Search Results - "Buchan, Sarah L."

Distinct motifs in the intracellular domain of human CD30 differentially activate canonical and alternative transcription factor NF-κB signaling by Buchan, Sarah L, Al-Shamkhani, Aymen

“…The TNF-receptor superfamily member CD30 is expressed on normal and malignant lymphocytes, including anaplastic large cell lymphoma (ALCL) cells. CD30…”
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Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc by Dadas, Osman, Allen, Joel D, Buchan, Sarah L, Kim, Jinny, Chan, H T Claude, Mockridge, C Ian, Duriez, Patrick J, Rogel, Anne, Crispin, Max, Al-Shamkhani, Aymen

“…T cell expressed CD27 provides costimulation upon binding to inducible membrane expressed trimeric CD70 and is required for protective CD8 T cell responses…”
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CTLA-4: Checkpoints beyond the membrane by Buchan, Sarah L

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The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy by Buchan, Sarah L., Rogel, Anne, Al-Shamkhani, Aymen

“…In recent years, monoclonal antibodies (mAbs) able to reinvigorate antitumor T-cell immunity have heralded a paradigm shift in cancer treatment. The most high…”
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Fcγ receptor-mediated cross-linking codefines the immunostimulatory activity of anti-human CD96 antibodies by Rogel, Anne, Ibrahim, Fathima M, Thirdborough, Stephen M, Renart-Depontieu, Florence, Birts, Charles N, Buchan, Sarah L, Preville, Xavier, King, Emma V, Al-Shamkhani, Aymen

“…New strategies that augment T cell responses are required to broaden the therapeutic arsenal against cancer. CD96, TIGIT, and CD226 are receptors that bind to…”
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DNA Vaccines to Attack Cancer by Stevenson, Freda K., Ottensmeier, Christian H., Johnson, Peter, Zhu, Delin, Buchan, Sarah L., McCann, Katy J., Roddick, Joanne S., King, Andrew T., McNicholl, Feargal, Savelyeva, Natalia, Rice, Jason

“…Delivery of antigens by injection of the encoding DNA allows access to multiple antigen-presenting pathways. Knowledge of immunological processes can therefore…”
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PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8 + T-Cell-Driven Antitumor Immunity by Buchan, Sarah L, Fallatah, Mohannad, Thirdborough, Stephen M, Taraban, Vadim Y, Rogel, Anne, Thomas, Lawrence J, Penfold, Christine A, He, Li-Zhen, Curran, Michael A, Keler, Tibor, Al-Shamkhani, Aymen

“…PD-1 checkpoint blockade has revolutionized the field of cancer immunotherapy, yet the frequency of responding patients is limited by inadequate T-cell priming…”
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Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function by Buchan, Sarah L., Dou, Lang, Remer, Marcus, Booth, Steven G., Dunn, Stuart N., Lai, Chester, Semmrich, Monika, Teige, Ingrid, Mårtensson, Linda, Penfold, Christine A., Chan, H.T. Claude, Willoughby, Jane E., Mockridge, C. Ian, Dahal, Lekh N., Cleary, Kirstie L.S., James, Sonya, Rogel, Anne, Kannisto, Päivi, Jernetz, Mats, Williams, Emily L., Healy, Eugene, Verbeek, J. Sjef, Johnson, Peter W.M., Frendéus, Björn, Cragg, Mark S., Glennie, Martin J., Gray, Juliet C., Al-Shamkhani, Aymen, Beers, Stephen A.

“…The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and…”
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DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire by Rice, Jason, Dossett, Michelle L, Öhlén, Claes, Buchan, Sarah L, Kendall, Timothy J, Dunn, Stuart N, Stevenson, Freda K, Greenberg, Philip D

“…The majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must…”
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Akt signaling is critical for memory CD8⁺ T-cell development and tumor immune surveillance by Rogel, Anne, Willoughby, Jane E., Buchan, Sarah L., Leonard, Henry J., Thirdborough, Stephen M., Al-Shamkhani, Aymen

“…Memory CD8⁺ T cells confer long-term immunity against tumors, and anticancer vaccines therefore should maximize their generation. Multiple memory CD8⁺ T-cell…”
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OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence by Buchan, Sarah, Manzo, Teresa, Flutter, Barry, Rogel, Anne, Edwards, Noha, Zhang, Lei, Sivakumaran, Shivajanani, Ghorashian, Sara, Carpenter, Ben, Bennett, Clare, Freeman, Gordon J, Sykes, Megan, Croft, Michael, Al-Shamkhani, Aymen, Chakraverty, Ronjon

