Search Results - "Buck, Jill"

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial by Chiocca, E Antonio, Yu, John S, Lukas, Rimas V, Solomon, Isaac H, Ligon, Keith L, Nakashima, Hiroshi, Triggs, Daniel A, Reardon, David A, Wen, Patrick, Stopa, Brittany M, Naik, Ajay, Rudnick, Jeremy, Hu, Jethro L, Kumthekar, Priya, Yamini, Bakhtiar, Buck, Jill Y, Demars, Nathan, Barrett, John A, Gelb, Arnold B, Zhou, John, Lebel, Francois, Cooper, Laurence J N

“…Human interleukin-12 (hIL-12) is a cytokine with anticancer activity, but its systemic application is limited by toxic inflammatory responses. We assessed the…”
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Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial by Chiocca, E Antonio, Gelb, Arnold B, Chen, Clark C, Rao, Ganesh, Reardon, David A, Wen, Patrick Y, Bi, Wenya Linda, Peruzzi, Pierpaolo, Amidei, Christina, Triggs, Dan, Seften, Leah, Park, Grace, Grant, James, Truman, Kyla, Buck, Jill Y, Hadar, Nira, Demars, Nathan, Miao, John, Estupinan, Taylor, Loewy, John, Chadha, Kamal, Tringali, Joseph, Cooper, Laurence, Lukas, Rimas V

“…Veledimex (VDX)-regulatable interleukin-12 (IL-12) gene therapy in recurrent glioblastoma (rGBM) was reported to show tumor infiltration of CD8+ T cells,…”
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PICASSO III: A Phase III, Placebo-Controlled Study of Doxorubicin With or Without Palifosfamide in Patients With Metastatic Soft Tissue Sarcoma by Ryan, Christopher W, Merimsky, Ofer, Agulnik, Mark, Blay, Jean-Yves, Schuetze, Scott M, Van Tine, Brian A, Jones, Robin L, Elias, Anthony D, Choy, Edwin, Alcindor, Thierry, Keedy, Vicki L, Reed, Damon R, Taub, Robert N, Italiano, Antoine, Garcia Del Muro, Xavier, Judson, Ian R, Buck, Jill Y, Lebel, Francois, Lewis, Jonathan J, Maki, Robert G, Schöffski, Patrick

“…Purpose Palifosfamide is the active metabolite of ifosfamide and does not require prodrug activation, thereby avoiding the generation of toxic metabolites. The…”
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An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations by Dube, Umber, Del-Aguila, Jorge L, Li, Zeran, Budde, John P, Jiang, Shan, Hsu, Simon, Ibanez, Laura, Fernandez, Maria Victoria, Farias, Fabiana, Norton, Joanne, Gentsch, Jen, Wang, Fengxian, Salloway, Stephen, Masters, Colin L, Lee, Jae-Hong, Graff-Radford, Neill R, Chhatwal, Jasmeer P, Bateman, Randall J, Morris, John C, Karch, Celeste M, Harari, Oscar, Cruchaga, Carlos

“…Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; n control  = 13; n AD  = 83) from the…”
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Social Stressors and Strain Among Police Officers: It’s Not Just the Bad Guys by Adams, Gary A., Buck, Jill

“…This study examined the relationships of social stressors arising from interactions with civilians and suspects (outsiders) and coworkers and supervisors…”
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ATIM-25. PD-1 INHIBITION CAN BE COMBINED WITH IL-12 IN SUBJECTS WITH RECURRENT GLIOBLASTOMA by Chiocca, Ennio, Lukas, Rimas, Rao, Ganesh, Buck, Jill, Demars, Nathan, Smith, Amy, Miao, John, Zhou, John, Gelb, Arnold, Cooper, Laurence

“…Abstract Monotherapy with intratumoral Ad-RTS-hIL-12 (Ad), a novel gene therapeutic conditionally expressing IL-12 under the transcriptional control of oral…”
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Evaluation of controlled IL-12 in combination with a PD-1 inhibitor in subjects with recurrent glioblastoma by Chiocca, E. Antonio, Lukas, Rimas Vincas, Rao, Ganesh, Barrett, John A., Buck, Jill Y., Demars, Nathan, Smith, Amy, Miao, John, Zhou, Qiang (John), Gelb, Arnold Bruce, Cooper, Laurence

“…Abstract only 2020 Background: Ad-RTS-hIL-12 (Ad) is a novel gene therapy candidate conditionally expressing IL-12 under the control of veledimex (V) acting…”
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CTIM-27. PHASE I/II STUDY OF CONTROLLED IL-12 AS IMMUNOTHERAPY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) by Goldman, Stewart, Mueller, Sabine, Chi, Susan, Saratsis, Amanda, Allen, Rudy, Buck, Jill, Demars, Nathan, Hadar, Nira, Estupinan, Taylor, Miao, John, Walsh, Erin, Gelb, Arnold, Cooper, Laurence

