Search Results - "Buckalew, Angela R"

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition by Wang, Jun, Hallinger, Daniel R., Murr, Ashley S., Buckalew, Angela R., Lougee, Ryan R., Richard, Ann M., Laws, Susan C., Stoker, Tammy E.

“…In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening…”
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Understanding the effects of atrazine on steroidogenesis in rat granulosa and H295R adrenal cortical carcinoma cells by Tinfo, Nicole S., Hotchkiss, Michelle G., Buckalew, Angela R., Zorrilla, Leah M., Cooper, Ralph L., Laws, Susan C.

“…Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) was introduced in the 1950s as a broad spectrum herbicide, and remains one of the most widely used…”
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High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter by Stoker, Tammy E., Wang, Jun, Murr, Ashley S., Bailey, Jarod R., Buckalew, Angela R.

“…Over the past decade, there has been increased concern for environmental chemicals that can target various sites within the hypothalamic–pituitary–thyroid axis…”
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High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library by Wang, Jun, Hallinger, Daniel R, Murr, Ashley S, Buckalew, Angela R, Simmons, Steven O, Laws, Susan C, Stoker, Tammy E

“…Thyroid uptake of iodide via the sodium-iodide symporter (NIS) is the first step in the biosynthesis of thyroid hormones that are critical for health and…”
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Evaluation of potential sodium-iodide symporter (NIS) inhibitors using a secondary Fischer rat thyroid follicular cell (FRTL-5) radioactive iodide uptake (RAIU) assay by Buckalew, Angela R., Wang, Jun, Murr, Ashley S., Deisenroth, Chad, Stewart, Wendy M., Stoker, Tammy E., Laws, Susan C.

“…The Fischer rat thyroid follicular cell line (FRTL-5) endogenously expresses the sodium-iodide symporter (NIS) and has been used to identify environmental…”
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Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS) by Hallinger, Daniel R., Murr, Ashley S., Buckalew, Angela R., Simmons, Steven O., Stoker, Tammy E., Laws, Susan C.

“…The U.S. EPA's Endocrine Disruptor Screening Program aims to use high-throughput assays and computational toxicology models to screen and prioritize chemicals…”
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Expanded high-throughput screening and chemotype-enrichment analysis of the phase II: e1k ToxCast library for human sodium-iodide symporter (NIS) inhibition by Wang, Jun, Richard, Ann M., Murr, Ashley S., Buckalew, Angela R., Lougee, Ryan R., Shobair, Mahmoud, Hallinger, Daniel R., Laws, Susan C., Stoker, Tammy E.

“…The sodium-iodide symporter (NIS) mediates the uptake of iodide into the thyroid. Inhibition of NIS function by xenobiotics has been demonstrated to suppress…”
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In vitro and in vivo effects of 5-aminotetrazole (5-AT), an energetic compound by Adams, Valerie H., Bazar, Matthew A., Reinke, Emily N., Buckalew, Angela R., Eck, William S.

“…Perchlorate is an important oxidizer used in propellants, pyrotechnics, and as a gas generator in commercial airbags, fireworks, and roadside flares. It is…”
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Adrenocorticotropin (ACTH) and corticosterone secretion by perifused pituitary and adrenal glands from rodents exposed to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) by Pitt, Jeff A., Buckalew, Angela R., House, Denis E., Abbott, Barbara D.

“…Although in utero maternal stress has been shown to have lasting effects on rodent offspring, fetal effects of chemically-induced alterations of the maternal…”
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Methoxychlor-induced alterations in the histological expression of angiogenic factors in pituitary and uterus by Goldman, Jerome M, Murr, Ashley S, Buckalew, Angela R, Schmid, Judith E, Abbott, Barbara D

“…Within the reproductive system, oestrogenic stimulation of uterine and pituitary tissue typically causes a proliferative response accompanied by an angiogenic…”
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Suppression of the Steroid-Primed Luteinizing Hormone Surge in the Female Rat by Sodium Dimethyldithiocarbamate: Relationship to Hypothalamic Catecholamines and GnRH Neuronal Activation by Goldman, Jerome M., Murr, Ashley S., Buckalew, Angela R., Cooper, Ralph L.

