Search Results - "Bryzgalov, Leonid O"

Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer's Disease by Bryzgalov, Leonid O, Korbolina, Elena E, Merkulova, Tatiana I

“…Alzheimer's disease (AD) is a prevalent type of dementia in elderly populations with a significant genetic component. The accumulating evidence suggests that…”
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A Panel of rSNPs Demonstrating Allelic Asymmetry in Both ChIP-seq and RNA-seq Data and the Search for Their Phenotypic Outcomes through Analysis of DEGs by Korbolina, Elena E., Bryzgalov, Leonid O., Ustrokhanova, Diana Z., Postovalov, Sergey N., Poverin, Dmitry V., Damarov, Igor S., Merkulova, Tatiana I.

“…Currently, the detection of the allele asymmetry of gene expression from RNA-seq data or the transcription factor binding from ChIP-seq data is one of the…”
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Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia by Bryzgalov, Leonid O, Korbolina, Elena E, Brusentsov, Ilja I, Leberfarb, Elena Y, Bondar, Natalia P, Merkulova, Tatiana I

“…A challenge of understanding the mechanisms underlying cognition including neurodevelopmental and neuropsychiatric disorders is mainly given by the potential…”
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Detection of regulatory SNPs in human genome using ChIP-seq ENCODE data by Bryzgalov, Leonid O, Antontseva, Elena V, Matveeva, Marina Yu, Shilov, Alexander G, Kashina, Elena V, Mordvinov, Viatcheslav A, Merkulova, Tatyana I

“…A vast amount of SNPs derived from genome-wide association studies are represented by non-coding ones, therefore exacerbating the need for effective…”
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Novel approach to functional SNPs discovery from genome‐wide data reveals promising variants for colon cancer risk by Korbolina, Elena E., Brusentsov, Ilja I., Bryzgalov, Leonid O., Leberfarb, Elena Yu, Degtyareva, Arina O., Merkulova, Tatyana I.

“…In the majority of colorectal cancer (CRC) cases, the genetic basis of predisposition remains unexplained. The goal of the study was to assess the regulatory…”
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Potentialities of aberrantly methylated circulating DNA for diagnostics and post-treatment follow-up of lung cancer patients by Ponomaryova, Anastasia A, Rykova, Elena Yu, Cherdyntseva, Nadezda V, Skvortsova, Tatiana E, Dobrodeev, Alexey Yu, Zav’yalov, Alexander A, Bryzgalov, Leonid O, Tuzikov, Sergey A, Vlassov, Valentin V, Laktionov, Pavel P

“…Abstract To date, aberrant DNA methylation has been shown to be one of the most common and early causes of malignant cell transformation and tumors of…”
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Application of quantitative trait locus mapping and transcriptomics to studies of the senescence-accelerated phenotype in rats by Korbolina, Elena E, Ershov, Nikita I, Bryzgalov, Leonid O, Kolosova, Natalia G

“…Etiology of complex disorders, such as cataract and neurodegenerative diseases including age-related macular degeneration (AMD), remains poorly understood due…”
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Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene by Antontseva, Elena V, Matveeva, Marina Yu, Bondar, Natalia P, Kashina, Elena V, Leberfarb, Elena Yu, Bryzgalov, Leonid O, Gervas, Polina A, Ponomareva, Anastasia A, Cherdyntseva, Nadezhda V, Orlov, Yury L, Merkulova, Tatiana I

“…There are two regulatory single nucleotide polymorphisms (rSNPs) at the beginning of the second intron of the mouse K-ras gene that are strongly associated…”
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Species-specific effects of the hepatocarcinogens 3′-methyl-4-dimethyl-aminoazobenzene and ortho-aminoazotoluene in mouse and rat liver by Merkulova, Tatyana I., Kropachev, Konstantin Y., Timofeeva, Olga A., Vasiliev, Gennady V., Levashova, Zoia B., Ilnitskaya, Svetlana I., Kobzev, Victor F., Pakharukova, Maria Yu, Bryzgalov, Leonid O., Kaledin, Vasily I.

“…The effects of rat‐specific hepatocarcinogen 3′‐methyl‐4‐dimethylaminoazobenzene (3′‐MeDAB), mouse‐specific hepatocarcinogen ortho‐aminoazotoluene (OAT),…”
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Regulatory single nucleotide polymorphisms (rSNPs) at the promoters 1A and 1B of the human APC gene by Matveeva, Marina Yu, Kashina, Elena V, Reshetnikov, Vasily V, Bryzgalov, Leonid O, Antontseva, Elena V, Bondar, Natalia P, Merkulova, Tatiana I

“…Germline mutations in the coding sequence of the tumour suppressor APC gene give rise to familial adenomatous polyposis (which leads to colorectal cancer) and…”
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Regulatory single nucleotide polymorphisms by Matveeva, Marina Yu, Kashina, Elena V, Reshetnikov, Vasily V, Bryzgalov, Leonid O, Antontseva, Elena V, Bondar, Natalia P, Merkulova, Tatiana I

“…Germline mutations in the coding sequence of the tumour suppressor APC gene give rise to familial adenomatous polyposis (which leads to colorectal cancer) and…”
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