Search Results - "Bucha, E"

Ecarin chromogenic assay--a new method for quantitative determination of direct thrombin inhibitors like hirudin by Lange, U, Nowak, G, Bucha, E

“…A new sensitive and precise method for quantitative determination of direct thrombin inhibitors is described, the ecarin chromogenic assay (ECA). Ecarin is…”
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The use of PEG-Hirudin in chronic hemodialysis monitored by the Ecarin Clotting Time: influence on clotting of the extracorporeal system and hemostatic parameters by Ulbricht, K, Bucha, E, Pöschel, K A, Stein, G, Wolf, G, Nowak, G

“…The aim of our study was to investigate the use of polyethylene glycol (PEG)-Hirudin (PEG-H) as an anticoagulant in hemodialysis including drug monitoring with…”
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Pharmacology of r-hirudin in renal impairment by Nowak, G, Bucha, E, Gööck, T, Thieler, H, Markwardt, F

“…The pharmacokinetic properties of r-hirudin were studied in nine patients suffering from different degrees of renal insufficiency. To this end, r-hirudin was…”
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Sites of elimination and pharmacokinetics of recombinant [131I]lepirudin in baboons by Meiring, S M, Lötter, M G, Badenhorst, P N, Bucha, E, Nowak, G, Kotzé, H F

“…Lepirudin has a short half-life, and only 50-60% of the intravenously administered dose is excreted by the kidneys. The fate of the remainder is unknown. We…”
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Hirudin in haemodialysis by Bucha, E, Markwardt, F, Nowak, G

“…The usability of recombinant hirudin as anticoagulant agent in haemodialysis was studied in nephrectomized dogs. To this end, we examined the capability of…”
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Hirudin as anticoagulant in experimental hemodialysis by Markwardt, F, Nowak, G, Bucha, E

“…After genetically engineered recombinant DNA desulfatohirudin (r-hirudin) had been investigated as to its pharmacokinetic behavior and blood level course in…”
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Quantitative determination of hirudin in blood and body fluids by Nowak, G, Bucha, E

“…Recent clinical studies using hirudin as anticoagulant have demonstrated that an efficient method to determine the current blood level of hirudin is imperative…”
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Prevention of experimental coronary thrombosis by hirudin by Bucha, E, Nowak, G, Markwardt, F

“…The antithrombotic activity of hirudin was studied in a rat coronary thrombosis model. The thrombus formation was induced by external application of silver…”
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Is platelet adhesion assay able to quantify drug-induced platelet dysfunction? by Schumann, Alrun, Bucha, Elke, Nowak, Götz

“…The platelet adhesion assay (PADA) is an innovative method for the detection of both normal, pathologically increased or decreased platelet adhesiveness…”
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Determination of direct thrombin inhibitors like hirudin in plasma - Comparison of the Ecarin Chromogenic Assay (ECA) with the Ecarin Clotting Time (ECT) and the Activated Partial Thromboplastin Time (APTT) by Lange, U., Olschewski, A., Heider, A., Nowak, G., Bucha, E.

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Anticoagulant efficacy of PEG-Hirudin in patients on maintenance hemodialysis by Pöschel, Katrin Annett, Bucha, Elke, Esslinger, Hans-ulrich, Ulbricht, Kristina, Nörtersheuser, Peter, Stein, Günter, Nowak, Götz

“…Anticoagulant efficacy of PEG-Hirudin in patients on maintenance hemodialysis. Heparins are currently the anticoagulants of choice in long-term hemodialysis…”
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In vitro study of r-hirudin permeability through membranes of different haemodialysers by Bucha, Elke, Kreml, Reiner, Nowak, Goetz

“…Background. After introducing the specific thrombin inhibitor recombinant hirudin (r-hirudin) into clinical practice in cases of heparin-induced…”
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Ecarin chromogenic assay: an innovative test for quantitative determination of direct thrombin inhibitors in plasma by Lange, U, Olschewski, A, Nowak, G, Bucha, E

“…The ecarin chromogenic assay (ECA) was developed for quantitative determination of direct thrombin inhibitors. As a further development of the ecarin clotting…”
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Platelet Adhesion Assay (PADA), a new quantitative test for assessment of platelet function and therapeutic drug monitoring of GPIIb/IIIa and ADP receptor antagonists by Schumann, A, Wiesenburg, A, Bucha, E, Nowak, G

“…Platelet ADhesion Assay (PADA) is a POCT capable method for quantitative determination of platelet adhesiveness. Using special polymer particles and test…”
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Anticoagulation with r-hirudin in regular haemodialysis with heparin-induced thrombocytopenia (HIT II). The first long-term application of r-hirudin in a haemodialysis patient by Nowak, G, Bucha, E, Brauns, I, Czerwinski, R

“…A 69-year-old female patient with renal failure developed heparin-induced thrombocytopenia type II (HIT II) two months after starting haemodialysis therapy…”
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Favourable effect of defibrotide in lipid A-induced shock in pigs by Hohlfeld, T, Bucha, E, Nowak, G, Brüggener, E, Strobach, H, Schrör, K

“…Defibrotide (DEF), a compound previously found to stimulate vascular prostacyclin (PGI2) formation, has been investigated in an experimental model of septic…”
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Pharmacodynamics and pharmacokinetics of polyethylene glycol-hirudin in patients with chronic renal failure by Pöschel, Katrin Annett, Bucha, Elke, Esslinger, Hans-U, Nörtersheuser, Peter, Jansa, Ute, Schindler, Sabine, Nowak, Götz, Stein, Günter

“…Pharmacodynamics and pharmacokinetics of polyethylene glycol-hirudin in patients with chronic renal failure. Hirudin selectively inhibits thrombin without…”
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Prothrombin conversion intermediate effectively neutralizes toxic levels of hirudin by Nowak, Götz, Bucha, Elke

“…Meizothrombin, the stable intermediate product of ecarin-induced prothrombin conversion, was investigated for its ability to bind hirudin in blood. After in…”
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R-hirudin as anticoagulant in regular hemodialysis therapy: finding of therapeutic R-hirudin blood/plasma concentrations and respective dosages by Bucha, E, Nowak, G, Czerwinski, R, Thieler, H

“…Recently heparin-induced thrombocytopenia type II has been diagnosed more frequently and does not exclude hemodialysis patients. Up to now, recombinant hirudin…”
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Hirudin - A new anticoagulant in haemodialysis (HD) by Nowak, G., Bucha, E., Czerwinski, R., Thieler, H.

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