Search Results - "Buck, Wayne R."

Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies by Rao, Mohan S, Van Vleet, Terry R, Ciurlionis, Rita, Buck, Wayne R, Mittelstadt, Scott W, Blomme, Eric A G, Liguori, Michael J

“…Gene expression profiling is a useful tool to predict and interrogate mechanisms of toxicity. RNA-Seq technology has emerged as an attractive alternative to…”
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Identification of VEGF Signaling Inhibition-Induced Glomerular Injury in Rats through Site-Specific Urinary Biomarkers by Yang, Yi, Kowalkowski, Kenneth, Ciurlionis, Rita, Buck, Wayne R, Glaser, Keith B, Albert, Daniel H, Blomme, Eric A G

“…Cancer therapies targeting the vascular endothelial growth factor (VEGF) signaling pathway can lead to renal damage by disrupting the glomerular…”
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Evaluation of Quantitative Platforms for Single Target Mass Spectrometry Imaging by Bowman, Andrew P, Sawicki, James, Talaty, Nari N, Buck, Wayne R, Yang, Junhai, Wagner, David S

“…(1) Imaging of pharmaceutical compounds in tissue is an increasingly important subsection of Mass Spectrometry Imaging (MSI). Identifying proper target…”
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In-vitro modeling of intravenous drug precipitation by the optical spatial precipitation analyzer (OSPREY) by Radosevich, Andrew J., Martin, Ruth L., Buck, Wayne R., Hicks, Lauren, Wilsey, Amanda, Pan, Jeffrey Y.

“…[Display omitted] •Prospective small molecule drugs can precipitate when injected into blood at elevated concentrations for toxicology studies.•Improved…”
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Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion by Jacobson, Peer B., Mothe, Andrea, Levy, Aharon, Krakovsky, Michael, Hooker, Bradley A., Zhang, Xiaomeng, Mollon, Jennifer, Mordashova, Yulia, Droescher, Mathias, Weiss, Sabine, Barghorn, Stefan, Dreher, Ingeborg, Awwad, Khader, Nimmrich, Volker, Huang, Lili, Fung, Emma, Buck, Wayne R., Pfleeger, Kimberly, Ziemann, Adam, Smith, Elaine, Fox, Gerard B., Tator, Charles H., Gold, Michael

“…Repulsive guidance molecule A (RGMa) is an inhibitor of neuronal growth and survival which is upregulated in the damaged central nervous system following acute…”
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Small RNA Sequencing to Discover Circulating MicroRNA Biomarkers of Testicular Toxicity in Dogs by Shing, Jennifer C., Schaefer, Kai, Grosskurth, Shaun E., Vo, Andy H., Sharapova, Tatiana, Bodié, Karen, Kambara, Takahito, Buck, Wayne R.

“…Predictive indicators of testicular toxicity could improve drug development by allowing early in-life screening for this adverse effect before it becomes…”
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Biomarker evaluation of skeletal muscle toxicity following clofibrate administration in rats by Bodié, Karen, Buck, Wayne R., Pieh, Julia, Liguori, Michael J., Popp, Andreas

“…The use of sensitive biomarkers to monitor skeletal muscle toxicity in preclinical toxicity studies is important for the risk assessment in humans during the…”
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BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors by Judd, Andrew S, Bawa, Bhupinder, Buck, Wayne R, Tao, Zhi-Fu, Li, Yingchun, Mitten, Michael J, Bruncko, Milan, Catron, Nathaniel, Doherty, George, Durbin, Kenneth R, Enright, Brian, Frey, Robin, Haasch, Deanna, Haman, Sandra, Haight, Anthony R, Henriques, Tracy A, Holms, James, Izeradjene, Kamel, Judge, Russell A, Jenkins, Gary J, Kunzer, Aaron, Leverson, Joel D, Martin, Ruth L, Mitra, Diya, Mittelstadt, Scott, Nelson, Lorne, Nimmer, Paul, Palma, Joann, Peterson, Richard, Phillips, Darren C, Ralston, Sherry L, Rosenberg, Saul H, Shen, Xiaoqiang, Song, Xiaohong, Vaidya, Kedar R, Wang, Xilu, Wang, Jin, Xiao, Yu, Zhang, Haichao, Zhang, Xinxin, Blomme, Eric A, Boghaert, Erwin R, Kalvass, John C, Phillips, Andrew, Souers, Andrew J

“…Overexpression of the antiapoptotic protein B-cell lymphoma-extra large (BCL-XL) is associated with drug resistance and disease progression in numerous…”
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BCL-X L -targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors by Judd, Andrew S, Bawa, Bhupinder, Buck, Wayne R, Tao, Zhi-Fu, Li, Yingchun, Mitten, Michael J, Bruncko, Milan, Catron, Nathaniel, Doherty, George, Durbin, Kenneth R, Enright, Brian, Frey, Robin, Haasch, Deanna, Haman, Sandra, Haight, Anthony R, Henriques, Tracy A, Holms, James, Izeradjene, Kamel, Judge, Russell A, Jenkins, Gary J, Kunzer, Aaron, Leverson, Joel D, Martin, Ruth L, Mitra, Diya, Mittelstadt, Scott, Nelson, Lorne, Nimmer, Paul, Palma, Joann, Peterson, Richard, Phillips, Darren C, Ralston, Sherry L, Rosenberg, Saul H, Shen, Xiaoqiang, Song, Xiaohong, Vaidya, Kedar R, Wang, Xilu, Wang, Jin, Xiao, Yu, Zhang, Haichao, Zhang, Xinxin, Blomme, Eric A, Boghaert, Erwin R, Kalvass, John C, Phillips, Andrew, Souers, Andrew J

