Search Results - "Brychzy, Alexander"

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    novel HSP90 chaperone complex regulates intracellular vesicle transport by Lotz, Gregor P, Brychzy, Alexander, Heinz, Stefan, Obermann, Wolfgang M.J

    Published in Journal of cell science (01-03-2008)
    “…Heat shock protein 90 (HSP90) is considered a specialized molecular chaperone that controls the folding of cell-regulatory proteins such as steroid receptors…”
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    Journal Article
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    Conjugation of the Ubiquitin-Like Protein NEDD8 to Cullin-2 Is Linked to Von Hippel-Lindau Tumor Suppressor Function by Liakopoulos, Dimitris, Büsgen, Tanja, Brychzy, Alexander, Jentsch, Stefan, Pause, Arnim

    “…The von Hippel-Lindau tumor suppressor protein pVHL assembles with cullin-2 (hCUL-2) and elongin B/C forming a protein complex, CBCVHL, that resembles…”
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    Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system by Young, Jason C, Brychzy, Alexander, Rein, Theo, Winklhofer, Konstanze F, Hartl, F.Ulrich, Obermann, Wolfgang M.J

    Published in The EMBO journal (15-07-2003)
    “…In the eukaryotic cytosol, Hsp70 and Hsp90 cooperate with various co‐chaperone proteins in the folding of a growing set of substrates, including the…”
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    Role of transforming growth factor-alpha in von Hippel-Lindau (VHL)-/- clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppression by de Paulsen, Natalie, Brychzy, Alexander, Fournier, Marie-Christine, Klausner, Richard D

    “…Mutations of the VHL tumor suppressor gene occur in patients with VHL disease and in the majority of sporadic clear cell renal carcinomas (VHL -/- RCC). Loss…”
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    Journal Article
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