Search Results - "Buas, Matthew F."
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Epidemiology and Risk Factors for Gastroesophageal Junction Tumors: Understanding the Rising Incidence of This Disease
Published in Seminars in radiation oncology (2013)“…Gastroesophageal (GE) junction carcinoma is a rare but often lethal condition with increasing importance as a public health problem in recent decades. Whereas…”
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Salivary metabolite profiling distinguishes patients with oral cavity squamous cell carcinoma from normal controls
Published in PloS one (20-09-2018)“…Oral cavity squamous cell carcinoma (OCC) and oropharyngeal squamous cell carcinoma (OPC) are among the most common cancers worldwide and are associated with…”
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Identification of novel candidate plasma metabolite biomarkers for distinguishing serous ovarian carcinoma and benign serous ovarian tumors
Published in Gynecologic oncology (01-01-2016)“…Abstract Objective Serous ovarian carcinoma (OC) represents a leading cause of cancer-related death among U.S. women. Non-invasive tools have recently emerged…”
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The Notch Effector Hey1 Associates with Myogenic Target Genes to Repress Myogenesis
Published in The Journal of biological chemistry (08-01-2010)“…Members of the Hey family of transcriptional repressors are basic helix-loop-helix proteins that are thought to act downstream of Notch in diverse tissues…”
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Quantitative global lipidomics analysis of patients with ovarian cancer versus benign adnexal mass
Published in Scientific reports (13-09-2021)“…Altered lipid metabolism has emerged as an important feature of ovarian cancer (OC), yet the translational potential of lipid metabolites to aid in diagnosis…”
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Inhibition of myogenesis by Notch: Evidence for multiple pathways
Published in Journal of cellular physiology (01-01-2009)“…Notch signaling is critical for skeletal muscle development and regeneration, permitting the expansion of progenitor cells by preventing premature…”
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SNP Regulation of microRNA Expression and Subsequent Colon Cancer Risk
Published in PloS one (02-12-2015)“…MicroRNAs (miRNAs) regulate messenger RNAs (mRNAs) and as such have been implicated in a variety of diseases, including cancer. MiRNAs regulate mRNAs through…”
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Genes Relevant to Tissue Response to Cancer Therapy Display Diurnal Variation in mRNA Expression in Human Oral Mucosa
Published in Journal of circadian rhythms (17-06-2021)“…To address a critical gap for application of cancer chronotherapy of when would be the best time(s) for treating an individual cancer patient, we conducted a…”
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Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett’s Esophagus
Published in American journal of human genetics (04-08-2016)“…Few gene-environment interactions (G × E) have been discovered in cancer epidemiology thus far, in part due to the large number of possible G × E to be…”
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Regulation of skeletal myogenesis by Notch
Published in Experimental cell research (01-11-2010)“…Notch signaling has emerged as a key player in skeletal muscle development and regeneration. Simply stated, Notch signaling inhibits differentiation…”
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Survival disparities among racial/ethnic groups of women with ovarian cancer: An update on data from the Surveillance, Epidemiology and End Results (SEER) registry
Published in Cancer epidemiology (01-10-2019)“…•Non-Hispanic black women have worse survival compared to non-Hispanic white women.•This survival difference is more pronounced among women diagnosed under age…”
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A risk variant for Barrett's esophagus and esophageal adenocarcinoma at chr8p23.1 affects enhancer activity and implicates multiple gene targets
Published in Human molecular genetics (28-11-2022)“…Nineteen genetic susceptibility loci for esophageal adenocarcinoma (EAC) and its precursor Barrett's esophagus (BE) have been identified through genome-wide…”
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Prioritization and functional analysis of GWAS risk loci for Barrett’s esophagus and esophageal adenocarcinoma
Published in Human molecular genetics (03-02-2022)“…Abstract Genome-wide association studies (GWAS) have identified ~20 genetic susceptibility loci for esophageal adenocarcinoma (EAC), and its precursor,…”
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Differences in microRNA expression in breast cancer between women of African and European ancestry
Published in Carcinogenesis (New York) (12-03-2019)“…A number of miRNAs were differentially expressed by tumor subtype and between races. These ER-subtype and race-related miRNAs may represent promising candidate…”
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Candidate early detection protein biomarkers for ER+/PR+ invasive ductal breast carcinoma identified using pre-clinical plasma from the WHI observational study
Published in Breast cancer research and treatment (01-09-2015)“…Estrogen receptor (ER)-positive/progesterone receptor (PR)-positive invasive ductal carcinoma accounts for ~45 % of invasive breast cancer (BC) diagnoses in…”
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FOXA1 Protein Expression in ER + and ER - Breast Cancer in Relation to Parity and Breastfeeding in Black and White Women
Published in Cancer epidemiology, biomarkers & prevention (01-02-2020)“…Forkhead box protein A1 (FOXA1) promotes luminal differentiation, and hypermethylation of the gene can be a mechanism of developing estrogen receptor-negative…”
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Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett’s esophagus, and high-grade dysplasia/esophageal adenocarcinoma
Published in Metabolomics (01-03-2017)“…Introduction/objectives Incidence of esophageal adenocarcinoma (EA), an often fatal cancer, has increased sharply over recent decades. Several important risk…”
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FOXA1 hypermethylation: link between parity and ER-negative breast cancer in African American women?
Published in Breast cancer research and treatment (01-11-2017)“…Background Reproductive factors, particularly parity, have differential effects on breast cancer risk according to estrogen receptor (ER) status, especially…”
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Targeted plasma metabolome response to variations in dietary glycemic load in a randomized, controlled, crossover feeding trial in healthy adults
Published in Food & function (01-09-2015)“…Low versus high glycemic load (GL) diet patterns are inversely associated with obesity and chronic diseases such as cancer and cardiovascular disease. These…”
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Recommendation to use exact P-values in biomarker discovery research in place of approximate P-values
Published in Cancer epidemiology (01-10-2018)“…•Normal and logit-normal approximate P-values are frequently used in biomarker studies.•Approximate P-values can lead to inappropriate biomarker selection…”
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