Search Results - "Buchholz, John N"

Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway by Xiao, Daliao, Buchholz, John N, Zhang, Lubo

“…The mechanisms of adaptation of uterine artery vascular tone to pregnancy are not fully understood. The present study tested the hypothesis that pregnancy…”
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Cerebral autoregulation is minimally influenced by the superior cervical ganglion in two- week-old lambs, and absent in preterm lambs immediately following delivery by Czynski, Adam J, Terry, Michael H, Deming, Douglas D, Power, Gordon G, Buchholz, John N, Blood, Arlin B

“…Cerebral vessels in the premature newborn brain are well supplied with adrenergic nerves, stemming from the superior cervical ganglia (SCG), but their role in…”
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Aging Alters Cerebrovascular Endothelial GPCR and K+ Channel Function: Divergent Role of Biological Sex by Hakim, Md A, Chum, Phoebe P, Buchholz, John N, Behringer, Erik J

“…Abstract Age-related dementia entails impaired blood flow to and throughout the brain due, in part, to reduced endothelial nitric oxide signaling. However, it…”
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Age‐dependent changes in Ca2+ homeostasis in peripheral neurones: implications for changes in function by Buchholz, John N., Behringer, Erik J., Pottorf, William J., Pearce, William J., Vanterpool, Conwin K.

“…Summary Calcium ions represent universal second messengers within neuronal cells integrating multiple cellular functions, such as release of neurotransmitters,…”
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Foetal nicotine exposure causes PKCε gene repression by promoter methylation in rat hearts by Lawrence, Jennifer, Chen, Man, Xiong, Fuxia, Xiao, Daliao, Zhang, Haitao, Buchholz, John N, Zhang, Lubo

“…foetal nicotine exposure results in decreased protein kinase C epsilon (PKCε) expression and increased cardiac vulnerability to ischaemia and reperfusion…”
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Maternal food restriction modulates cerebrovascular structure and contractility in adult rat offspring: effects of metyrapone by Durrant, Lara M, Khorram, Omid, Buchholz, John N, Pearce, William J

“…Although the effects of prenatal undernutrition on adult cardiovascular health have been well studied, its effects on the cerebrovascular structure and…”
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Maturation depresses mouse cerebrovascular tone through endothelium-dependent mechanisms by Geary, Greg G, Buchholz, John N, Pearce, William J

“…In light of previous observations that the range of arterial pressures over which cerebral blood flow is autoregulated differs dramatically in neonates and…”
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Electrical dynamics of isolated cerebral and skeletal muscle endothelial tubes: Differential roles of G‐protein‐coupled receptors and K+ channels by Hakim, Md A., Buchholz, John N., Behringer, Erik J.

“…Electrical dynamics of freshly isolated cerebral endothelium have not been determined independently of perivascular nerves and smooth muscle. We tested the…”
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Maternal high-altitude hypoxia and suppression of ryanodine receptor-mediated Ca2+ sparks in fetal sheep pulmonary arterial myocytes by Hadley, Scott R, Blood, Quintin, Rubalcava, Monica, Waskel, Edith, Lumbard, Britney, Le, Petersen, Longo, Lawrence D, Buchholz, John N, Wilson, Sean M

“…Ca(2+) sparks are fundamental Ca(2+) signaling events arising from ryanodine receptor (RyR) activation, events that relate to contractile and dilatory events…”
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Roles of cytosolic Ca2+ concentration and myofilament Ca2+ sensitization in age-dependent cerebrovascular myogenic tone by Charles, Shelton M, Zhang, Lubo, Cipolla, Marilyn J, Buchholz, John N, Pearce, William J

“…In light of evidence that immature arteries contain a higher proportion of noncontractile smooth muscle cells than found in fully differentiated mature…”
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Selected Contribution: Effects of aging on cerebrovascular tone and [Ca2+]i by Geary, Greg G, Buchholz, John N

“…Department of Physiology and Pharmacology, School of Medicine, Loma Linda University, Loma Linda, California 92350 Submitted 27 March 2003 ; accepted in final…”
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Enhanced capacitative calcium entry and sarcoplasmic-reticulum calcium storage capacity with advanced age in murine mesenteric arterial smooth muscle cells by Goyal, Ravi, Angermann, Jeff E., Ostrovskaya, Olga, Buchholz, John N., Smith, Gregory D., Wilson, Sean M.

“…Intracellular Ca 2+ signaling is important to perfusion pressure related arterial reactivity and to vascular disorders including hypertension, angina and…”
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Advancing age alters the expression of the ryanodine receptor 3 isoform in adult rat superior cervical ganglia by Vanterpool, Conwin K, Vanterpool, Elaine A, Pearce, William J, Buchholz, John N

“…1 Department of Physiology and Pharmacology and 2 Department of Microbiology and Molecular Genetics, Loma Linda University, School of Medicine, Loma Linda,…”
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Decreased NR1 phosphorylation and decreased NMDAR function in hibernating Arctic ground squirrels by Zhao, Huiwen W., Ross, Austin P., Christian, Sherri L., Buchholz, John N., Drew, Kelly L.

“…Heterothermic mammals such as ground squirrels tolerate ischemia and N‐methyl‐D‐aspartate (NMDA) better than homeothermic mammals such as rats both in vivo and…”
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Postnatal maturation attenuates pressure-evoked myogenic tone and stretch-induced increases in Ca2+ in rat cerebral arteries by Charles, Shelton M, Zhang, Lubo, Longo, Lawrence D, Buchholz, John N, Pearce, William J

“…Although postnatal maturation potently modulates agonist-induced cerebrovascular contractility, its effects on the mechanisms mediating cerebrovascular…”
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Maturation and long-term hypoxia alters Ca2+-induced Ca2+ release in sheep cerebrovascular sympathetic neurons by Behringer, Erik J, Leite, Laura D, Buchholz, Nickolaus E, Keeney, Michael G, Pearce, William J, Vanterpool, Conwin K, Wilson, Sean M, Buchholz, John N

“…1 Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California; ; 2 Departamento de Ciências Fisiológicas,…”
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Advancing age alters rapid and spontaneous refilling of caffeine-sensitive calcium stores in sympathetic superior cervical ganglion cells by Vanterpool, Conwin K, Pearce, William J, Buchholz, John N

“…Department of Physiology and Pharmacology, Loma Linda University, School of Medicine, Loma Linda, California Submitted 24 March 2005 ; accepted in final form…”
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Advancing Age Alters the Contribution of Calcium Release From Smooth Endoplasmic Reticulum Stores in Superior Cervical Ganglion Cells by Behringer, Erik J., Vanterpool, Conwin K., Pearce, William J., Wilson, Sean M., Buchholz, John N.

“…In superior cervical ganglion (SCG) neurons calcium-induced calcium release (CICR), mediated by ryanodine receptors (RyRs), contributes to stimulation-evoked…”
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Alteration of Calcium and Electrical Dynamics in Cerebrovascular Endothelium During Development of Alzheimer's disease by Hakim, Md A., Buchholz, John N., Behringer, Erik J.

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia characterized by a decline in cognitive function…”
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Aging and calcium buffering in adrenergic neurons by Pottorf, William J, Duckles, Sue P, Buchholz, John N

“…The aging process at the cellular, organ and whole organism levels is in many respects a mystery. A common bias among those who study aging is that cellular…”
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