Search Results - "Brychzy, Alexander"
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Role of Transforming Growth Factor-α in von Hippel-Lindau (VHL)-/-Clear Cell Renal Carcinoma Cell Proliferation: A Possible Mechanism Coupling VHL Tumor Suppressor Inactivation and Tumorigenesis
Published in Proceedings of the National Academy of Sciences - PNAS (13-02-2001)“…Mutations of the VHL tumor suppressor gene occur in patients with VHL disease and in the majority of sporadic clear cell renal carcinomas (VHL-/-RCC). Loss of…”
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novel HSP90 chaperone complex regulates intracellular vesicle transport
Published in Journal of cell science (01-03-2008)“…Heat shock protein 90 (HSP90) is considered a specialized molecular chaperone that controls the folding of cell-regulatory proteins such as steroid receptors…”
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Conjugation of the Ubiquitin-Like Protein NEDD8 to Cullin-2 Is Linked to Von Hippel-Lindau Tumor Suppressor Function
Published in Proceedings of the National Academy of Sciences - PNAS (11-05-1999)“…The von Hippel-Lindau tumor suppressor protein pVHL assembles with cullin-2 (hCUL-2) and elongin B/C forming a protein complex, CBCVHL, that resembles…”
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Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
Published in The EMBO journal (15-07-2003)“…In the eukaryotic cytosol, Hsp70 and Hsp90 cooperate with various co‐chaperone proteins in the folding of a growing set of substrates, including the…”
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Role of transforming growth factor-alpha in von Hippel-Lindau (VHL)-/- clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppression
Published in Proceedings of the National Academy of Sciences - PNAS (13-02-2001)“…Mutations of the VHL tumor suppressor gene occur in patients with VHL disease and in the majority of sporadic clear cell renal carcinomas (VHL -/- RCC). Loss…”
Get full text
Journal Article -
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Role of transforming growth factor-α in von Hippel– Lindau (VHL) −/− clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis
Published in Proceedings of the National Academy of Sciences - PNAS (13-02-2001)“…Mutations of the VHL tumor suppressor gene occur in patients with VHL disease and in the majority of sporadic clear cell renal carcinomas (VHL −/− RCC). Loss…”
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Journal Article