“…Overexpression of the antiapoptotic protein B-cell lymphoma-extra large (BCL-X ) is associated with drug resistance and disease progression in numerous…”
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Lentivirus-Specific Cytotoxic T-Lymphocyte Responses Are Rapidly Lost in Thymectomized Cats Infected with Feline Immunodeficiency Virus by HAYES, Kathleen A, KÖKSOY, Sadi, PHIPPS, Andrew J, BUCK, Wayne R, KOCIBA, Gary J, MATHES, Lawrence E

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Immunomodulatory effects of tick saliva on dermal cells exposed to Borrelia burgdorferi, the agent of Lyme disease by Scholl, Dorothy C, Embers, Monica E, Caskey, John R, Kaushal, Deepak, Mather, Thomas N, Buck, Wayne R, Morici, Lisa A, Philipp, Mario T

“…The prolonged feeding process of ixodid ticks, in combination with bacterial transmission, should lead to a robust inflammatory response at the blood-feeding…”
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Cross-laboratory analytical validation of the cardiac biomarker NT-proANP in rat by Vinken, Petra, Reagan, William J., Rodriguez, Luis A., Buck, Wayne R., Lai-Zhang, Jie, Goeminne, Nick, Barbacci, Gaby, Liu, Ray, King, Nicholas M.P., Engle, Steven K., Colton, Heidi

“…Natriuretic peptides, including N-terminal-proatrial natriuretic peptide (NT-proANP) are cardiac hormones that are produced in response to myocardial stretch…”
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Selective Extraction and Effective Separation of Galactosylsphingosine (Psychosine) and Glucosylsphingosine from Other Glycosphingolipids in Pathological Tissue Samples by Li, Yu-Teh, Li, Su-Chen, Buck, Wayne R., Haskins, Mark E., Wu, Sz-Wei, Khoo, Kay-Hooi, Sidransky, Ellen, Bunnell, Bruce A.

“…To facilitate the study of the chemical pathology of galactosylsphingosine (psychosine, GalSph) in Krabbe disease and glucosylsphingosine (GlcSph) in Gaucher…”
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The rapidly evolving field of biomarkers of cardiac function and injury in dogs: Challenges and next steps by Buck, Wayne R., LeRoy, Bruce E., Blomme, Eric A.G.

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Comparing levels of biochemical markers in CSF from cannulated and non-cannulated rats by Cassar, Steven C., Tovcimak, Ann E., Rustay, Nathan R., Ellis, Teresa A., Hooker, Bradley A., Witte, David G., Li, Jinhe, Buck, Wayne R., Scharf, Dancia, Muller, Uwe, Jeromin, Andreas, Wang, Kevin K.W., Waring, Jeffrey F.

“…▶ Cerebrospinal fluid (CSF) was withdrawn from 71 intracisternally cannulated and 73 non-cannulated rats. ▶ CSF was analyzed for concentrations of 3…”
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Use of traditional end points and gene dysregulation to understand mechanisms of toxicity: toxicogenomics in mechanistic toxicology by Buck, Wayne R, Waring, Jeffrey F, Blomme, Eric A

“…Microarray technologies can be used to generate massive amounts of gene expression information as an initial step to decipher the molecular mechanisms of…”
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Purification of drugs from biological fluids by counter-current chromatography by Hochlowski, Jill E., Pan, Jeffrey Y., Searle, Philip A., Buck, Wayne R., Spanton, Stephen G.

“…Experiments were performed to demonstrate the potential of counter-current chromatography (CCC) for the isolation of drugs and their metabolites from…”
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Enrichment with Wood Blocks Does Not Affect Toxicity Assessment in an Exploratory Toxicology Model Using Sprague-Dawley Rats by Ditewig, Amy C, Bratcher, Natalie A, Davila, Donna R, Dayton, Brian D, Ebert, Paige, Lesuisse, Philippe, Liguori, Michael J, Wetter, Jill M, Yang, Hyuna, Buck, Wayne R

“…Environmental enrichment in rodents may improve animal well-being but can affect neurologic development, immune system function, and aging. We tested the…”
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Molecular beacon genotyping for globoid cell leukodystrophy from hair roots in the twitcher mouse and rhesus macaque by Terrell, Kimberly A., Rasmussen, Terri A., Trygg, Cyndi, Bunnell, Bruce A., Buck, Wayne R.

“…Rapid and accurate genotype determination is ideal for the maintenance of breeding colonies of laboratory animal models of genetic disease. The rhesus macaque…”
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The feline model of neuroAIDS: understanding the progression towards AIDS dementia by Podell, Michael, March, Philip A., Buck, Wayne R., Mathes, Lawrence E.

“…Feline immunodeficiency virus (FIV) is a neurotropic lentivirus that produces a protracted state of immunodeficiency and encephalopathy in the cat. Recent…”
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