Search Results - "Bu, Yongqian"
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Haemonchus contortus HcL6 promoted the Th9 immune response in goat PBMCs by activating the STAT6/PU.1/NF-κB pathway
Published in Veterinary research (Paris) (22-09-2023)“…Th9 cells play a crucial role in parasite immunity. The development of Th9 cells is facilitated by several cytokines. Key transcription factors, such as STAT6,…”
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Haemonchus contortus excretory and secretory proteins (HcESPs) suppress functions of goat PBMCs in vitro
Published in Oncotarget (14-06-2016)“…Excretory and secretory products (ESPs) of nematode contain various proteins which are capable of inducing the instigation or depression of the host immune…”
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Immunomodulatory dynamics of excretory and secretory products on Th9 immune response during Haemonchus contortus infection in goat
Published in PLoS neglected tropical diseases (01-04-2020)“…CD4+ T cells play critical roles in mediating adaptive immunity to a variety of pathogens. Recently, new subset of CD4+T named as T helper 9 cells that express…”
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Immunization of Goats with Recombinant Protein 14-3-3 Isoform 2(rHcftt-2) Induced Moderate Protection against Haemonchus contortus Challenge
Published in Pathogens (Basel) (06-01-2020)“…A previous study identified that isoform 2 (Hcftt-2) of the 14-3-3 protein of ( ) could suppress immune functions of goat peripheral blood mononuclear cells…”
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Immunization With Recombinant Haemonchus contortus Y75B8A.8 Partially Protects Local Crossbred Female Goats From Haemonchus contortus Infection
Published in Frontiers in veterinary science (04-04-2022)“…Y75B8A.8 (Hc8) derived from excretory-secretory (ES) products was identified as a functional inhibitor of goat interleukin 2 (IL-2). It may act as a vaccine…”
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Adhesion-Regulating Molecule from Haemonchus contortus : Potential Antigen for Diagnosis of Early Infection in Goats
Published in Pathogens (Basel) (30-12-2019)“…, a blood-sucking nematode of ruminants, causes large economic losses worldwide. Diagnosis of infection mainly depends on the evaluation of clinical signs and…”
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Haemonchus contortus HcL6 promoted the Th9 immune response in goat PBMCs by activating the STAT6/PU.1/NF-κB pathway
Published in Veterinary research (Paris) (22-09-2023)“…Th9 cells play a crucial role in parasite immunity. The development of Th9 cells is facilitated by several cytokines. Key transcription factors, such as STAT6,…”
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Journal Article -
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Haemonchus contortus transthyretin domain - containing protein (HcTTR): A promising vaccine candidate against Haemonchus contortus infection
Published in Veterinary parasitology (01-03-2020)“…•Active trials with the vaccination of recombinant HcTTR demonstrated a 63.7% reduction of eggs shedding and a 66.4% reduction of worm burdens within H…”
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HcFAR, a functional inhibitor of goat TGF-β1 identified from excretory and secretory products of Haemonchus contortus
Published in Veterinary parasitology (01-10-2020)“…•HcFAR could bind to goat TGF-β1 in vitro.•rHcFAR could suppress the IgA secretion of PBMCs induced by TGF-β1.•rHcFAR could inhibit the transcription of IL-9…”
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