Search Results - "Bu, Zimei"

An ensemble of flexible conformations underlies mechanotransduction by the cadherin–catenin adhesion complex by Bush, Martin, Alhanshali, Bashir M., Stanley, Christopher B., Heller, William T., Matsui, Tsutomu, Weiss, Thomas M., Nicholl, Iain D., Walz, Thomas, Callaway, David J. E.

“…The cadherin–catenin adhesion complex is the central component of the cell–cell adhesion adherens junctions that transmit mechanical stress from cell to cell…”
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Canonical and Noncanonical Sites Determine NPT2A Binding Selectivity to NHERF1 PDZ1 by Mamonova, Tatyana, Zhang, Qiangmin, Khajeh, Jahan Ali, Bu, Zimei, Bisello, Alessandro, Friedman, Peter A

“…Na+/H+ Exchanger Regulatory Factor-1 (NHERF1) is a scaffolding protein containing 2 PDZ domains that coordinates the assembly and trafficking of transmembrane…”
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Ligand-Induced Structural Transitions in ErbB Receptor Extracellular Domains by Dawson, Jessica P., Bu, Zimei, Lemmon, Mark A.

“…Crystallographic studies showed that epidermal growth factor (EGF) receptor activation involves major domain rearrangements. Without bound ligand, the…”
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Phosphatidylinositol 4,5-Bisphosphate Clusters the Cell Adhesion Molecule CD44 and Assembles a Specific CD44-Ezrin Heterocomplex, as Revealed by Small Angle Neutron Scattering by Chen, Xiaodong, Khajeh, Jahan Ali, Ju, Jeong Ho, Gupta, Yogesh K., Stanley, Christopher B., Do, Changwoo, Heller, William T., Aggarwal, Aneel K., Callaway, David J.E., Bu, Zimei

“…The cell adhesion molecule CD44 regulates diverse cellular functions, including cell-cell and cell-matrix interaction, cell motility, migration,…”
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Activation of Nanoscale Allosteric Protein Domain Motion Revealed by Neutron Spin Echo Spectroscopy by Farago, Bela, Li, Jianquan, Cornilescu, Gabriel, Callaway, David J.E., Bu, Zimei

“…NHERF1 is a multidomain scaffolding protein that assembles signaling complexes, and regulates the cell surface expression and endocytic recycling of a variety…”
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Coupled Protein Domain Motion in Taq Polymerase Revealed by Neutron Spin-Echo Spectroscopy by Zimei Bu, Ralf Biehl, Michael Monkenbusch, Richter, Dieter, David J. E. Callaway

“…Long-range conformational changes in proteins are ubiquitous in biology for the transmission and amplification of signals; such conformational changes can be…”
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Protein Kinase C Phosphorylation Disrupts Na+/H+ Exchanger Regulatory Factor 1 Autoinhibition and Promotes Cystic Fibrosis Transmembrane Conductance Regulator Macromolecular Assembly by Li, Jianquan, Poulikakos, Poulikos I., Dai, Zhongping, Testa, Joseph R., Callaway, David J.E., Bu, Zimei

“…An emerging theme in cell signaling is that membrane-bound channels and receptors are organized into supramolecular signaling complexes for optimum function…”
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Ezrin Controls the Macromolecular Complexes Formed between an Adapter Protein Na+/H+ Exchanger Regulatory Factor and the Cystic Fibrosis Transmembrane Conductance Regulator by Li, Jianquan, Dai, Zhongping, Jana, Deirdre, Callaway, David J.E., Bu, Zimei

“…Na+/H+ exchanger regulatory factor (NHERF) is an adapter protein that is responsible for organizing a number of cell receptors and channels. NHERF contains two…”
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Solution Structure of the A4 Domain of Factor XI Sheds Light on the Mechanism of Zymogen Activation by Samuel, Dharmaraj, Cheng, Hong, Riley, Paul W., Canutescu, Adrian A., Nagaswami, Chandrasekaran, Weisel, John W., Bu, Zimei, Walsh, Peter N., Roder, Heinrich

