Search Results - "Brzózka, Krzysztof"

5'-Triphosphate RNA Is the Ligand for RIG-I by Hornung, Veit, Ellegast, Jana, Kim, Sarah, Brzózka, Krzysztof, Jung, Andreas, Kato, Hiroki, Poeck, Hendrik, Akira, Shizuo, Conzelmann, Karl-Klaus, Schlee, Martin, Endres, Stefan, Hartmann, Gunther

“…The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm of virally infected cells is largely unknown. We demonstrated…”
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Inhibition of Interferon Signaling by Rabies Virus Phosphoprotein P: Activation-Dependent Binding of STAT1 and STAT2 by BRZOZKA, Krzysztof, FINKE, Stefan, CONZELMANN, Karl-Klaus

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Identification of the Rabies Virus Alpha/Beta Interferon Antagonist: Phosphoprotein P Interferes with Phosphorylation of Interferon Regulatory Factor 3 by BRZOZKA, Krzysztof, FINKE, Stefan, CONZELMANN, Karl-Klaus

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MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma by Zhan, Yao, Guo, Jun, Yang, William, Goncalves, Christophe, Rzymski, Tomasz, Dreas, Agnieszka, Żyłkiewicz, Eliza, Mikulski, Maciej, Brzózka, Krzysztof, Golas, Aniela, Kong, Yan, Ma, Meng, Huang, Fan, Huor, Bonnie, Guo, Qianyu, da Silva, Sabrina Daniela, Torres, Jose, Cai, Yutian, Topisirovic, Ivan, Su, Jie, Bijian, Krikor, Alaoui-Jamali, Moulay A, Huang, Sidong, Journe, Fabrice, Ghanem, Ghanem E, Miller, Jr, Wilson H, Del Rincón, Sonia V

“…Melanoma can be stratified into unique subtypes based on distinct pathologies. The acral/mucosal melanoma subtype is characterized by aberrant and constitutive…”
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Inhibition of Toll-Like Receptor 7- and 9-Mediated Alpha/Beta Interferon Production in Human Plasmacytoid Dendritic Cells by Respiratory Syncytial Virus and Measles Virus by SCHLENDER, Jörg, HORNUNG, Veit, FINKE, Stefan, GÜNTHNER-BILLER, Margit, MAROZIN, Sabrina, BRZOZKA, Krzysztof, MOGHIM, Sharareh, ENDRES, Stefan, HARTMANN, Gunther, CONZELMANN, Karl-Klaus

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Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies by Szydłowski, Maciej, Garbicz, Filip, Jabłońska, Ewa, Górniak, Patryk, Komar, Dorota, Pyrzyńska, Beata, Bojarczuk, Kamil, Prochorec-Sobieszek, Monika, Szumera-Ciećkiewicz, Anna, Rymkiewicz, Grzegorz, Cybulska, Magdalena, Statkiewicz, Małgorzata, Gajewska, Marta, Mikula, Michał, Gołas, Aniela, Domagała, Joanna, Winiarska, Magdalena, Graczyk-Jarzynka, Agnieszka, Białopiotrowicz, Emilia, Polak, Anna, Barankiewicz, Joanna, Puła, Bartosz, Pawlak, Michał, Nowis, Dominika, Golab, Jakub, Tomirotti, Andrea M, Brzózka, Krzysztof, Pacheco-Blanco, Mariana, Kupcova, Kristyna, Green, Michael R, Havranek, Ondrej, Chapuy, Bjoern, Juszczyński, Przemysław

“…The family of PIM serine/threonine kinases includes three highly conserved oncogenes, and , which regulate multiple prosurvival pathways and cooperate with…”
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Tracking Fluorescence-Labeled Rabies Virus: Enhanced Green Fluorescent Protein-Tagged Phosphoprotein P Supports Virus Gene Expression and Formation of Infectious Particles by FINKE, Stefan, BRZOZKA, Krzysztof, CONZELMANN, Karl-Klaus

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Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties by Boutard, Nicolas, Białas, Arkadiusz, Sabiniarz, Aleksandra, Guzik, Paweł, Banaszak, Katarzyna, Biela, Artur, Bień, Marcin, Buda, Anna, Bugaj, Barbara, Cieluch, Ewelina, Cierpich, Anna, Dudek, Łukasz, Eggenweiler, Hans-Michael, Fogt, Joanna, Gaik, Monika, Gondela, Andrzej, Jakubiec, Krzysztof, Jurzak, Mirek, Kitlińska, Agata, Kowalczyk, Piotr, Kujawa, Maciej, Kwiecińska, Katarzyna, Leś, Marcin, Lindemann, Ralph, Maciuszek, Monika, Mikulski, Maciej, Niedziejko, Paulina, Obara, Alicja, Pawlik, Henryk, Rzymski, Tomasz, Sieprawska-Lupa, Magdalena, Sowińska, Marta, Szeremeta-Spisak, Joanna, Stachowicz, Agata, Tomczyk, Mateusz M., Wiklik, Katarzyna, Włoszczak, Łukasz, Ziemiańska, Sylwia, Zarębski, Adrian, Brzózka, Krzysztof, Nowak, Mateusz, Fabritius, Charles-Henry

