Search Results - "Buch, Shilpa J."

Systems biology analyses reveal enhanced chronic morphine distortion of gut-brain interrelationships in simian human immunodeficiency virus infected rhesus macaques by Olwenyi, Omalla A, Johnson, Samuel D, Bidokhti, Mehdi, Thakur, Vandana, Pandey, Kabita, Thurman, Michellie, Acharya, Arpan, Uppada, Srijayaprakash, Callen, Shannon, Giavedoni, Luis, Ranga, Udaykumar, Buch, Shilpa J, Byrareddy, Siddappa N

“…Commonly used opioids, such as morphine have been implicated in augmented SIV/HIV persistence within the central nervous system (CNS). However, the extent of…”
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Diminished Peripheral CD29hi Cytotoxic CD4+ T Cells Are Associated With Deleterious Effects During SIV Infection by Olwenyi, Omalla A, Johnson, Samuel D, Pandey, Kabita, Thurman, Michellie, Acharya, Arpan, Buch, Shilpa J, Fox, Howard S, Podany, Anthony T, Fletcher, Courtney V, Byrareddy, Siddappa N

“…Cytotoxic CD4+ T cells (CD4+ CTLs) limit HIV pathogenesis, as evidenced in elite controllers (a subset of individuals who suppress the virus without the need…”
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HIV-1 Tat co-operates with IFN-gamma and TNF-alpha to increase CXCL10 in human astrocytes by Williams, Rachel, Yao, Honghong, Dhillon, Navneet K, Buch, Shilpa J

“…HIV-associated neurological disorders (HAND) are estimated to affect 60% of the HIV infected population. HIV-encephalitis (HIVE), the pathological correlate of…”
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Chronic SIV and morphine treatment increases heat shock protein 5 expression at the synapse by Pendyala, Gurudutt, Periyasamy, Palsamy, Callen, Shannon, Fox, Howard S., Lisco, Steven J., Buch, Shilpa J.

“…The abuse of opiates such as morphine in synergy with HIV infection accelerates neurocognitive impairments and neuropathology in the CNS of HIV-infected…”
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Cannabinoid Receptor 2 Activation: A Means to Prevent Monocyte–Endothelium Engagement by Buch, Shilpa J.

“…This Commentary highlights the article by Rom et al which shows that selective cannabinoid receptor 2 activation in leukocytes decreases key steps in…”
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Chronic Morphine Administration Differentially Modulates Viral Reservoirs in a Simian Immunodeficiency Virus SIVmac251-Infected Rhesus Macaque Model by Acharya, Arpan, Olwenyi, Omalla A, Thurman, Michellie, Pandey, Kabita, Morsey, Brenda M, Lamberty, Benjamin, Ferguson, Natasha, Callen, Shannon, Fang, Qiu, Buch, Shilpa J, Fox, Howard S, Byrareddy, Siddappa N

“…Human immunodeficiency virus (HIV) persists in cellular reservoirs despite effective combined antiretroviral therapy (cART), and there is viremia flare-up upon…”
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Cannabinoid Receptor 2 Activation by Buch, Shilpa J

“…This Commentary highlights the article by Rom et al which shows that selective cannabinoid receptor 2 activation in leukocytes decreases key steps in…”
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A Coat of Many Colors: Neuroimmune Crosstalk in Human Immunodeficiency Virus Infection by Kraft-Terry, Stephanie D., Buch, Shilpa J., Fox, Howard S., Gendelman, Howard E.

“…The use of antiretroviral therapy has reduced mortality and increased the quality of life of HIV-1-infected people, particularly in more developed countries…”
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HIV‐1 Nef hijacks both exocytic and endocytic pathways of host intracellular trafficking through differential regulation of Rab GTPases by Kumari, Sushila, Dash, Prasanta K., Kumari, Tripti, Guo, Ming‐Lei, Ghosh, Jimut Kanti, Buch, Shilpa J., Tripathi, Raj Kamal

“…Background HIV‐1 Nef regulates several cellular functions in an infected cell which results in viral persistence and AIDS pathogenesis. The currently…”
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Reactive Oxygen Species/Hypoxia-Inducible Factor-1α/Platelet-Derived Growth Factor-BB Autocrine Loop Contributes to Cocaine-Mediated Alveolar Epithelial Barrier Damage by Yang, Lu, Chen, Xufeng, Simet, Samantha M, Hu, Guoku, Cai, Yu, Niu, Fang, Kook, Yeonhee, Buch, Shilpa J

“…Abuse of psychostimulants, such as cocaine, has been shown to be closely associated with complications of the lung, such as pulmonary hypertension, edema,…”
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HIV-1 transgenic rats display mitochondrial abnormalities consistent with abnormal energy generation and distribution by Villeneuve, Lance M., Purnell, Phillip R., Stauch, Kelly L., Callen, Shannon E., Buch, Shilpa J., Fox, Howard S.

