Search Results - "Buchner, Johannes"

Collaborative Nested Sampling: Big Data versus Complex Physical Models by Buchner, Johannes

“…The data torrent unleashed by current and upcoming astronomical surveys demands scalable analysis methods. Many machine learning approaches scale well, but…”
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A statistical test for Nested Sampling algorithms by Buchner, Johannes

“…Nested sampling is an iterative integration procedure that shrinks the prior volume towards higher likelihoods by removing a “live” point at a time. A…”
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Molecular chaperones and protein quality control: an introduction to the JBC Reviews thematic series by Buchner, Johannes

“…Protein folding is a spontaneous process. However, under physiological conditions, proteins are inherently unstable, and the protein concentrations in living…”
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Small heat shock proteins: Simplicity meets complexity by Haslbeck, Martin, Weinkauf, Sevil, Buchner, Johannes

“…Small heat shock proteins (sHsps) are a ubiquitous and ancient family of ATP-independent molecular chaperones. A key characteristic of sHsps is that they exist…”
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The Heat Shock Response: Life on the Verge of Death by Richter, Klaus, Haslbeck, Martin, Buchner, Johannes

“…Organisms must survive a variety of stressful conditions, including sudden temperature increases that damage important cellular structures and interfere with…”
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Galaxy gas as obscurer – II. Separating the galaxy-scale and nuclear obscurers of active galactic nuclei by Buchner, Johannes, Bauer, Franz E

“…The 'torus' obscurer of active galactic nuclei (AGN) is poorly understood in terms of its density, sub-structure and physical mechanisms. Large X-ray surveys…”
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The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones by Li, Jing, Soroka, Joanna, Buchner, Johannes

“…Hsp90 is a dimeric molecular chaperone required for the activation and stabilization of numerous client proteins many of which are involved in essential…”
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Structure, function and regulation of the hsp90 machinery by Li, Jing, Buchner, Johannes

“…Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone which is essential in eukaryotes. It is required for the activation and stabilization of…”
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The chaperone Hsp90: changing partners for demanding clients by Röhl, Alina, Rohrberg, Julia, Buchner, Johannes

“…The heat shock protein (Hsp)90 chaperone machinery regulates the activity of hundreds of client proteins in the eukaryotic cytosol. It undergoes large…”
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Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90 by Richter, Klaus, Buchner, Johannes, Hessling, Martin

“…The Hsp90 chaperone is responsible for the stabilization of a large variety of regulatory proteins. By labeling the subunits in the Hsp90 homodimer with…”
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Bacterial Hsp90 - desperately seeking clients by Buchner, Johannes

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Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments by Jahn, Markus, Buchner, Johannes, Hugel, Thorsten, Rief, Matthias

“…Folding of small proteins often occurs in a two-state manner and is well understood both experimentally and theoretically. However, many proteins are much…”
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Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle by Li, Jing, Richter, Klaus, Reinstein, Jochen, Buchner, Johannes

“…The role of co-chaperone and Hsp90 activator Aha1 is now examined in conjunction with other co-chaperones in vivo and in vitro , to reveal how they regulate…”
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The Plasticity of the Hsp90 Co-chaperone System by Sahasrabudhe, Priyanka, Rohrberg, Julia, Biebl, Maximillian M., Rutz, Daniel A., Buchner, Johannes

“…The Hsp90 system in the eukaryotic cytosol is characterized by a cohort of co-chaperones that bind to Hsp90 and affect its function. Although progress has been…”
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Dissection of the amyloid formation pathway in AL amyloidosis by Kazman, Pamina, Absmeier, Ramona M., Engelhardt, Harald, Buchner, Johannes

“…In antibody light chain (AL) amyloidosis, overproduced light chain (LC) fragments accumulate as fibrils in organs and tissues of patients. In vitro, AL fibril…”
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The Accretion History of AGNs. I. Supermassive Black Hole Population Synthesis Model by Tasnim Ananna, Tonima, Treister, Ezequiel, Megan Urry, C., Ricci, C., Kirkpatrick, Allison, LaMassa, Stephanie, Buchner, Johannes, Civano, Francesca, Tremmel, Michael, Marchesi, Stefano

“…As matter accretes onto the central supermassive black holes in active galactic nuclei (AGNs), X-rays are emitted. We present a population synthesis model that…”
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Coordinated Conformational Processing of the Tumor Suppressor Protein p53 by the Hsp70 and Hsp90 Chaperone Machineries by Dahiya, Vinay, Agam, Ganesh, Lawatscheck, Jannis, Rutz, Daniel Andreas, Lamb, Don C., Buchner, Johannes

“…p53, the guardian of the genome, requires chaperoning by Hsp70 and Hsp90. However, how the two chaperone machineries affect p53 conformation and regulate its…”
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Hsp90 Co-chaperones Form Plastic Genetic Networks Adapted to Client Maturation by Biebl, Maximilian M., Riedl, Maximilian, Buchner, Johannes

“…Heat shock protein 90 (Hsp90) is a molecular chaperone regulating the activity of diverse client proteins together with a plethora of different co-chaperones…”
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A Revisit of the Mass–Metallicity Trends in Transiting Exoplanets by Sun, Qinghui, Wang, Sharon Xuesong, Welbanks, Luis, Teske, Johanna, Buchner, Johannes

“…Abstract The two prevailing planet formation scenarios, core accretion and disk instability, predict distinct planetary mass–metallicity relations. Yet, the…”
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Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants by Dashivets, Tetyana, Thomann, Marco, Rueger, Petra, Knaupp, Alexander, Buchner, Johannes, Schlothauer, Tilman

“…Therapeutic performance of recombinant antibodies relies on two independent mechanisms: antigen recognition and Fc-mediated antibody effector functions…”
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