“…Abstract DIPG, which is the leading cause of pediatric brain cancer death with no effective treatment, has neither a highly immunosuppressive nor inflammatory…”
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Final results of controlled IL-12 monotherapy in adults with grade III or IV gliomas by Chiocca, E. Antonio, Lukas, Rimas Vincas, Yu, John, Yamini, Bakhtiar, Oberheim Bush, Nancy Ann, Amidei, Christina, Buck, Jill Yannetti, Demars, Nathan A., Hadar, Nira, Miao, John, Estupinan, Taylor, Wang, Yunxia, Loewy, John W., Gelb, Arnold Bruce, Cooper, Laurence JN

“…Abstract only 3040 Background: Interleukin-12 (IL-12), a master regulator of the immune system, results in anti-tumor responses in preclinical models, but safe…”
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Survival of subjects with recurrent glioblastoma receiving intratumoral administration of controlled IL-12 with limited exposure to dexamethasone by Lukas, Rimas Vincas, Kurz, Sylvia Christine, Yu, John, Landolfi, Joseph C., Rao, Ganesh, Amidei, Christina, Buck, Jill Yannetti, Hadar, Nira, Estupinan, Taylor, Miao, John, Loewy, John W., Wang, Yunxia, Demars, Nathan A., Gelb, Arnold Bruce, Cooper, Laurence JN

“…Abstract only 2564 Background: Interleukin-12 (IL-12) results in anti-tumor responses in preclinical models but requires tightly controlled production to…”
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Controlled IL-12 in combination with a PD-1 inhibitor subjects with recurrent glioblastoma by Chiocca, E. Antonio, Lukas, Rimas Vincas, Chen, Clark C, Rao, Ganesh, Amidei, Christina, Buck, Jill Yannetti, Hadar, Nira, Demars, Nathan A., Miao, John, Estupinan, Taylor, Loewy, John W., Wang, Yunxia, Gelb, Arnold Bruce, Cooper, Laurence JN

“…Abstract only 2510 Background: Monotherapy with intratumoral Ad-RTS-hIL-12 (Ad), a gene therapeutic conditionally expressing IL-12 under the transcriptional…”
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CTIM-20. FINAL RESULTS OF CONTROLLED IL-12 MONOTHERAPY AND IN COMBINATION WITH PD-1 INHIBITOR IN ADULT SUBJECTS WITH RECURRENT GLIOBLASTOMA by Lukas, Rimas, Oberheim-Bush, Nancy Ann, Cavaliere, Robert, Landolfi, Joseph, Yu, John S, Chen, Clark, Cordova, Christine, Amidei, Christina, Buck, Jill Y, Hadar, Nira, Demars, Nate, Miao, John, Loewy, John, Estupinan, Taylor, Chadha, Kamal, Cooper, Laurence J N, Chiocca, E Antonio

“…Abstract Ad-RTS-hIL-12(Ad) is a gene therapy candidate conditionally expressing IL-12 under the transcriptional control of veledimex(V) acting via the…”
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PDCT-03. PHASE 1 STUDY OF Ad-RTS-hIL-12 + VELEDIMEX IN PEDIATRIC BRAIN TUMORS by Goldman, Stewart, Kieran, Mark, Mueller, Sabine, Buck, Jill, MacKenna, Richard, Barrett, John, Cooper, Laurence, Lebel, Francois

“…Pediatric glioblastoma has an aggressive clinical course accounting for significant morbidity and mortality among children with brain tumors. Only 10% of…”
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Demonstration of anti-tumor immunity via intratumoral regulated platform ad-RTS-hIL-12 in advanced breast cancer and recurrent glioblastoma patients by Lebel, Francois M., Barrett, John A, McArthur, Heather L., Buck, Jill Y., Demars, Nathan, Mackenna, Rich, Cooper, Laurence JN, Chiocca, E. Antonio

“…Abstract only…”
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ATIM-18. SURVIVAL OF SUBJECTS WITH RECURRENT GLIOBLASTOMA RECEIVING INTRA-TUMORAL ADMINISTRATION OF IL-12 MANAGED WITH LOW-DOSE DEXAMETHASONE by Lukas, Rimas, Chiocca, Ennio, Kurz, Sylvia, Yu, John, Landolfi, Joseph, Rao, Ganesh, Buck, Jill, Demars, Nathan, Smith, Amy, Miao, John, Zhou, John, Wang, Yunxia, Gelb, Arnold, Cooper, Laurence

“…Abstract Ad-RTS-hIL-12 (Ad) is a novel gene therapy, conditionally expressing IL-12 via the RheoSwitch Therapeutic System® (RTS®) gene switch under control of…”
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Evaluation of controlled IL-12 as monotherapy in subjects with recurrent GBM by Lukas, Rimas Vincas, Chiocca, E. Antonio, Kurz, Sylvia Christine, Yu, John, Landolfi, Joseph C., Rao, Ganesh, Barrett, John A., Buck, Jill Y., Demars, Nathan, Smith, Amy, Miao, John, Zhou, Qiang (John), Gelb, Arnold Bruce, Cooper, Laurence

