Search Results - "Buchholz, David"

A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic by Shapira, Tirosh, Monreal, I. Abrrey, Dion, Sébastien P., Buchholz, David W., Imbiakha, Brian, Olmstead, Andrea D., Jager, Mason, Désilets, Antoine, Gao, Guang, Martins, Mathias, Vandal, Thierry, Thompson, Connor A. H., Chin, Aaleigha, Rees, William D., Steiner, Theodore, Nabi, Ivan Robert, Marsault, Eric, Sahler, Julie, Diel, Diego G., Van de Walle, Gerlinde R., August, Avery, Whittaker, Gary R., Boudreault, Pierre-Luc, Leduc, Richard, Aguilar, Hector C., Jean, François

“…The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their…”
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Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat by Carr, Amanda-Jayne, Vugler, Anthony A, Hikita, Sherry T, Lawrence, Jean M, Gias, Carlos, Chen, Li Li, Buchholz, David E, Ahmado, Ahmad, Semo, Ma'ayan, Smart, Matthew J K, Hasan, Shazeen, da Cruz, Lyndon, Johnson, Lincoln V, Clegg, Dennis O, Coffey, Pete J

“…Transformation of somatic cells with a set of embryonic transcription factors produces cells with the pluripotent properties of embryonic stem cells (ESCs)…”
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Ecology, evolution and spillover of coronaviruses from bats by Ruiz-Aravena, Manuel, McKee, Clifton, Gamble, Amandine, Lunn, Tamika, Morris, Aaron, Snedden, Celine E., Yinda, Claude Kwe, Port, Julia R., Buchholz, David W., Yeo, Yao Yu, Faust, Christina, Jax, Elinor, Dee, Lauren, Jones, Devin N., Kessler, Maureen K., Falvo, Caylee, Crowley, Daniel, Bharti, Nita, Brook, Cara E., Aguilar, Hector C., Peel, Alison J., Restif, Olivier, Schountz, Tony, Parrish, Colin R., Gurley, Emily S., Lloyd-Smith, James O., Hudson, Peter J., Munster, Vincent J., Plowright, Raina K.

“…In the past two decades, three coronaviruses with ancestral origins in bats have emerged and caused widespread outbreaks in humans, including severe acute…”
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Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells by Buchholz, David E., Hikita, Sherry T., Rowland, Teisha J., Friedrich, Amy M., Hinman, Cassidy R., Johnson, Lincoln V., Clegg, Dennis O.

“…Human induced pluripotent stem cells (iPSCs) have great promise for cellular therapy, but it is unclear if they have the same potential as human embryonic stem…”
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Headless Henipaviral Receptor Binding Glycoproteins Reveal Fusion Modulation by the Head/Stalk Interface and Post-receptor Binding Contributions of the Head Domain by Yeo, Yao Yu, Buchholz, David W, Gamble, Amandine, Jager, Mason, Aguilar, Hector C

“…Cedar virus (CedV) is a nonpathogenic member of the (HNV) genus of emerging viruses, which includes the deadly Nipah (NiV) and Hendra (HeV) viruses. CedV forms…”
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Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin by Sundberg, Maria, Tochitsky, Ivan, Buchholz, David E., Winden, Kellen, Kujala, Ville, Kapur, Kush, Cataltepe, Deniz, Turner, Daria, Han, Min-Joon, Woolf, Clifford J., Hatten, Mary E., Sahin, Mustafa

“…Accumulating evidence suggests that cerebellar dysfunction early in life is associated with autism spectrum disorder (ASD), but the molecular mechanisms…”
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Finding proteases that make cells go viral by Aguilar, Hector C., Buchholz, David W.

“…The activation of influenza virus hemagglutinin (HA) glycoprotein via cleavage by host cell proteases is essential for viral infectivity, and understanding the…”
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Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics by Buchholz, David E., Carroll, Thomas S., Kocabas, Arif, Zhu, Xiaodong, Behesti, Hourinaz, Faust, Phyllis L., Stalbow, Lauren, Fang, Yin, Hatten, Mary E.

“…Comparative transcriptomics between differentiating human pluripotent stem cells (hPSCs) and developing mouse neurons offers a powerful approach to compare…”
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Modified Sialic Acids on Mucus and Erythrocytes Inhibit Influenza A Virus Hemagglutinin and Neuraminidase Functions by Barnard, Karen N, Alford-Lawrence, Brynn K, Buchholz, David W, Wasik, Brian R, LaClair, Justin R, Yu, Hai, Honce, Rebekah, Ruhl, Stefan, Pajic, Petar, Daugherity, Erin K, Chen, Xi, Schultz-Cherry, Stacey L, Aguilar, Hector C, Varki, Ajit, Parrish, Colin R

“…Sialic acids (Sia) are the primary receptors for influenza viruses and are widely displayed on cell surfaces and in secreted mucus. Sia may be present in…”
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Pluripotent human stem cells for the treatment of retinal disease by Rowland, Teisha J., Buchholz, David E., Clegg, Dennis O.

