Search Results - "Buck, Thilo M."

Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays by Buck, Thilo M, Wijnholds, Jan

“…Inherited retinal dystrophies and optic neuropathies cause chronic disabling loss of visual function. The development of recombinant adeno-associated viral…”
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Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5 by Quinn, Peter M., Buck, Thilo M., Mulder, Aat A., Ohonin, Charlotte, Alves, C. Henrique, Vos, Rogier M., Bialecka, Monika, van Herwaarden, Tessa, van Dijk, Elon H.C., Talib, Mays, Freund, Christian, Mikkers, Harald M.M., Hoeben, Rob C., Goumans, Marie-José, Boon, Camiel J.F., Koster, Abraham J., Chuva de Sousa Lopes, Susana M., Jost, Carolina R., Wijnholds, Jan

“…Human retinal organoids from induced pluripotent stem cells (hiPSCs) can be used to confirm the localization of proteins in retinal cell types and to test…”
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Defining Phenotype, Tropism, and Retinal Gene Therapy Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats with a Spontaneous Mutation in Crb1 by Boon, Nanda, Alves, C Henrique, Mulder, Aat A, Andriessen, Charlotte A, Buck, Thilo M, Quinn, Peter M J, Vos, Rogier M, Koster, Abraham J, Jost, Carolina R, Wijnholds, Jan

“…Mutations in the Crumbs homologue 1 ( ) gene cause inherited retinal dystrophies, such as early-onset retinitis pigmentosa and Leber congenital amaurosis. A…”
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AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model by Buck, Thilo M., Vos, Rogier M., Alves, C. Henrique, Wijnholds, Jan

“…Loss of Crumbs homolog 1 (CRB1) or CRB2 proteins in Müller cells or photoreceptors in the mouse retina results in a CRB dose-dependent retinal phenotype. In…”
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AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype by Boon, Nanda, Lu, Xuefei, Andriessen, Charlotte A., Moustakas, Ioannis, Buck, Thilo M., Freund, Christian, Arendzen, Christiaan H., Böhringer, Stefan, Boon, Camiel J.F., Mei, Hailiang, Wijnholds, Jan

“…Retinitis pigmentosa and Leber congenital amaurosis are inherited retinal dystrophies that can be caused by mutations in the Crumbs homolog 1 (CRB1) gene. CRB1…”
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Sleep Deprivation Does not Change the Flash Electroretinogram in Wild-type and Opn4−/−Gnat1−/− Mice by Schoonderwoerd, Robin A., Buck, Thilo M., Andriessen, Charlotte A., Wijnholds, Jan, Hattar, Samer, Meijer, Johanna H., Deboer, Tom

“…Sleep deprivation reduces the response of neuronal activity in the suprachiasmatic nucleus (SCN) and the phase shift in circadian behaviour to phase shifting…”
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AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype by Boon, Nanda, Lu, Xuefei, Andriessen, Charlotte A., Moustakas, Ioannis, Buck, Thilo M., Freund, Christian, Arendzen, Christiaan H., Böhringer, Stefan, Boon, Camiel J.F., Mei, Hailiang, Wijnholds, Jan

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CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids by Buck, Thilo M., Quinn, Peter M.J., Pellissier, Lucie P., Mulder, Aat A., Jongejan, Aldo, Lu, Xuefei, Boon, Nanda, Koot, Daniëlle, Almushattat, Hind, Arendzen, Christiaan H., Vos, Rogier M., Bradley, Edward J., Freund, Christian, Mikkers, Harald M.M., Boon, Camiel J.F., Moerland, Perry D., Baas, Frank, Koster, Abraham J., Neefjes, Jacques, Berlin, Ilana, Jost, Carolina R., Wijnholds, Jan

“…CRB1 gene mutations can cause early- or late-onset retinitis pigmentosa, Leber congenital amaurosis, or maculopathy. Recapitulating human CRB1 phenotypes in…”
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