“…Abstract only 2053 Background: Interleukin-12 (IL-12), a master regulator of the immune system, results in anti-tumor responses in preclinical models, but safe…”
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CTIM-28. PHASE 2 TRIAL OF CONTROLLED IL-12 IN COMBINATION WITH PD-1 INHIBITOR IN ADULT SUBJECTS WITH RECURRENT GLIOBLASTOMA (rGBM) by Lukas, Rimas, Chiocca, E Antonio, Bush, Nancy Ann Oberheim, Landolfi, Joseph, Cavaliere, Robert, Yu, John, Kurz, Sylvia, Demars, Nathan, Buck, Jill, Hadar, Nira, Miao, John, Loewy, John, Wang, Yunxia, Gelb, Arnold, Cooper, Laurence

“…Abstract Ad-RTS-hIL-12 (Ad) is a gene therapy candidate for intratumoral (IT) delivery that conditionally expresses IL-12 (IL-12) under the transcriptional…”
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CTIM-05. COMBINATION OF CONTROLLED INTERLEUKIN-12 GENE THERAPY WITH IMMUNE CHECKPOINT BLOCKADE IN RECURRENT GLIOBLASTOMA: UPDATED RESULTS OF A MULTI-INSTITUTIONAL, OPEN LABEL PHASE 1 TRIAL by Antonio Chiocca, E, Lukas, Rimas, Chen, Clark, Rao, Ganesh, Amidei, Christina, Buck, Jill, Hadar, Nira, Demars, Nathan, Miao, John, Estupinan, Taylor, Loewy, John, Wang, Yunxia, Gelb, Arnold, Cooper, Laurence

“…Abstract A published clinical trial of veledimex (V)-regulatable interleukin-12 (IL-12) gene therapy (“Controlled IL-12”) under the control of a…”
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Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid by Drieu, Antoine, Du, Siling, Storck, Steffen E., Rustenhoven, Justin, Papadopoulos, Zachary, Dykstra, Taitea, Zhong, Fenghe, Kim, Kyungdeok, Blackburn, Susan, Mamuladze, Tornike, Harari, Oscar, Karch, Celeste M., Bateman, Randall J., Perrin, Richard, Farlow, Martin, Chhatwal, Jasmeer, Brosch, Jared, Buck, Jill, Farlow, Marty, Ghetti, Bernardino, Adams, Sarah, Barthelemy, Nicolas, Benzinger, Tammie, Brandon, Susan, Buckles, Virginia, Cash, Lisa, Chen, Charlie, Chua, Jasmin, Cruchaga, Carlos, Denner, Darcy, Dincer, Aylin, Donahue, Tamara, Fagan, Anne, Feldman, Becca, Flores, Shaney, Franklin, Erin, Joseph-Mathurin, Nelly, Gonzalez, Alyssa, Gordon, Brian, Gray, Julia, Gremminger, Emily, Groves, Alex, Hassenstab, Jason, Hellm, Cortaiga, Herries, Elizabeth, Hoechst-Swisher, Laura, Holtzman, David, Hornbeck, Russ, Jerome, Gina, Keefe, Sarah, Koudelis, Deb, Li, Yan, Marsh, Jacob, Martinez, Rita, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Morris, John, Norton, Joanne, Shady, Kristine, Sigurdson, Wendy, Smith, Jennifer, Wang, Peter, Wang, Qing, Xiong, Chengjie, Xu, Jinbin, Xu, Xiong, Allegri, Ricardo, Mendez, Patricio Chrem, Egido, Noelia, Araki, Aki, Ikeuchi, Takeshi, Ishii, Kenji, Kasuga, Kensaku, Bechara, Jacob, Brooks, William, Schofield, Peter, Berman, Sarah, Goldberg, Sarah, Ikonomovic, Snezana, Klunk, William, Lopez, Oscar, Mountz, James, Nadkarni, Neelesh, Patira, Riddhi, Smith, Lori, Snitz, Beth, Thompson, Sarah, Weamer, Elise, Bodge, Courtney, Salloway, Stephen, Carter, Kathleen, Duong, Duc, Johnson, Erik, Levey, Allan, Ping, Lingyan, Seyfried, Nicholas T., Fitzpatrick, Colleen, Chui, Helena, Ringman, John

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ATIM-26. A PHASE 1 STUDY OF Ad-RTS-hIL-12 + VELEDIMEX IN ADULT RECURRENT GLIOBLASTOMA by Chiocca, E Antonio, Yu, John, Lukas, Rimas V, Buck, Jill, Demars, Nate, Barrett, John, Yang, Yijun, Cooper, Laurence, Lebel, Francois

“…Glioblastoma (GBM) is an aggressive brain tumor affecting ~74,000 people worldwide annually. Recurrent GBM patients have a median overall survival (mOS) of…”
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