Search Results - "Brys, L."

Domains and Maturation Processes That Regulate the Activity of ADAMTS-2, a Metalloproteinase Cleaving the Aminopropeptide of Fibrillar Procollagens Types I–III and V by Colige, Alain, Ruggiero, Florence, Vandenberghe, Isabel, Dubail, Johanne, Kesteloot, Frederic, Van Beeumen, Jozef, Beschin, Alain, Brys, Lea, Lapière, Charles M, Nusgens, Betty

“…Processing of fibrillar collagens is required to generate collagen monomers able to self-assemble into elongated and cylindrical collagen fibrils. ADAMTS-2…”
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Alternative versus classical macrophage activation during experimental African trypanosomosis by DE BAETSELIER, P, NAMANGALA, B, NOËL, W, BRYS, L, PAYS, E, BESCHIN, A

“…African trypanosomes are extracellular parasites causing sleeping sickness to human or nagana to livestock in sub-Saharan Africa. To gain insight into factors…”
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Bacterial Lipoprotein-Based Vaccines Induce Tumor Necrosis Factor-Dependent Type 1 Protective Immunity against Leishmania major by COTE-SIERRA, Javier, BREDAN, Amin, TOLDOS, Carmen M, STIJLEMANS, Benoit, BRYS, Lea, CORNELIS, Pierre, SEGOVIA, Manuel, DE BAETSELIER, Patrick, REVETS, Hilde

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Trypanosoma brucei infection elicits nitric oxide-dependent and nitric oxide-independent suppressive mechanisms by Beschin, Alain, Brys, Lea, Magez, Stefan, Radwanska, Magda, De Baetselier, Patrick

“…During murine Trypanosoma brucei infection, macrophages contribute significantly to the inhibition of T cell responses. Although nitric oxide (NO) was shown to…”
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In vitro simulation of immunosuppression caused by Trypanosoma brucei: active involvement of gamma interferon and tumor necrosis factor in the pathway of suppression by DARJI, A, BESCHIN, A, SILEGHEM, M, HEREMANS, H, BRYS, L, DE BAETSELIER, P, MANSFIELD, J. M

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Trypanosoma brucei brucei infection impairs MHC class II antigen presentation capacity of macrophages by Namangala, B, Brys, L, Magez, S, De Baetselier, P, Beschin, A

“…During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite‐related and unrelated antigens. In this study, the…”
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Inhibition of T-cell responsiveness during experimental infections with Trypanosoma brucei: active involvement of endogenous gamma interferon by DARJI, A, SILEGHEM, M, HEREMANS, H, BRYS, L, DE BAETSELIER, P

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Intrabody Targeting HIF-1α Mediates Transcriptional Downregulation of Target Genes Related to Solid Tumors by Hu, Yaozhong, Romão, Ema, Vincke, Cécile, Brys, Lea, Elkrim, Yvon, Vandevenne, Marylène, Liu, Changxiao, Muyldermans, Serge

“…Uncontrolled growth of solid tumors will result in a hallmark hypoxic condition, whereby the key transcriptional regulator of hypoxia inducible factor-1α…”
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Isolation and characterization of single-chain Fv genes encoding antibodies specific for Drosophila Poxn protein by Hassanzadeh Gh, Gholamreza, De Silva, Kumudu S.K., Dambly-Chaudière, Christine, Brys, Lea, Ghysen, Alain, Hamers, Raymond, Muyldermans, Serge, De Baetselier, Patrick

“…The usefulness of intrabodies as specific inhibitors of gene function has been extensively demonstrated in cell culture assays. However, very few experiments…”
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Active antitumor immunotherapy, with or without B7-mediated costimulation, increases tumor progression in an immunogenic murine T cell lymphoma model by Raes, G, Van Ginderachter, J, Liu, Y Q, Brys, L, Thielemans, K, De Baetselier, P, Geldhof, A

“…BW-Sp3 is a BW-5147-derived T cell lymphoma with limited immunogenicity since, despite regression of the majority of subcutaneous tumors, an important fraction…”
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Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation by Raes, G, Brys, L, Dahal, B K, Brandt, J, Grooten, J, Brombacher, F, Vanham, G, Noel, W, Bogaert, P, Boonefaes, T, Kindt, A, Van den Bergh, R, Leenen, PJM, De Baetselier, P, Ghassabeh, G H