“…[Display omitted] In oncology, the “Warburg effect” describes the elevated production of energy by glycolysis in cancer cells. The ubiquitous and…”
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Discovery and Structure–Activity Relationships of N‐Aryl 6‐Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors by Boutard, Nicolas, Białas, Arkadiusz, Sabiniarz, Aleksandra, Guzik, Paweł, Banaszak, Katarzyna, Biela, Artur, Bień, Marcin, Buda, Anna, Bugaj, Barbara, Cieluch, Ewelina, Cierpich, Anna, Dudek, Łukasz, Eggenweiler, Hans‐Michael, Fogt, Joanna, Gaik, Monika, Gondela, Andrzej, Jakubiec, Krzysztof, Jurzak, Mirek, Kitlińska, Agata, Kowalczyk, Piotr, Kujawa, Maciej, Kwiecińska, Katarzyna, Leś, Marcin, Lindemann, Ralph, Maciuszek, Monika, Mikulski, Maciej, Niedziejko, Paulina, Obara, Alicja, Pawlik, Henryk, Rzymski, Tomasz, Sieprawska‐Lupa, Magdalena, Sowińska, Marta, Szeremeta‐Spisak, Joanna, Stachowicz, Agata, Tomczyk, Mateusz M., Wiklik, Katarzyna, Włoszczak, Łukasz, Ziemiańska, Sylwia, Zarębski, Adrian, Brzózka, Krzysztof, Nowak, Mateusz, Fabritius, Charles‐Henry

“…Energy and biomass production in cancer cells are largely supported by aerobic glycolysis in what is called the Warburg effect. The process is regulated by key…”
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Professional's Attitudes Do Not Influence Screening and Brief Interventions Rates for Hazardous and Harmful Drinkers: Results from ODHIN Study by Bendtsen, Preben, Anderson, Peter, Wojnar, Marcin, Newbury-Birch, Dorothy, Müssener, Ulrika, Colom, Joan, Karlsson, Nadine, Brzózka, Krzysztof, Spak, Fredrik, Deluca, Paolo, Drummond, Colin, Kaner, Eileen, Kłoda, Karolina, Mierzecki, Artur, Okulicz-Kozaryn, Katarzyna, Parkinson, Kathryn, Reynolds, Jillian, Ronda, Gaby, Segura, Lidia, Palacio, Jorge, Baena, Begoña, Slodownik, Luiza, van Steenkiste, Ben, Wolstenholme, Amy, Wallace, Paul, Keurhorst, Myrna N, Laurant, Miranda G H, Gual, Antoni

“…To determine the relation between existing levels of alcohol screening and brief intervention rates in five European jurisdictions and role security and…”
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Small Molecule Screens Identify CDK8-Inhibitors As Candidate Diamond-Blackfan Anemia Drugs by Chen, Jun, Siva, Kavitha, Rzymski, Tomasz, Johansson, Lars, Lundbäck, Thomas, Nunez Villacis, Lorena, Ek, Fredrik, Wang, Bingrui, George, Amee J, Wan, Yang, Shi, Lihong, IIsley, Melissa, Subramaniam, Agatheeswaran, Jain, Mayur, Debnath, Shubhranshu, Ghani Alattar, Abdul, Axelsson, Hanna, Mazan, Milena, Majewska, Eliza, Tedgard, Ulf R., Wlodarski, Marcin W., Gustavsson, Anna-Lena, Olsson, Roger, Mikula, Michal, Zhu, Xiaofan, Brzózka, Krzysztof, Hannan, Ross, Flygare, Johan

“…A safe and efficient therapy for patients with the bone marrow failure syndrome Diamond-Blackfan Anemia (DBA) is urgently needed. To identify novel drug…”
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Impact of primary healthcare providers' initial role security and therapeutic commitment on implementing brief interventions in managing risky alcohol consumption: a cluster randomised factorial trial by Keurhorst, M, Anderson, P, Heinen, M, Bendtsen, Preben, Baena, Begoña, Brzózka, Krzysztof, Colom, Joan, Deluca, Paolo, Drummond, Colin, Kaner, Eileen, Kłoda, Karolina, Mierzecki, Artur, Newbury-Birch, Dorothy, Okulicz-Kozaryn, Katarzyna, Palacio-Vieira, Jorge, Parkinson, Kathryn, Reynolds, Jillian, Ronda, Gaby, Segura, Lidia, Słodownik, Luiza, Spak, Fredrik, van Steenkiste, Ben, Wallace, Paul, Wolstenholme, Amy, Wojnar, Marcin, Gual, Antoni, Laurant, M, Wensing, M

