A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne

Abstract Introduction: Acne has a significant negative impact on quality of life (QoL): lack of self-confidence, depressive symptoms and suicidal thoughts. The objective was to assess the impact of an initial and continued therapy in severe acne patients through patient-related outcomes (PRO). Metho...

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Bibliographic Details
Published in:	The Journal of dermatological treatment Vol. 23; no. 1; pp. 26 - 34
Main Authors:	Brodell, Robert T., Schlosser, Bethanee J., Rafal, Elyse, Toth, Darryl, Tyring, Stephen, Wertheimer, Albert, Kerrouche, Nabil, Bucher, Delphine
Format:	Journal Article
Language:	English
Published:	Oslo Informa Healthcare USA on behalf of Informa UK Ltd 01-02-2012 Taylor & Francis
Subjects:	Acne Vulgaris - drug therapy Acne Vulgaris - psychology Acne-QoL Adapalene Adolescent Adult Benzoyl Peroxide - administration & dosage Benzoyl Peroxide - therapeutic use Biological and medical sciences Child Dermatologic Agents - administration & dosage Dermatologic Agents - therapeutic use Dermatology Double-Blind Method Drug Combinations Female Humans Male Medical sciences Naphthalenes - administration & dosage Naphthalenes - therapeutic use Patient Satisfaction patient satisfaction questionnaire patient-related outcomes Pharmacology. Drug treatments Quality of Life - psychology Severity of Illness Index Skin involvement in other diseases. Miscellaneous. General aspects Skin, nail, hair, dermoskeleton Young Adult Performance evaluation Human Drug Skin disease Prognosis Questionnaire patient-related outcomes Adapalene Acne Treatment efficiency Retinoid Satisfaction Pharmacotherapy patient satisfaction questionnaire Quality of life Improvement Randomization Treatment Acne-QoL Double blind study Antiacneic agent Early Severe
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Summary:	Abstract Introduction: Acne has a significant negative impact on quality of life (QoL): lack of self-confidence, depressive symptoms and suicidal thoughts. The objective was to assess the impact of an initial and continued therapy in severe acne patients through patient-related outcomes (PRO). Methods: In two sequential double-blind randomized studies, patients received either adapalene 0.1% and benzoyl peroxide 2.5% (A-BPO) or vehicle, associated with doxycycline 100 mg for 12 weeks. Patients having obtained at least a good improvement according to investigator global assessment were re-randomized for a 24-week therapy with A-BPO or vehicle. PROs were assessed using the Acne-QoL and a patient treatment satisfaction questionnaire. Results: QoL was improved at week 12 in all domains with a significant difference for the Acne-symptoms domain (p < 0.001) in favor of the A-BPO regimen. Additional 24-week A-BPO treatment showed a sustained improvement, significant (p < 0.001) for all domains except for Acne-symptoms. In the vehicle arm, QoL significantly worsened for all domains (p < 0.03). At weeks 12 and 36, a significantly higher proportion of patients receiving A-BPO vs. vehicle reported high satisfaction for five out of six treatment satisfaction items. Conclusions: The early and sustained improvement of these PROs is correlated to the fast onset of action of A-BPO, the treatment effectiveness and a good safety profile.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-News-2 ObjectType-Feature-3 content type line 23
ISSN:	0954-6634 1471-1753
DOI:	10.3109/09546634.2011.643221