“…Exhaustion of chronically stimulated CD8(+) T cells is a significant obstacle to immune control of chronic infections or tumors. Although coinhibitory…”
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Differential impact of CD27 and 4-1BB costimulation on effector and memory CD8 T cell generation following peptide immunization by Willoughby, Jane E, Kerr, Jonathan P, Rogel, Anne, Taraban, Vadim Y, Buchan, Sarah L, Johnson, Peter W M, Al-Shamkhani, Aymen

“…The factors that determine differentiation of naive CD8 T cells into memory cells are not well understood. A greater understanding of how memory cells are…”
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Triggering of TNFRSF25 promotes CD8+ T‐cell responses and anti‐tumor immunity by Slebioda, Tomasz J., Rowley, Tania F., Ferdinand, John R., Willoughby, Jane E., Buchan, Sarah L., Taraban, Vadim Y., Al‐Shamkhani, Aymen

“…TNFRSF25 is a member of the TNF receptor superfamily (TNFRSF) that binds to the TNF‐like protein TL1A. Although recent studies have demonstrated a role for…”
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Death receptor 3 is essential for generating optimal protective CD41 T‐cell immunity against Salmonella by Buchan, Sarah L., Taraban, Vadim Y., Slebioda, Tomasz J., James, Sonya, Cunningham, Adam F., Al‐Shamkhani, Aymen

“…The TNF receptor superfamily member death receptor 3 (DR3) exacerbates Th2‐ and Th17‐cell‐mediated inflammatory and autoimmune conditions, yet no role in host…”
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CD27 costimulation contributes substantially to the expansion of functional memory CD8+ T cells after peptide immunization by Taraban, Vadim Y., Rowley, Tania F., Kerr, Jonathan P., Willoughby, Jane E., Johnson, Peter M. W., Al‐Shamkhani, Aymen, Buchan, Sarah L.

“…Naive T cells require signals from multiple costimulatory receptors to acquire full effector function and differentiate to long‐lived memory cells. The…”
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Death receptor 3 is essential for generating optimal protective CD4⁺ T-cell immunity against Salmonella by Buchan, Sarah L, Taraban, Vadim Y, Slebioda, Tomasz J, James, Sonya, Cunningham, Adam F, Al-Shamkhani, Aymen

“…The TNF receptor superfamily member death receptor 3 (DR3) exacerbates Th2- and Th17-cell-mediated inflammatory and autoimmune conditions, yet no role in host…”
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DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance by Chaise, Coralie, Buchan, Sarah L., Rice, Jason, Marquet, Jeanine, Rouard, Hélène, Kuentz, Mathieu, Vittes, Gisella E., Molinier-Frenkel, Valérie, Farcet, Jean-Pierre, Stauss, Hans J., Delfau-Larue, Marie-Hélène, Stevenson, Freda K.

“…The Wilms tumor antigen, WT1, is associated with several human cancers, including leukemia. We evaluated WT1 as an immunotherapeutic target using our proven…”
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DNA fusion vaccines induce epitope-specific cytotoxic CD8+ T cells against human leukemia-associated minor histocompatibility antigens by RICE, Jason, DUNN, Stuart, PIPER, Karen, BUCHAN, Sarah L, MOSS, Paul A, STEVENSON, Freda K

“…The graft-versus-leukemia effect of allogeneic stem-cell transplantation is believed to be mediated by T-cell recognition of minor histocompatibility antigens…”
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Distinct Motifs in the Intracellular Domain of Human CD30 Differentially Activate Canonical and Alternative Transcription Factor NF-[kappa]B Signaling by Buchan, Sarah L, Al-Shamkhani, Aymen

“…The TNF-receptor superfamily member CD30 is expressed on normal and malignant lymphocytes, including anaplastic large cell lymphoma (ALCL) cells. CD30…”
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PD-1 blockade and CD27 stimulation activate distinct transcriptional programs that synergize for CD8+ T-cell driven anti-tumor immunity by Buchan, Sarah L., Fallatah, Mohannad, Thirdborough, Stephen M., Taraban, Vadim Y., Rogel, Anne, Thomas, Lawrence J., Penfold, Christine A., He, Li-Zhen, Curran, Michael A., Keler, Tibor, Al-Shamkhani, Aymen

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