Search Results - "Buchheim, Judith‐Irina"
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Immune sensitization during 1 year in the Antarctic high‐altitude Concordia Environment
Published in Allergy (Copenhagen) (01-01-2019)“…Background Antarctica is a challenging environment for humans. It serves as a spaceflight ground analog, reflecting some conditions of long‐duration…”
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Plasticity of the human IgM repertoire in response to long‐term spaceflight
Published in The FASEB journal (01-12-2020)“…Immune dysregulation is among the main adverse outcomes of spaceflight. Despite the crucial role of the antibody repertoire in host protection, the effects of…”
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Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions
Published in Frontiers in immunology (28-06-2018)“…Recent studies have established that dysregulation of the human immune system and the reactivation of latent herpesviruses persists for the duration of a…”
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The Future of Personalized Medicine in Space: From Observations to Countermeasures
Published in Frontiers in bioengineering and biotechnology (13-12-2021)“…The aim of personalized medicine is to detach from a "one-size fits all approach" and improve patient health by individualization to achieve the best outcomes…”
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Monitoring functional immune responses with a cytokine release assay: ISS flight hardware design and experimental protocol for whole blood cultures executed under microgravity conditions
Published in Frontiers in physiology (15-01-2024)“…Long-term space missions trigger a prolonged neuroendocrine stress response leading to immune system dysregulation evidenced by susceptibility to infections,…”
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Specific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions
Published in Frontiers in immunology (11-10-2019)Get full text
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7
Assessing Stress Induced by Fluid Shifts and Reduced Cerebral Clearance during Robotic-Assisted Laparoscopic Radical Prostatectomy under Trendelenburg Positioning (UroTreND Study)
Published in Methods and protocols (01-04-2024)“…In addition to general anesthesia and mechanical ventilation, robotic-assisted laparoscopic radical prostatectomy (RALP) necessitates maintaining a…”
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Oxidative burst and Dectin-1-triggered phagocytosis affected by norepinephrine and endocannabinoids: implications for fungal clearance under stress
Published in International immunology (08-03-2018)“…Norepinephrine and a cannabinoid can modify leukocyte responses to fungi Abstract A prolonged stress burden is known to hamper the efficiency of both the…”
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Stress Related Shift Toward Inflammaging in Cosmonauts After Long-Duration Space Flight
Published in Frontiers in physiology (19-02-2019)“…Space flight exerts a specific conglomerate of stressors on humans that can modulate the immune system. The mechanism remains to be elucidated and the…”
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How do gravity alterations affect animal and human systems at a cellular/tissue level?
Published in NPJ microgravity (21-10-2023)“…The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that…”
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How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?
Published in NPJ microgravity (01-05-2024)“…Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community…”
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How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?
Published in NPJ microgravity (10-02-2024)“…Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in…”
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Exploratory RNA-seq analysis in healthy subjects reveals vulnerability to viral infections during a 12- month period of isolation and confinement
Published in Brain, behavior, & immunity. Health (01-12-2020)“…Exposure to stressful environments weakens immunity evidenced by a detectable reactivation of dormant viruses. The mechanism behind this observation remains…”
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Changes in Blood Biomarkers of Brain Injury and Degeneration Following Long-Duration Spaceflight
Published in JAMA neurology (01-12-2021)Get more information
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Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice
Published in Blood (24-10-2019)“…Fluid shear stress in the vasculature is the driving force for natural bypass growth, a fundamental endogenous mechanism to counteract the detrimental…”
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The stressed vascular barrier and coagulation - The impact of key glycocalyx components on in vitro clot formation
Published in Thrombosis research (01-02-2020)“…A functional vascular barrier controlling leukocyte recruitment into the perivascular space relies on an intact endothelial glycocalyx (EGX). Critical disease…”
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Estimating hemodynamic shear stress in murine peripheral collateral arteries by two-photon line scanning
Published in Molecular and cellular biochemistry (01-03-2019)“…Changes in wall shear stress of blood vessels are assumed to be an important component of many physiological and pathophysiological processes. However, due to…”
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Gravity-Related Immunological Changes in Human Whole Blood Cultured Under Simulated Microgravity Using an In Vitro Cytokine Release Assay
Published in Journal of interferon & cytokine research (01-12-2017)“…Although immune dysfunction by space conditions has been reported postflight, as well as during ground-based experiments, the cause(s) and nature of the…”
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Plasticity of the human IgM repertoire in response to long-term spaceflight: Running title: Diversity of cosmonaut IgM repertoire
Published in The FASEB journal (01-12-2020)“…Immune dysregulation is among the main adverse outcomes of spaceflight. Despite the crucial role of the antibody repertoire in host protection, the effects of…”
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