“…Factor XI (FXI) is a homodimeric blood coagulation protein. Each monomer comprises four tandem apple-domain repeats (A1-A4) and a serine protease domain. We…”
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Phosphatidylinositol 4,5‐bisphosphate Activates the Cell Adhesion Molecule CD44 and Assembles a CD44‐Ezrin Heterotetramer Complex as Revealed by Small Angle neutron Scattering by Bu, Zimei

“…Abstract only The cell adhesion molecule CD44 regulates diverse cellular functions, including cell‐cell and cell‐matrix interaction, cell motility, migration,…”
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Structure-specific DNA-induced Conformational Changes in Taq Polymerase Revealed by Small Angle Neutron Scattering by Ho, Derek L., Byrnes, W. Malcolm, Ma, Wu-po, Shi, Yuan, Callaway, David J.E., Bu, Zimei

“…The DNA polymerase I from Thermus aquaticus (Taq polymerase) performs lagging-strand DNA synthesis and DNA repair. Taq polymerase contains a polymerase domain…”
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α-Catenin Structure and Nanoscale Dynamics in Solution and in Complex with F-Actin by Nicholl, Iain, Callaway, David, Bu, Zimei

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An ensemble of cadherin-catenin-vinculin complex employs vinculin as the major F-actin binding mode by Shi, Bright, Matsui, Tsutomu, Qian, Shuo, Weiss, Thomas M., Nicholl, Iain D., Callaway, David J.E., Bu, Zimei

“…The cell-cell adhesion cadherin-catenin complexes recruit vinculin to the adherens junction (AJ) to modulate the mechanical couplings between neighboring…”
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Nanoscale dynamics of the cadherin-catenin complex bound to vinculin revealed by neutron spin echo spectroscopy by Callaway, David J E, Nicholl, Iain D, Shi, Bright, Reyes, Gilbert, Farago, Bela, Bu, Zimei

“…We report a neutron spin echo (NSE) study of the nanoscale dynamics of the cell-cell adhesion cadherin-catenin complex bound to vinculin. Our measurements and…”
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Dynamic regimes and correlated structural dynamics in native and denatured alpha-lactalbumin 1 1Edited by M. F. Moody by Bu, Zimei, Cook, Jeremy, Callaway, David J.E

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Quantitative determination of the topological propensities of amyloidogenic peptides by Shi, Yuan, Stouten, Pieter F.W., Pillalamarri, Nirmala, Barile, Lauren, Rosal, Ramon V., Teichberg, Saul, Bu, Zimei, Callaway, David J.E.

“…One of the interesting puzzles of amyloid beta-peptide of Alzheimer's disease (Aβ) is that it appears to polymerize into amyloid fibrils in a parallel beta…”
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Activated nanoscale actin-binding domain motion in the catenin–cadherin complex revealed by neutron spin echo spectroscopy by Farago, Bela, Nicholl, Iain D., Wang, Shen, Cheng, Xiaolin, Callaway, David J. E., Bu, Zimei

“…As the core component of the adherens junction in cell–cell adhesion, the cadherin–catenin complex transduces mechanical tension between neighboring cells…”
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An ensemble of cadherin-catenin-vinculin complex employs vinculin as the major F-actin binding mode by Shi, Bright, Matsui, Tsutomu, Qian, Shuo, Weiss, Thomas M., Nicholl, Iain D., Callaway, David J.E., Bu, Zimei

“…The cell-cell adhesion cadherin-catenin complexes recruit vinculin to the adherens junction (AJ) to modulate the mechanical couplings between neighboring…”
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Nanoscale Protein Dynamics and Long-Range Allostery in Cell Signaling by Bu, Zimei, Callaway, David J.E.

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Visualizing the nanoscale: protein internal dynamics and neutron spin echo spectroscopy by Callaway, David JE, Bu, Zimei

“…[Display omitted] •Nanoscale protein dynamics affects cell signaling propagation via long-range allostery in a largely unknown fashion.•It is difficult at best…”
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