Search Results - "Bryer, J"

Full scale structural, mechanical and dynamical properties of HIV-1 liposomes by Bryer, Alexander J, Reddy, Tyler, Lyman, Edward, Perilla, Juan R

“…Enveloped viruses are enclosed by a lipid membrane inside of which are all of the components necessary for the virus life cycle; viral proteins, the viral…”
Get full text

Performance efficient macromolecular mechanics via sub-nanometer shape based coarse graining by Bryer, Alexander J., Rey, Juan S., Perilla, Juan R.

“…Dimensionality reduction via coarse grain modeling is a valuable tool in biomolecular research. For large assemblies, ultra coarse models are often…”
Get full text

Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR by Lu, Manman, Russell, Ryan W., Bryer, Alexander J., Quinn, Caitlin M., Hou, Guangjin, Zhang, Huilan, Schwieters, Charles D., Perilla, Juan R., Gronenborn, Angela M., Polenova, Tatyana

“…HIV-1 capsid plays multiple key roles in viral replication, and inhibition of capsid assembly is an attractive target for therapeutic intervention. Here, we…”
Get full text

Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization by Gres, Anna T., Kirby, Karen A., McFadden, William M., Du, Haijuan, Liu, Dandan, Xu, Chaoyi, Bryer, Alexander J., Perilla, Juan R., Shi, Jiong, Aiken, Christopher, Fu, Xiaofeng, Zhang, Peijun, Francis, Ashwanth C., Melikyan, Gregory B., Sarafianos, Stefan G.

“…HIV-1 capsid (CA) stability is important for viral replication. E45A and P38A mutations enhance and reduce core stability, thus impairing infectivity…”
Get full text

Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA by Cingolani, Gino, McCauley, Michael, Lobley, Anna, Bryer, Alexander J., Wesolowski, Jordan, Greco, Deanna L., Lokareddy, Ravi K., Ronzone, Erik, Perilla, Juan R., Paumet, Fabienne

“…Many intracellular bacteria, including Chlamydia , establish a parasitic membrane-bound organelle inside the host cell that is essential for the bacteria’s…”
Get full text

Curvature of the Retroviral Capsid Assembly Is Modulated by a Molecular Switch by Thames, Tyrone, Bryer, Alexander J, Qiao, Xin, Jeon, Jaekyun, Weed, Ryan, Janicki, Kaylie, Hu, Bingwen, Gor’kov, Peter L, Hung, Ivan, Gan, Zhehong, Perilla, Juan R, Chen, Bo

“…During the maturation step, the retroviral capsid proteins (CAs) assemble into polymorphic capsids. Their acute curvature is largely determined by 12 pentamers…”
Get full text

Accelerating prediction of chemical shift of protein structures on GPUs: Using OpenACC by Wright, Eric, Ferrato, Mauricio H, Bryer, Alexander J, Searles, Robert, Perilla, Juan R, Chandrasekaran, Sunita

“…Experimental chemical shifts (CS) from solution and solid state magic-angle-spinning nuclear magnetic resonance (NMR) spectra provide atomic level information…”
Get full text

Exploring Catalase and Invertase Activity Using Sodium Alginate-Encapsulated Yeast (Yeast Spheres) by Bryer, Pamela J

“…Finding the right enzyme experiment can be problematic, depending what one is trying to show, what supplies and equipment are available, and the time one can…”
Get full text

Deep-learning in situ classification of HIV-1 virion morphology by Rey, Juan S., Li, Wen, Bryer, Alexander J., Beatson, Hagan, Lantz, Christian, Engelman, Alan N., Perilla, Juan R.

“…[Display omitted] •Efficient classifier capable of overcoming inherent problems of small-data training sets.•Automated detection and classification of HIV-1…”
Get full text

Real life experience confirms sustained response to long-term biologics and switching in ankylosing spondylitis by Coates, L. C., Cawkwell, L. S., Ng, N. W. F., Bennett, A. N., Bryer, D. J., Fraser, A. D., Emery, P., Marzo-Ortega, H.

