Search Results - "Buchrieser, Julian"
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Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells
Published in Nature communications (25-03-2021)“…Extracellular vesicles (EVs), including exosomes, are thought to mediate intercellular communication through the transfer of cargoes from donor to acceptor…”
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Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies
Published in Nature Medicine (01-05-2021)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.7 and B.1.351 variants were first identified in the United Kingdom and South Africa,…”
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Syncytia formation by SARS‐CoV‐2‐infected cells
Published in The EMBO journal (01-12-2020)“…Severe cases of COVID‐19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. The viral and cellular…”
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IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise
Published in Science (American Association for the Advancement of Science) (12-07-2019)“…Elevated levels of type I interferon (IFN) during pregnancy are associated with intrauterine growth retardation, preterm birth, and fetal demise through…”
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Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages
Published in Stem cell reports (14-02-2017)“…Tissue-resident macrophages, such as microglia, Kupffer cells, and Langerhans cells, derive from Myb-independent yolk sac (YS) progenitors generated before the…”
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Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry
Published in Nature communications (26-01-2022)“…HIV elite controllers maintain a population of CD4 + T cells endowed with high avidity for Gag antigens and potent effector functions. How these HIV-specific…”
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A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response
Published in Stem cell reports (06-06-2017)“…Microglia are increasingly implicated in brain pathology, particularly neurodegenerative disease, with many genes implicated in Alzheimer's, Parkinson's, and…”
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Syncytia formation by SARS‐CoV‐2‐infected cells
Published in The EMBO journal (01-02-2021)Get full text
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Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion
Published in Nature communications (13-03-2024)“…The unceasing circulation of SARS-CoV-2 leads to the continuous emergence of novel viral sublineages. Here, we isolate and characterize XBB.1, XBB.1.5,…”
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Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein
Published in Nature communications (30-01-2020)“…Rabies virus (RABV) causes fatal encephalitis in more than 59,000 people yearly. Upon the bite of an infected animal, the development of clinical disease can…”
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SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
Published in Nature communications (28-07-2021)“…SAMHD1 is a cellular triphosphohydrolase (dNTPase) proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting the supply of the…”
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Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus
Published in Journal of extracellular vesicles (01-12-2020)“…SARS‐CoV‐2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by host TMPRSS2 allowing membrane fusion…”
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Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling
Published in Nature communications (11-06-2024)“…Assessing the impact of SARS-CoV-2 on organelle dynamics allows a better understanding of the mechanisms of viral replication. We combine label-free…”
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Atlastin Endoplasmic Reticulum-Shaping Proteins Facilitate Zika Virus Replication
Published in Journal of virology (01-12-2019)“…The endoplasmic reticulum (ER) is the site for Zika virus (ZIKV) replication and is central to the cytopathic effects observed in infected cells. ZIKV induces…”
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Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies
Published in Cell reports. Medicine (18-05-2021)“…Many SARS-CoV-2-infected individuals remain asymptomatic. Little is known about the extent and quality of their antiviral humoral response. Here, we analyze…”
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IFITM1 inhibits trophoblast invasion and is induced in placentas associated with IFN-mediated pregnancy diseases
Published in iScience (21-07-2023)“…Interferon-induced transmembrane proteins (IFITMs) are restriction factors that block many viruses from entering cells. High levels of type I interferon (IFN)…”
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Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2
Published in EBioMedicine (01-03-2022)“…SARS-CoV-2 lineages are continuously evolving. As of December 2021, the AY.4.2 Delta sub-lineage represented 20 % of sequenced strains in the UK and had been…”
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The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation
Published in Journal of molecular biology (30-03-2022)“…[Display omitted] •SARS-CoV-2 spike (S) protein interacts with the ACE2 receptor to induce virus-cell and cell–cell fusion and this process is augmented by the…”
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Identification of a Novel Neuropathogenic Theiler's Murine Encephalomyelitis Virus
Published in Journal of Virology (01-07-2011)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pregnancy complications and Interferon-induced transmembrane proteins (IFITM): balancing antiviral immunity and placental development
Published in Comptes rendus. Biologies (01-01-2021)“…Pregnancy complications occur frequently and are particularly prevalent during the first trimester. They are caused by a multitude of factors, including…”
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