“…Molecular markers, especially surface markers associated with type II, cytokine‐dependent, alternatively activated macrophages (aaMF), remain scarce. Besides…”
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Reactive Oxygen Species and 12/15-Lipoxygenase Contribute to the Antiproliferative Capacity of Alternatively Activated Myeloid Cells Elicited during Helminth Infection by Brys, Lea, Beschin, Alain, Raes, Geert, Ghassabeh, Gholamreza Hassanzadeh, Noel, Wim, Brandt, Jef, Brombacher, Frank, Baetselier, Patrick De

“…Understanding the role of CD11b(+)GR-1(+) myeloid suppressor cells in the immune suppression and immunoregulation associated with a variety of diseases may…”
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Relative Contribution of Interferon-γ and Interleukin-10 to Resistance to Murine African Trypanosomosis by Namangala, Boniface, Noël, Wim, De Baetselier, Patrick, Brys, Lea, Beschin, Alain

“…Resistance to Trypanosoma brucei brucei has been correlated with the ability of infected animals to produce interferon (IFN)–γ and tumor necrosis factor (TNF)…”
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Secretory Leukocyte Protease Inhibitor Promotes the Tumorigenic and Metastatic Potential of Cancer Cells by Devoogdt, Nick, Ghassabeh, Gholamreza Hassanzadeh, Zhang, Jing, Brys, Lea, De Baetselier, Patrick, Revets, Hilde

“…Because of their ability to inhibit proteases, protease inhibitors have generally been considered to counteract tumor progression and metastasis. However,…”
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Nitric Oxide-Independent CTL Suppression during Tumor Progression: Association with Arginase-Producing (M2) Myeloid Cells by Liu, Yuanqing, Van Ginderachter, Jo A, Brys, Lea, De Baetselier, Patrick, Raes, Geert, Geldhof, Anja B

“…Most of the mice bearing a s.c. BW-Sp3 lymphoma tumor mount a CD8(+) T cell-mediated response resulting in tumor regression. Nonetheless, tumor progression…”
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Nonmetastatic tumor cells acquire metastatic properties following somatic hybridization with normal cells by De Baetselier, P, Roos, E, Brys, L, Remels, L, Gobert, M, Dekegel, D, Segal, S, Feldman, M

“…Somatic cell hybridization between nonmetastatic tumor cells and normal cells of the lymphoreticular system results in hybrid cells manifesting metastatic…”
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Analysis of HIV infections in human macrophage-like cell lines by Brys, L, Van Gyseghem, A, Verhaegen, S, Saman, E, De Baetselier, P

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Differential presentation of hepatitis B S-preS(2) particles and peptides by macrophages and B-cell like antigen-presenting cells by SCHEERLINCK, J.-P. Y, BURSSENS, G, BRYS, L, MICHEL, A, HAUSER, P, DE BAETSELIER, P

“…Different cell types, including dendritic cells, macrophages and Ia+ B cells, have been described to present soluble antigen (Ag) to T-cell hybridomas…”
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Identification and cloning of a glucan- and lipopolysaccharide-binding protein from Eisenia foetida earthworm involved in the activation of prophenoloxidase cascade by Beschin, A, Bilej, M, Hanssens, F, Raymakers, J, Van Dyck, E, Revets, H, Brys, L, Gomez, J, De Baetselier, P, Timmermans, M

“…Coelomic fluid of Eisenia foetida earthworms contains a 42-kDa protein named coelomic cytolytic factor 1 (CCF-1) that was described previously to be involved…”
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Engineering Camel Single-Domain Antibodies and Immobilization Chemistry for Human Prostate-Specific Antigen Sensing by Saerens, Dirk, Frederix, Filip, Reekmans, Gunter, Conrath, Katja, Jans, Karolien, Brys, Lea, Huang, Lieven, Bosmans, Eugène, Maes, Guido, Borghs, Gustaaf, Muyldermans, Serge

“…The specificity and affinity characteristics of antibodies make them excellent probes in biosensor applications. Unfortunately, their large size, unstable…”
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