“…Objective. To investigate the long-term response to biological therapies in AS in a real life clinical setting and to quantify non-response and response to…”
Get full text

A retrospective analysis of venous thromboembolism trends in chemotherapy‐induced anemia: Red blood cell transfusion versus erythrocyte stimulating agent administration by Bryer, Emily J., Kallan, Michael J., Chiu, Ting‐Shan, Scheuba, Katharina M., Henry, David H.

“…Background Patients receiving a variety of chemotherapy regimens often develop chemotherapy‐induced anemia (CIA), which contributes to poor outcomes including…”
Get full text

Sustained response to long-term biologics and switching in psoriatic arthritis: results from real life experience by Coates, L C, Cawkwell, L S, Ng, N W F, Bennett, A N, Bryer, D J, Fraser, A D, Emery, P, Marzo-Ortega, H

“…To investigate the response to biologic drugs in psoriatic arthritis and to quantify non-response and outcome from switching agents. 60 patients (33 men and 27…”
Get more information

Elasticity of the HIV-1 core facilitates nuclear entry and infection by Deshpande, Akshay, Bryer, Alexander J, Andino-Moncada, Jonathan R, Shi, Jiong, Hong, Jun, Torres, Cameron, Harel, Shimon, Francis, Ashwanth C, Perilla, Juan R, Aiken, Christopher, Rousso, Itay

“…HIV-1 infection requires passage of the viral core through the nuclear pore of the cell, a process that depends on functions of the viral capsid. Recent…”
Get full text

Space requirements of weaned pigs during a sixty-minute transport in summer by Sutherland, M.A, Bryer, P.J, Davis, B.L, McGlone, J.J

“…Currently, there are no trucking quality assurance recommendations for space allowance of weaned pigs during transport in the United States. The objective of…”
Get full text

Recognition of the TDP-43 nuclear localization signal by importin α1/β by Doll, Steven G, Meshkin, Hamed, Bryer, Alexander J, Li, Fenglin, Ko, Ying-Hui, Lokareddy, Ravi K, Gillilan, Richard E, Gupta, Kushol, Perilla, Juan R, Cingolani, Gino

“…Cytoplasmic mislocalization of the TAR-DNA binding protein of 43 kDa (TDP-43) leads to large, insoluble aggregates that are a hallmark of amyotrophic lateral…”
Get full text

High-Performance Analysis of Biomolecular Containers to Measure Small-Molecule Transport, Transbilayer Lipid Diffusion, and Protein Cavities by Bryer, Alexander J, Hadden-Perilla, Jodi A, Stone, John E, Perilla, Juan R

“…Compartmentalization is a central theme in biology. Cells are composed of numerous membrane-enclosed structures, evolved to facilitate specific biochemical…”
Get full text

Molecular dynamics of the viral life cycle: progress and prospects by Jones, Peter Eugene, Pérez-Segura, Carolina, Bryer, Alexander J, Perilla, Juan R, Hadden-Perilla, Jodi A

“…•Molecular dynamics simulations are the central technique uniting the field of computational virology.•Viruses responsible for recent epidemics and pandemics…”
Get full text

Chemosensory assessment of predation risk by slimy sculpins (Cottus cognatus) : Responses to alarm, disturbance, and predator cues by BRYER, Pamela J, MIRZA, Reehan S, CHIVERS, Douglas P

“…Slimy sculpins (Cottus cognatus) are small benthic fish that commonly co-occur with predatory fishes throughout most of their range in North America. In two…”
Get full text

Childhood sexual and physical abuse as factors in adult psychiatric illness by Bryer, J B, Nelson, B A, Miller, J B, Krol, P A

“…Using objective measures, the authors found a high rate of childhood sexual and physical abuse in a sample of 66 female psychiatric inpatients. Childhood abuse…”
Get more information

organic research network project on the central coast of California by Muramoto, J, Gliessman, S.R, Shennan, C, Pisani Gareau, T, Monsen, K.L, Pedersen, S, Bolda, M.P, Daugovish, O, Bull, C.T, Li, C, Leap, J, Nieto, D, Bryer, J, Koike, S.T, Smith, R.F, Gaskell, M

“…The California organic agriculture industry has grown in size and consumer acceptance despite a very limited scientific research base. The Organic Research…”
Get full text