Search Results - "Buck, K. J."

Identifying genes for alcohol and drug sensitivity: recent progress and future directions by Crabbe, John C., Phillips, Tamara J., Buck, Kari J., Cunningham, Christopher L., Belknap, John K.

“…New methods for identifying chromosomal regions containing genes that affect murine responses to alcohol and drugs have been used to identify many provisional…”
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Harnessing the mouse to unravel the genetics of human disease by Phillips, T. J., Belknap, J. K., Hitzemann, R. J., Buck, K. J., Cunningham, C. L., Crabbe, J. C.

“…Complex traits, i.e. those with multiple genetic and environmental determinants, represent the greatest challenge for genetic analysis, largely due to the…”
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Genetic Animal Models of Alcohol and Drug Abuse by Crabbe, John C., Belknap, John K., Buck, Kari J.

“…Behavioral and pharmacological responses of selectively bred and inbred rodent lines have been analyzed to elucidate many features of drug sensitivity and the…”
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Expression profiling identifies strain‐specific changes associated with ethanol withdrawal in mice by Daniels, G. M., Buck, K. J.

“…Mice that exhibit characteristics of physical dependence following ethanol exposure serve as useful models of alcoholism in humans. The DBA/2 J and C57BL/6 J…”
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Chimeric Dopamine-Norepinephrine Transporters Delineate Structural Domains Influencing Selectivity for Catecholamines and 1-Methyl-4-Phenylpyridinium by Buck, Kari J., Amara, Susan G.

“…The dopamine (DA) and norephinephrine (NE) transporters demonstrate important differences in their selectivity for catecholamines and the parkinsonism-inducing…”
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Fine mapping of a sedative‐hypnotic drug withdrawal locus on mouse chromosome 11 by Hood, H. M., Metten, P., Crabbe, J. C., Buck, K. J.

“…We have established that there is a considerable amount of common genetic influence on physiological dependence and associated withdrawal from…”
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Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants by Buck, K J, Amara, S G

“…Reuptake systems for monoamines are the initial sites of action for a wide range of therapeutic antidepressants and drugs of abuse, such as cocaine. To…”
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Mpdz expression in the caudolateral substantia nigra pars reticulata is crucially involved in alcohol withdrawal by Kruse, L. C., Walter, N. A. R., Buck, K. J.

“…Association studies implicate the multiple PDZ domain protein (MUPP1/MPDZ) gene in risk for alcoholism in humans and alcohol withdrawal in mice. Although…”
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Genetic variability of respiratory complex abundance, organization and activity in mouse brain by Buck, K. J., Walter, N. A. R., Denmark, D. L.

“…Mitochondrial dysfunction is implicated in the etiology and pathogenesis of numerous human disorders involving tissues with high energy demand. Murine models…”
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Rostroventral caudate putamen involvement in ethanol withdrawal is influenced by a chromosome 4 locus by Chen, G., Buck, K. J.

“…Physiological dependence and associated withdrawal episodes are thought to constitute a motivational force that sustains alcohol use and abuse and may…”
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Potential pleiotropic effects of Mpdz on vulnerability to seizures by Fehr, C., Shirley, R. L., Metten, P., Kosobud, A. E. K., Belknap, J. K., Crabbe, J. C., Buck, K. J.

“…We previously mapped quantitative trait loci (QTL) responsible for approximately 26% of the genetic variance in acute alcohol and barbiturate (i.e.,…”
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Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption by Phillips, T J, Belknap, J K, Buck, K J, Cunningham, C L

“…Quantitative trait locus (QTL) mapping efforts in alcohol (ethanol) research are beginning to generate promising data that may ultimately lead to the…”
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Molecular analyses and identification of promising candidate genes for loci on mouse chromosome 1 affecting alcohol physical dependence and associated withdrawal by Denmark, D. L., Buck, K. J.

“…We recently mapped quantitative trait loci (QTLs) with large effects on predisposition to physical dependence and associated withdrawal severity following…”
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Reversal of alcohol dependence and tolerance by a single administration of flumazenil by Buck, K J, Heim, H, Harris, R A

“…Chronic exposure to ethanol is associated with the development of tolerance to the acute effects of ethanol and a withdrawal syndrome characterized by anxiety…”
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Mapping a locus for alcohol physical dependence and associated withdrawal to a 1.1 Mb interval of mouse chromosome 1 syntenic with human chromosome 1q23.2‐23.3 by Kozell, L., Belknap, J. K., Hofstetter, J. R., Mayeda, A., Buck, K. J.

“…Physiological dependence and associated withdrawal episodes are thought to constitute a motivational force perpetuating continued alcohol use/abuse. Although…”
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Strategies for mapping and identifying quantitative trait loci specifying behavioral responses to alcohol by Buck, K J

“…Most responses to alcohol in both humans and animals are heritable, and this genetic sensitivity to ethanol is determined by multiple genes. However, the…”
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Congenic Mapping of Alcohol and Pentobarbital Withdrawal Liability Loci to a <1 Centimorgan Interval of Murine Chromosome 4: Identification of Mpdz as a Candidate Gene by Fehr, Christoph, Shirley, Renee L, Belknap, John K, Crabbe, John C, Buck, Kari J

“…Risk for onset of alcoholism is related to genetic differences in acute alcohol withdrawal liability. We previously mapped a locus responsible for 26% of the…”
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Quantitative Trait Loci Involved in Genetic Predisposition to Acute Alcohol Withdrawal in Mice by Buck, Kari Johnson, Metten, Pamela, Belknap, John K, Crabbe, John C

“…Alcohol dependence (alcoholism) is accompanied by evidence of tolerance, withdrawal (physiological dependence), or compulsive behavior related to alcohol use…”
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Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice by Buck, Kari J., Finn, Deborah A.

“…Quantitative trait locus (QTL) mapping has allowed dramatic progress toward the detection and chromosome mapping of minor and major gene loci involved in…”
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Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity by Buck, K J, McQuilkin, S J, Harris, R A

“…To determine whether genetic differences in development of ethanol dependence are related to changes in gamma-aminobutyric acidA (GABAA) receptor function, we…”
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