A Novel Adsorbent for Hydrophilic Chromatography Based on Silica Modified by the Ugi Reaction

A Novel Adsorbent for Hydrophilic Chromatography Based on Silica Modified by the Ugi Reaction

New stationary phases for hydrophilic chromatography (HILIC) with functional layers formed by the multicomponent Ugi reaction have been obtained. Acetone, glycolic acid, ethyl isocyanacetate, and 3‑aminopropyl silica, which also act as adsorbent matrices, were used as reaction components. The study...

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Bibliographic Details
Published in:Journal of analytical chemistry (New York, N.Y.) Vol. 76; no. 9; pp. 1083 - 1092
Main Authors: Chikurova, N. Yu, Shemyakina, A. O., Bryskina, D. E., Nuriev, V. N., Komarov, A. A., Statkus, M. A., Stavrianidi, A. N., Chernobrovkina, A. V.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-09-2021
Springer
Springer Nature B.V
Subjects:
Adsorbents
Amino acids
Aminopropyl silica
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chromatography
Comparative analysis
Ethanol
Glycolic acid
Hydrophilicity
Selectivity
Silica
Silicon dioxide
Sugar
Vitamins
Germany
Russia
sugars
water-soluble vitamins
multicomponent Ugi reaction
hydrophilic chromatography
silica
synthesis of adsorbents
amino acids
Tanaka test
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Summary:New stationary phases for hydrophilic chromatography (HILIC) with functional layers formed by the multicomponent Ugi reaction have been obtained. Acetone, glycolic acid, ethyl isocyanacetate, and 3‑aminopropyl silica, which also act as adsorbent matrices, were used as reaction components. The study of the effect of solvent on the reaction yield showed that a high degree of coverage of the matrix was achieved when the reaction was carried out in ethanol. The new adsorbents’ chromatographic properties compared with the initial matrix were assessed using the Tanaka tests for hydrophilic phases and by studying the retention of polar analytes from various classes. The synthesized adsorbents have demonstrated high efficiency and selectivity in separating model mixtures of sugars, amino acids, and water-soluble vitamins in the HILIC mode.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934821090033