HIV-1 nucleocapsid…”
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Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms by MCMAHON, J. B, CURRENS, M. J, GULAKOWSKI, R. J, BUCKHEIT, R. W, LACKMAN-SMITH, C, HALLOCK, Y. F, BOYD, M. R

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Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins by RICE, W. G, BAKER, D. C, FIELD, L, SINGH, P. K, TURPIN, A. J. A, SCHAEFFER, C. A, GRAHAM, L, BU, M, TERPENING, S, CLANTON, D, SCHULTZ, R, BADER, J. P, BUCKHEIT, R. W

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Inhibition of in Vitro and in Vivo HIV Replication by a Distamycin Analogue That Interferes with Chemokine Receptor Function:  A Candidate for Chemotherapeutic and Microbicidal Application by Howard, O. M. Z, Oppenheim, J. J, Hollingshead, Melinda G, Covey, Joseph M, Bigelow, J, McCormack, J. J, Buckheit, Robert W, Clanton, David J, Turpin, Jim A, Rice, William G

“…Select chemokine receptors act as coreceptors for HIV-1 entry into human cells and represent targets for antiviral therapy. In this report we describe a…”
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Anti-HIV michellamines from Ancistrocladus korupensis by Boyd, M R, Hallock, Y F, Cardellina, 2nd, J H, Manfredi, K P, Blunt, J W, McMahon, J B, Buckheit, Jr, R W, Bringmann, G, Schäffer, M, Cragg, G M

“…Here we report details of the isolation and determination of the absolute configurations and comparative anti-HIV activities of novel, atropisomeric…”
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Diarylsulfones, a new chemical class of nonnucleoside antiviral inhibitors of human immunodeficiency virus type 1 reverse transcriptase by MCMAHON, J. B, GULAKOWSKI, R. J, WHITE, E. L, BADER, J. P, BOYD, M. R, WEISLOW, O. S, SCHULTZ, R. J, NARAYANAN, V. L, CLANTON, D. J, PEDEMONTE, R, WASSMUNDT, F. W, BUCKHEIT, R. W, DECKER, W. D

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Unique Anti-Human Immunodeficiency Virus Activities of the Nonnucleoside Reverse Transcriptase Inhibitors Calanolide A, Costatolide, and Dihydrocostatolide by BUCKHEIT, R. W, WHITE, E. L, FLIAKAS-BOLTZ, V, RUSSELL, J, STUP, T. L, KINJERSKI, T. L, OSTERLING, M. C, WEIGAND, A, BADER, J. P

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T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1 by Ojwang, J O, Buckheit, R W, Pommier, Y, Mazumder, A, De Vreese, K, Esté, J A, Reymen, D, Pallansch, L A, Lackman-Smith, C, Wallace, T L

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Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide by BUCKHEIT, R. W, KINJERSKI, T. L, BADER, J. P, YANG, S. S, FLIAKAS-BOLTZ, V, RUSSELL, J. D, STUP, T. L, PALLANSCH, L. A, BROUWER, W. G, DAO, D. C, HARRISON, W. A, SCHULTZ, R. J

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Structural Analogues of the Calanolide Anti-HIV Agents. Modification of the trans-10,11-Dimethyldihydropyran-12-ol Ring (Ring C) by Zembower, David E, Liao, Shuyuan, Flavin, Michael T, Xu, Ze-Qi, Stup, Tracy L, Buckheit, Robert W, Khilevich, Albert, Mar, Aye Aye, Sheinkman, Abram K

“…(+)-Calanolide A is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1), which was isolated from an extract of…”
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The Biological Effects of Structural Variation at the Meta Position of the Aromatic Rings and at the End of the Alkenyl Chain in the Alkenyldiarylmethane Series of Non-Nucleoside Reverse Transcriptase Inhibitors by Xu, Guozhang, Micklatcher, Mark, Silvestri, Maximilian A, Hartman, Tracy L, Burrier, Jennifer, Osterling, Mark C, Wargo, Heather, Turpin, Jim A, Buckheit, Robert W, Cushman, Mark

“…In an effort to elucidate a set of structure−activity relationships in the alkenyldiarylmethane (ADAM) series of non-nucleoside reverse transcriptase…”
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Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus type-1 by Currens, M J, Gulakowski, R J, Mariner, J M, Moran, R A, Buckheit, Jr, R W, Gustafson, K R, McMahon, J B, Boyd, M R

“…Calanolide A, recently discovered in extracts from the tropical rainforest tree, Calophyllum lanigerum, is a novel inhibitor of the human immunodeficiency…”
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Evaluation of Selected Chemotypes in Coupled Cellular and Molecular Target-Based Screens Identifies Novel HIV-1 Zinc Finger Inhibitors by Rice, William G, Turpin, Jim A, Schaeffer, Catherine A, Graham, Lisa, Clanton, David, Buckheit, Robert W, Zaharevitz, Daniel, Summers, Michael F, Wallqvist, Anders, Covell, David G

“…Conservation of the Cys-Xaa2-Cys-Xaa4-His-Xaa4-Cys retroviral zinc finger sequences and their absolute requirement in both the early and late phases of…”
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Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs by W B Parker, E L White, S C Shaddix, L J Ross, R W Buckheit, Jr, J M Germany, J A Secrist, 3rd, R Vince, W M Shannon

“…Carbovir (the carbocyclic analog of 2'-3'-didehydro-2',3'-dideoxyguanosine) is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication…”
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