Search Results - "Bucakci, Akin"

Microhomologies are prevalent at Cas9-induced larger deletions by Owens, Dominic D G, Caulder, Adam, Frontera, Vincent, Harman, Joe R, Allan, Alasdair J, Bucakci, Akin, Greder, Lucas, Codner, Gemma F, Hublitz, Philip, McHugh, Peter J, Teboul, Lydia, de Bruijn, Marella F T R

“…Abstract The CRISPR system is widely used in genome editing for biomedical research. Here, using either dual paired Cas9D10A nickases or paired Cas9 nuclease…”
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Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development by Owens, Dominic D. G., Anselmi, Giorgio, Oudelaar, A. Marieke, Downes, Damien J., Cavallo, Alessandro, Harman, Joe R., Schwessinger, Ron, Bucakci, Akin, Greder, Lucas, de Ornellas, Sara, Jeziorska, Danuta, Telenius, Jelena, Hughes, Jim R., de Bruijn, Marella F. T. R.

“…The transcription factor RUNX1 is a critical regulator of developmental hematopoiesis and is frequently disrupted in leukemia. Runx1 is a large, complex gene…”
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3126 – PERSISTENT METABOLIC DEFLATION OF HEMATOPOIETIC STEM CELLS (HSCS) AFTER CHEMOTHERAPY CAUSES PREMATURE HEMATOPOIETIC AGEING by Mansell, Els, van Tienhoven, Tim, Sjoberg, Julia, Lepland, Johanna, Rydstrom, Anna, Bucakci, Akin, Maaskant, Wout, Enver, Tariq, Larsson, Jonas, Raaijmakers, Marc, Sigurdsson, Valgardur

“…Hematopoietic recovery between cycles of chemotherapy is critical for treatment continuation and outcome. Hematopoietic recovery is frequently defined based on…”
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