“…Despite advancements made in our understanding of ocular biology, therapeutic options for many debilitating retinal diseases remain limited. Stem cell‐based…”
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Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells by Behesti, Hourinaz, Kocabas, Arif, Buchholz, David E, Carroll, Thomas S, Hatten, Mary E

“…Brain development is regulated by conserved transcriptional programs across species, but little is known about the divergent mechanisms that create…”
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Rapid and Efficient Directed Differentiation of Human Pluripotent Stem Cells Into Retinal Pigmented Epithelium by Buchholz, David E., Pennington, Britney O., Croze, Roxanne H., Hinman, Cassidy R., Coffey, Peter J., Clegg, Dennis O.

“…Although protocols to generate retinal pigmented epithelium (RPE) from human pluripotent stem cells have become more efficient since the first report in 2004,…”
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Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2-infected older mice with neurological signs by Rahman, Shafaqat M, Buchholz, David W, Imbiakha, Brian, Jager, Mason C, Leach, Justin, Osborn, Raven M, Birmingham, Ann O, Dewhurst, Stephen, Aguilar, Hector C, Luebke, Anne E

“…COVID-19 can cause neurological symptoms such as fever, dizziness, and nausea. However, such neurological symptoms of SARS-CoV-2 infection have been hardly…”
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Canonical/β-catenin Wnt pathway activation improves retinal pigmented epithelium derivation from human embryonic stem cells by Leach, Lyndsay L, Buchholz, David E, Nadar, Vignesh P, Lowenstein, Stefan E, Clegg, Dennis O

“…The purpose of this study was to better understand the role canonical/β-catenin Wnt signaling plays in the differentiation of human embryonic stem cells…”
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Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection by Tang, Alan T, Buchholz, David W, Szigety, Katherine M, Imbiakha, Brian, Gao, Siqi, Frankfurter, Maxwell, Wang, Min, Yang, Jisheng, Hewins, Peter, Mericko-Ishizuka, Patricia, Leu, N Adrian, Sterling, Stephanie, Monreal, Isaac A, Sahler, Julie, August, Avery, Zhu, Xuming, Jurado, Kellie A, Xu, Mingang, Morrisey, Edward E, Millar, Sarah E, Aguilar, Hector C, Kahn, Mark L

“…Angiotensin-converting enzyme 2 (ACE2) is the cell-surface receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While its central role in…”
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Roles of Cholesterol in Early and Late Steps of the Nipah Virus Membrane Fusion Cascade by Contreras, Erik M, Johnston, Gunner P, Buchholz, David W, Ortega, Victoria, Monreal, I Abrrey, Zamora, J Lizbeth R, Cheung, Tracy, Aguilar, Hector C

“…Cholesterol has been implicated in various viral life cycle steps for different enveloped viruses, including viral entry into host cells, cell-cell fusion, and…”
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Expression of 9- O - and 7,9- O -Acetyl Modified Sialic Acid in Cells and Their Effects on Influenza Viruses by Barnard, Karen N, Wasik, Brian R, LaClair, Justin R, Buchholz, David W, Weichert, Wendy S, Alford-Lawrence, Brynn K, Aguilar, Hector C, Parrish, Colin R

“…Sialic acids (Sia) are widely displayed on the surfaces of cells and tissues. Sia come in a variety of chemically modified forms, including those with acetyl…”
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Multivalent viral particles elicit safe and efficient immunoprotection against Nipah Hendra and Ebola viruses by Ithinji, Duncan G., Buchholz, David W., Ezzatpour, Shahrzad, Monreal, I. Abrrey, Cong, Yu, Sahler, Julie, Bangar, Amandip Singh, Imbiakha, Brian, Upadhye, Viraj, Liang, Janie, Ma, Andrew, Bradel-Tretheway, Birgit, Kaza, Benjamin, Yeo, Yao Yu, Choi, Eun Jin, Johnston, Gunner P., Huzella, Louis, Kollins, Erin, Dixit, Saurabh, Yu, Shuiqing, Postnikova, Elena, Ortega, Victoria, August, Avery, Holbrook, Michael R., Aguilar, Hector C.

“…Experimental vaccines for the deadly zoonotic Nipah (NiV), Hendra (HeV), and Ebola (EBOV) viruses have focused on targeting individual viruses, although their…”
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Drivers and Distribution of Henipavirus-Induced Syncytia: What Do We Know? by Gamble, Amandine, Yeo, Yao Yu, Butler, Aubrey A, Tang, Hubert, Snedden, Celine E, Mason, Christian T, Buchholz, David W, Bingham, John, Aguilar, Hector C, Lloyd-Smith, James O

“…Syncytium formation, i.e., cell-cell fusion resulting in the formation of multinucleated cells, is a hallmark of infection by paramyxoviruses and other…”
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MicroRNA Profiling Reveals Two Distinct p53-Related Human Pluripotent Stem Cell States by Neveu, Pierre, Kye, Min Jeong, Qi, Shuping, Buchholz, David E., Clegg, Dennis O., Sahin, Mustafa, Park, In-Hyun, Kim, Kwang-Soo, Daley, George Q., Kornblum, Harley I., Shraiman, Boris I., Kosik, Kenneth S.

“…Reprogramming methodologies have provided multiple routes for achieving pluripotency. However, pluripotency is generally considered to be an almost singular…”
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