Search Results - "Buchanan, Lane"
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Comparison between a deep-learning and a pixel-based approach for the automated quantification of HIV target cells in foreskin tissue
Published in Scientific reports (23-01-2024)“…The availability of target cells expressing the HIV receptors CD4 and CCR5 in genital tissue is a critical determinant of HIV susceptibility during sexual…”
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Soluble E‐cadherin: A marker of genital epithelial disruption
Published in American journal of reproductive immunology (1989) (01-03-2023)“…Problem The genital epithelial barrier is a crucial first line of defence against HIV, and epithelial disruption may enhance HIV susceptibility. Assessment of…”
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Quantitative Immunofluorescent Imaging of Immune Cells in Mucosal Tissues
Published in Methods in molecular biology (Clifton, N.J.) (2022)“…Understanding the interplay between commensals, pathogens, and immune cells in the skin and mucosal tissues is critical to improve prevention and treatment of…”
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Penile bacteria associated with HIV seroconversion, inflammation, and immune cells
Published in JCI insight (22-04-2021)“…The foreskin is a site of heterosexual acquisition of HIV-1 among uncircumcised men. However, some men remain HIV-negative despite repeated, unprotected…”
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Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial
Published in Cell reports. Medicine (17-09-2024)“…Within the penile microbiome, bacteria associated with seroconversion, immunology, and cells (BASIC species) enhance HIV susceptibility in heterosexual…”
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Incorporating Tantalum Oxide Nanoparticles into Implantable Polymeric Biomedical Devices for Radiological Monitoring
Published in Advanced healthcare materials (01-07-2023)“…Longitudinal radiological monitoring of biomedical devices is increasingly important, driven by the risk of device failure following implantation. Polymeric…”
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