“…Brief interventions in primary healthcare are cost-effective in reducing drinking problems but poorly implemented in routine practice. Although evidence about…”
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Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK Inhibitors by Dreas, Agnieszka, Mikulski, Maciej, Milik, Mariusz, Fabritius, Charles-Henry, Brzózka, Krzysztof, Rzymski, Tomasz

“…MAP kinase-interacting kinases (MNK1 and MNK2) are often activated downstream of ERK and p38 MAPK in the MAP kinase family. The role of MNKs in the development…”
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601 Development of improved small molecule STING agonists suitable for systemic administration by Rogacki, Maciej, Chmielewski, Stefan, Zawadzka, Magdalena, Mazurek, Jolanta, Wnuk-Lipińska, Katarzyna, Kuś, Kamil, Gluza, Karolina, Wójcik-Jaszczyńska, Katarzyna, Poczkaj, Aleksandra, Dudek, Lukasz, Schonemann, Wojciech, Głowniak-Kwitek, Urszula, Leś, Marcin, Wronowski, Marek, Mahajan, Tushar, Kulesza, Urszula, Zastawna, Magdalena, Synak, David, Zuchowicz, Karol, Banaszak, Katarzyna, Wiatrowska, Karolina, Strojny, Izabela, Gładysz, Mirosława, Jabłońska, Justyna, Gabor-Worwa, Ewelina, Tangirala, Raghuram, Stasi, Luigi, Littlewood, Peter, Brzózka, Krzysztof, Dobrzańska, Monika

“…BackgroundStimulator of Interferon Genes (STING) is a major player in the activation of robust innate immune response leading to initiation and enhancement of…”
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Genetic Dissection of Interferon-Antagonistic Functions of Rabies Virus Phosphoprotein: Inhibition of Interferon Regulatory Factor 3 Activation Is Important for Pathogenicity by RIEDER, Martina, BRZOZKA, Krzysztof, PFALLER, Christian K, COX, James H, STITZ, Lothar, CONZELMANN, Karl-Klaus

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The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I by Cui, Sheng, Eisenächer, Katharina, Kirchhofer, Axel, Brzózka, Krzysztof, Lammens, Alfred, Lammens, Katja, Fujita, Takashi, Conzelmann, Karl-Klaus, Krug, Anne, Hopfner, Karl-Peter

“…The ATPase RIG-I senses viral RNAs that contain 5′-triphosphates in the cytoplasm. It initiates a signaling cascade that activates innate immune response by…”
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Physiologically based pharmacokinetic modeling of CYP2C8 substrate rosiglitazone and its metabolite to predict metabolic drug-drug interaction by Gaud, Nilesh, Gogola, Dawid, Kowal-Chwast, Anna, Gabor-Worwa, Ewelina, Littlewood, Peter, Brzózka, Krzysztof, Kus, Kamil, Walczak, Maria

“…Rosiglitazone is an activator of nuclear peroxisome proliferator-activated (PPAR) receptor gamma used in the treatment of type 2 diabetes mellitus. The…”
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Uridine 5′-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro–In Vivo Extrapolation (IVIVE) by Gabor-Worwa, Ewelina, Kowal-Chwast, Anna, Gaud, Nilesh, Gogola, Dawid, Littlewood, Peter, Smoluch, Marek, Brzózka, Krzysztof, Kus, Kamil

“…Background and Objective The prediction of pharmacokinetic parameters for drugs metabolised by cytochrome P450 enzymes has been the subject of active research…”
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FASD Prevalence among Schoolchildren in Poland by Okulicz‐Kozaryn, Katarzyna, Borkowska, Magdalena, Brzózka, Krzysztof

“…Background Prenatal Alcohol Exposure is a major cause of brain damage and developmental delay, known as Fetal Alcohol Spectrum Disorders (FASD) but in Poland…”
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Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma by Szydłowski, Maciej, Prochorec-Sobieszek, Monika, Szumera-Ciećkiewicz, Anna, Derezińska, Edyta, Hoser, Grażyna, Wasilewska, Danuta, Szymańska-Giemza, Olga, Jabłońska, Ewa, Białopiotrowicz, Emilia, Sewastianik, Tomasz, Polak, Anna, Czardybon, Wojciech, Gałęzowski, Michał, Windak, Renata, Zaucha, Jan Maciej, Warzocha, Krzysztof, Brzózka, Krzysztof, Juszczyński, Przemysław

“…Reed-Sternberg (RS) cells of classical Hodgkin lymphoma (cHL) express multiple immunoregulatory proteins that shape the cHL microenvironment and allow tumor…”
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