“…With the advent of the combination antiretroviral therapy era (cART), the development of AIDS has been largely limited in the USA. Unfortunately, despite the…”
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HIV Neuropathogenesis: a Tight Rope Walk of Innate Immunity by Yao, Honghong, Bethel-Brown, Crystal, Li, Cicy Zidong, Buch, Shilpa J.

“…During the course of HIV-1 disease, virus neuroinvasion occurs as an early event, within weeks following infection. Intriguingly, subsequent central nervous…”
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Proinflammatory cytokines and HIV-1 synergistically enhance CXCL10 expression in human astrocytes by Williams, Rachel, Dhillon, Navneet K., Hegde, Sonia T., Yao, Honghong, Peng, Fuwang, Callen, Shannon, Chebloune, Yahia, Davis, Randall L., Buch, Shilpa J.

“…HIV encephalitis (HIVE), the pathologic correlate of HIV‐associated dementia (HAD) is characterized by astrogliosis, cytokine/chemokine dysregulation, and…”
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Neuroimmune Pharmacology as an Emerging Curriculum for Pre-Medical Students by Buch, Shilpa J.

“…As science continues to evolve and expand some major areas of interest are now crossing boundaries to become multi-disciplinary in nature closely reflecting…”
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Effects of Morphine on Behavioral Task Performance in SIV-Infected Rhesus Macaques by Marcario, Joanne K., Pendyala, Gurudutt, Riazi, Mariam, Fleming, Kandace, Marquis, Janet, Callen, Shannon, Lisco, Steven J., Fowler, Stephen C., Cheney, Paul D., Buch, Shilpa J.

“…The abuse of opiates such as morphine in synergy with HIV infection not only exacerbates neuropathogenesis but significantly impacts behavioral attributes in…”
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Morphine enhances Tat-induced activation in murine microglia by Bokhari, Sirosh M, Yao, Honghong, Bethel-Brown, Crystal, Fuwang, Peng, Williams, Rachel, Dhillon, Navneet K, Hegde, Ramakrishna, Kumar, Anil, Buch, Shilpa J

“…There is increasing evidence that opiates accelerate the pathogenesis and progression of acquired immunodeficiency syndrome (AIDS), as well as the incidence of…”
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HIV-1 Tat-Mediated Neurotoxicity in Retinal Cells by Chatterjee, Nivedita, Callen, Shannon, Seigel, Gail M., Buch, Shilpa J.

“…The current study was aimed at investigating the effect of HIV-1 protein Tat on the retinal neurosensory cell line R28. Exposure of Tat resulted in induction…”
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Cocaine-mediated Alteration in Tight Junction Protein Expression and Modulation of CCL2/CCR2 Axis Across the Blood-Brain Barrier: Implications for HIV-Dementia by Dhillon, Navneet K., Peng, Fuwang, Bokhari, Sirosh, Callen, Shannon, Shin, Sun-Hye, Zhu, Xuhui, Kim, Kee-Jun, Buch, Shilpa J.

“…One of the hallmark features underlying the pathogenesis of HIV encephalitis is the disruption of blood–brain barrier (BBB). Cocaine, often abused by…”
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Cocaine-mediated enhancement of virus replication in macrophages: Implications for human immunodeficiency virus-associated dementia by Dhillon, Navneet K, Williams, Rachel, Peng, Fuwang, Tsai, Yi-jou, Dhillon, Sukhbir, Nicolay, Brandon, Gadgil, Milind, Kumar, Anil, Buch, Shilpa J

“…Injection drug use has been recognized as a major risk factor for acquired immunodeficiency syndrome (AIDS) from the outset of the epidemic. Cocaine, one of…”
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Chronic morphine exposure causes pronounced virus replication in cerebral compartment and accelerated onset of AIDS in SIV/SHIV-infected Indian rhesus macaques by Kumar, Rakesh, Orsoni, Suheydi, Norman, Lisa, Verma, Ashish S., Tirado, Grissell, Giavedoni, Luis D., Staprans, Silvija, Miller, Gregory M., Buch, Shilpa J., Kumar, Anil

“…Six morphine-exposed and 3 control male Indian rhesus macaques were intravenously inoculated with mixture of SHIV KU, SHIV 89.6P and SIV/17E-Fr. These animals…”
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