Search Results - "Buchan, J Ross"

mRNP granules: Assembly, function, and connections with disease by Buchan, J Ross

“…Messenger ribonucleoprotein (mRNP) granules are dynamic, self-assembling structures that harbor non-translating mRNAs bound by various proteins that regulate…”
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Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer by Liu, Guangbo, Pei, Fen, Yang, Fengqing, Li, Lingxiao, Amin, Amit Dipak, Liu, Songnian, Buchan, J Ross, Cho, William C

“…Non-small-cell lung cancer (NSCLC) constitutes 85% of all lung cancers, and is the leading cause of cancer-related death worldwide. The poor prognosis and…”
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Eukaryotic Stress Granules: The Ins and Outs of Translation by Buchan, J. Ross, Parker, Roy

“…The stress response in eukaryotic cells often inhibits translation initiation and leads to the formation of cytoplasmic RNA-protein complexes referred to as…”
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Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function by Buchan, J. Ross, Kolaitis, Regina-Maria, Taylor, J. Paul, Parker, Roy

“…Stress granules and P bodies are conserved cytoplasmic aggregates of nontranslating messenger ribonucleoprotein complexes (mRNPs) implicated in the regulation…”
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P bodies promote stress granule assembly in Saccharomyces cerevisiae by Buchan, J. Ross, Muhlrad, Denise, Parker, Roy

“…Recent results indicate that nontranslating mRNAs in eukaryotic cells exist in distinct biochemical states that accumulate in P bodies and stress granules,…”
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Endocytosis regulates TDP-43 toxicity and turnover by Liu, Guangbo, Coyne, Alyssa N., Pei, Fen, Vaughan, Spencer, Chaung, Matthew, Zarnescu, Daniela C., Buchan, J. Ross

“…Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. ALS-affected motor neurons exhibit aberrant localization of a nuclear RNA…”
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HARLEY mitigates user bias and facilitates efficient quantification and co-localization analyses of foci in yeast fluorescence images by Shabanov, Ilya, Buchan, J. Ross

“…Quantification of cellular structures in fluorescence microscopy data is a key means of understanding cellular function. Unfortunately, numerous cellular…”
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Stress-specific composition, assembly and kinetics of stress granules in Saccharomyces cerevisiae by Buchan, J. Ross, Yoon, Je-Hyun, Parker, Roy

“…Eukaryotic cells respond to cellular stresses by the inhibition of translation and the accumulation of mRNAs in cytoplasmic RNA-protein (ribonucleoprotein)…”
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Cdc48/VCP and Endocytosis Regulate TDP-43 and FUS Toxicity and Turnover by Liu, Guangbo, Byrd, Aaron, Warner, Amanda N., Pei, Fen, Basha, Eman, Buchanan, Allison, Buchan, J. Ross

“…Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. TDP-43 (TAR DNA-binding protein 43) and FUS (fused in sarcoma) are…”
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Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation by Fernandes, Nikita, Nero, Luke, Lyons, Shawn M, Ivanov, Pavel, Mittelmeier, Telsa M, Bolger, Timothy A, Buchan, J Ross

“…Stress granules (SGs) are hypothesized to facilitate TAR DNA-binding protein 43 (TDP-43) cytoplasmic mislocalization and aggregation, which may underly…”
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RNAs as Regulators of Cellular Matchmaking by Fernandes, Nikita, Buchan, J Ross

“…RNA molecules are increasingly being identified as facilitating or impeding the interaction of proteins and nucleic acids, serving as so-called scaffolds or…”
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High-throughput transformation of Saccharomyces cerevisiae using liquid handling robots by Liu, Guangbo, Lanham, Clayton, Buchan, J Ross, Kaplan, Matthew E

“…Saccharomyces cerevisiae (budding yeast) is a powerful eukaryotic model organism ideally suited to high-throughput genetic analyses, which time and again has…”
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EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics by Bearss, Jeremiah J, Padi, Sathish KR, Singh, Neha, Cardo-Vila, Marina, Song, Jin H, Mouneimne, Ghassan, Fernandes, Nikita, Li, Yang, Harter, Matthew R, Gard, Jaime MC, Cress, Anne E, Peti, Wolfgang, Nelson, Andrew DL, Buchan, J Ross, Kraft, Andrew S, Okumura, Koichi

“…Regulation of mRNA stability and translation plays a critical role in determining protein abundance within cells. Processing bodies (P-bodies) are critical…”
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Halting a cellular production line: responses to ribosomal pausing during translation by Buchan, J. Ross, Stansfield, Ian

“…Cellular protein synthesis is a complex polymerization process carried out by multiple ribosomes translating individual mRNAs. The process must be responsive…”
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Stress granule and P-body clearance: Seeking coherence in acts of disappearance by Buchan, J. Ross

“…Stress granules and P-bodies are conserved cytoplasmic biomolecular condensates whose assembly and composition are well documented, but whose clearance…”
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Stress granules and P-bodies – New ideas and experimental models worth exploring by Buchan, J. Ross

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Correction: Fernandes et al. Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation. Biomolecules 2020, 10 , 1367 by Fernandes, Nikita, Nero, Luke, Lyons, Shawn M, Ivanov, Pavel, Mittelmeier, Telsa M, Bolger, Timothy A, Buchan, J Ross

“…In the original article [...]…”
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tRNA properties help shape codon pair preferences in open reading frames by Buchan, J. Ross, Aucott, Lorna S., Stansfield, Ian

“…Translation elongation is an accurate and rapid process, dependent upon efficient juxtaposition of tRNAs in the ribosomal A- and P-sites. Here, we sought…”
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TOR-tured Yeast Find a New Way to Stand the Heat by Buchan, J. Ross, Capaldi, Andrew P., Parker, Roy

“…In this issue, Takahara and Maeda (2012) discover that together, Pbp1 and sequestration of the TORC1 complex in cytoplasmic mRNP stress granules provides a…”
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RPS28B mRNA acts as a scaffold promoting cis-translational interaction of proteins driving P-body assembly by Fernandes, Nikita, Buchan, J Ross

“…Abstract P-bodies (PBs) are cytoplasmic mRNA-protein (mRNP) granules conserved throughout eukaryotes which are implicated in the repression, storage and…”
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