“…In female rodents, hypothalamic norepinephrine (NE) has a role in stimulating the secretion of gonadotropin-releasing hormone (GnRH) that triggers the…”
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EGF and TGF-α Expression Influence the Developmental Toxicity of TCDD: Dose Response and AhR Phenotype in EGF, TGF-α, and EGF + TGF-α Knockout Mice by Abbott, Barbara D., Buckalew, Angela R., DeVito, Michael J., Ross, David, Bryant, P. Lamont, Schmid, Judith E.

“…The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces cleft palate (CP) and hydronephrosis (HN) in mice. The etiology of these defects…”
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AN IN VITRO MODEL FOR MURINE URETERIC EPITHELIAL CELLS by Bryant, P. LaMont, Reid, Lola M, Diala, Edward S, Abbott, Barbara D, Buckalew, Angela R

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Effects of epidermal growth factor (EGF), transforming growth factor-α (TGFα), and 2,3,7,8-tetrachlorodibenzo-p-dioxin on fusion of embryonic palates in serum-free organ culture using wild-type, EGF knockout, and TGFα knockout mouse strains by Abbott, Barbara D., Buckalew, Angela R., Leffler, Korin E.

“…BACKGROUND 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) is teratogenic in mice, producing cleft palate (CP). TCDD exposure disrupts expression of epidermal…”
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Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-α by BRYANT, P. Lamont, SCHMID, Judith E, FENTON, Suzanne E, BUCKALEW, Angela R, ABBOTT, Barbara D

“…2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure produces hydronephrosis and cleft palate in mice. These responses are correlated with disruption of…”
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Moderating influence of the drinking water disinfection by-product dibromoacetic acid on a dithiocarbamate-induced suppression of the luteinizing hormone surge in female rats by Goldman, Jerome M., Murr, Ashley S., Buckalew, Angela R., Ferrell, Janet M., Cooper, Ralph L.

“…The disinfection by-product dibromoacetic acid (DBA) has been found in female rats to increase circulating concentrations of both estradiol (E2) and estrone…”
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Peripubertal exposure to oxyfluorfen, a diphenyl herbicide, delays pubertal development in the male rat by antagonizing androgen receptor activity by Murr, Ashley S, Buckalew, Angela R, Devane, Grace, Bailey, Jarod R, Ford, Jermaine L, Gray, Leon Earl, Stoker, Tammy E

“…Abstract We recently identified the herbicide oxyfluorfen as an inhibitor of iodide uptake by the sodium iodide symporter, a key step in thyroid hormone…”
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Effects of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) on fetal mouse urinary tract epithelium in vitro by Bryant, P.LaMont, Reid, Lola M., Schmid, Judith E., Buckalew, Angela R., Abbott, Barbara D.

“…2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), produces hydronephrosis by altering the differentiation and proliferation of ureteric epithelial cells in the…”
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Adverse Reproductive Outcomes in the Transgenic Ah Receptor-Deficient Mouse by Abbott, Barbara D., Schmid, Judith E., Pitt, Jeff A., Buckalew, Angela R., Wood, Carmen R., Held, Gary A., Diliberto, Janet J.

“…The aryl hydrocarbon receptor (AHR) is a transcriptional regulatory protein that binds to upstream DNA response elements of target genes. Activation of the AHR…”
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Placental defects in ARNT‐knockout conceptus correlate with localized decreases in VEGF‐R2, Ang‐1, and Tie‐2 by Abbott, Barbara D., Buckalew, Angela R.

“…The aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcriptional regulator that heterodimerizes with Per‐ARNT‐Sim (PAS) proteins. ARNT also…”
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