Search Results - "Bryce, Dianne K."

Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism by Silverman, Jill L, Smith, Daniel G, Rizzo, Stacey J Sukoff, Karras, Michael N, Turner, Sarah M, Tolu, Seda S, Bryce, Dianne K, Smith, Deborah L, Fonseca, Kari, Ring, Robert H, Crawley, Jacqueline N

“…Neurodevelopmental disorders such as autism and fragile X syndrome were long thought to be medically untreatable, on the assumption that brain dysfunctions…”
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Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574 by Shaffer, Christopher L, Hurst, Raymond S, Scialis, Renato J, Osgood, Sarah M, Bryce, Dianne K, Hoffmann, William E, Lazzaro, John T, Hanks, Ashley N, Lotarski, Susan, Weber, Mark L, Liu, JianHua, Menniti, Frank S, Schmidt, Christopher J, Hajós, Mihály

“…α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) positive allosteric modulation (i.e., "potentiation") has been proposed to overcome…”
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Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity by Bryce, Dianne K, Ware, Chris M, Woodhouse, Janice D, Ciaccio, Paul J, Ellis, J Michael, Hegde, Laxminarayan G, Kuruvilla, Sabu, Maddess, Matthew L, Markgraf, Carrie G, Otte, Karin M, Poulet, Frederique M, Timmins, Lauren M, Kennedy, Matthew E, Fell, Matthew J

“…Gain-of-function mutations in leucine-rich kinase 2 (LRRK2) are associated with increased incidence of Parkinson disease (PD); thus, pharmacological inhibition…”
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The Discovery and Characterization of the α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N‑{(3S,4S)‑4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242) by Shaffer, Christopher L, Patel, Nandini C, Schwarz, Jacob, Scialis, Renato J, Wei, Yunjing, Hou, Xinjun J, Xie, Longfei, Karki, Kapil, Bryce, Dianne K, Osgood, Sarah M, Hoffmann, William E, Lazzaro, John T, Chang, Cheng, McGinnis, Dina F, Lotarski, Susan M, Liu, JianHua, Obach, R. Scott, Weber, Mark L, Chen, Laigao, Zasadny, Kenneth R, Seymour, Patricia A, Schmidt, Christopher J, Hajós, Mihály, Hurst, Raymond S, Pandit, Jayvardhan, O’Donnell, Christopher J

“…A unique tetrahydrofuran ether class of highly potent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor potentiators has been identified using…”
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Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models by O'Donnell, Christopher J, Rogers, Bruce N, Bronk, Brian S, Bryce, Dianne K, Coe, Jotham W, Cook, Karen K, Duplantier, Allen J, Evrard, Edelweiss, Hajós, Mihaly, Hoffmann, William E, Hurst, Raymond S, Maklad, Noha, Mather, Robert J, McLean, Stafford, Nedza, Frank M, O'Neill, Brian T, Peng, Langu, Qian, Weimin, Rottas, Melinda M, Sands, Steven B, Schmidt, Anne W, Shrikhande, Alka V, Spracklin, Douglas K, Wong, Diane F, Zhang, Andy, Zhang, Lei

“…A novel alpha 7 nAChR agonist, 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (24, CP-810,123), has been identified as a potential…”
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Discovery and Characterization of a Novel Dihydroisoxazole Class of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators by Patel, Nandini C, Schwarz, Jacob, Hou, Xinjun J, Hoover, Dennis J, Xie, Longfei, Fliri, Anton J, Gallaschun, Randall J, Lazzaro, John T, Bryce, Dianne K, Hoffmann, William E, Hanks, Ashley N, McGinnis, Dina, Marr, Eric S, Gazard, Justin L, Hajós, Mihály, Scialis, Renato J, Hurst, Raymond S, Shaffer, Christopher L, Pandit, Jayvardhan, O’Donnell, Christopher J

“…Positive allosteric modulators (“potentiators”) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) enhance excitatory…”
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Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models by O’Donnell, Christopher J, Rogers, Bruce N, Bronk, Brian S, Bryce, Dianne K, Coe, Jotham W, Cook, Karen K, Duplantier, Allen J, Evrard, Edelweiss, Hajós, Mihaly, Hoffmann, William E, Hurst, Raymond S, Maklad, Noha, Mather, Robert J, McLean, Stafford, Nedza, Frank M, O’Neill, Brian T, Peng, Langu, Qian, Weimin, Rottas, Melinda M, Sands, Steven B, Schmidt, Anne W, Shrikhande, Alka V, Spracklin, Douglas K, Wong, Diane F, Zhang, Andy, Zhang, Lei

“…A novel α7 nAChR agonist, 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (24, CP-810,123), has been identified as a potential treatment…”
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Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK$_1$) Receptor Antagonist by McLean, Stafford, Ganong, Alan H., Seeger, Thomas F., Bryce, Dianne K., Pratt, Kara G., Reynolds, Linda S., Siok, Chester J., Lowe, John A., Heym, James

“…CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK$_1$ receptor. The compound binds to a single population of sites in guinea…”
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Biaryl piperidines as potent and selective delta opioid receptor ligands by Liras, Spiros, McHardy, Stanton F., Allen, Martin P., Segelstein, Barb E., Heck, Steven D., Bryce, Dianne K., Schmidt, Anne W., Vanase-Frawley, Michelle, Callegari, Ernesto, McLean, Stafford

“…The design and synthesis of novel opiates are reported. Based on the message-address principle a novel class of 4,4- and 3,3-biaryl piperidines was designed…”
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5-Phenyl-3-ureidobenzazepin-2-ones as Cholecystokinin-B Receptor Antagonists by Lowe, John A, Hageman, David L, Drozda, Susan E, McLean, Stafford, Bryce, Dianne K, Crawford, Rosemary T, Zorn, Stevin, Morrone, Jean, Bordner, Jon

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The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine as a novel, nonpeptide substance P antagonist by Lowe, John A, Drozda, Susan E, Snider, R. Michael, Longo, Kelly P, Zorn, Stevin H, Morrone, Jean, Jackson, Elisa R, McLean, Stafford, Bryce, Dianne K

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Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist by Rosen, Terry J., Coffman, Karen J., McLean, Stafford, Crawford, Rosemary T., Bryce, Dianne K., Gohda, Yoshiko, Tsuchiya, Megumi, Nagahisa, Atsushi, Nakane, Masami, Lowe, John A.

“…The synthesis and SAR of benzylamine side chain analogs of the NK-1 receptor antagonist CP-99,994 are described. The 5-trifluoromethoxy analog, CP-122,721,…”
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Synthesis of conformationally restricted substance P antagonists by Howard, Harry R., Shenk, Kevin D., Coffman, Karen C., Bryce, Dianne K., Crawford, Rosemary T., McLean, Stafford A.

“…Reaction of CP-99,994 ( 1) with benzyl chloromethyl ether under basic conditions produced the novel 1,6-diazabicyclo[3.2.1]octane system in good yield; analogs…”
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Discovery of CP-96,345 and its characterization in disease models involving substance P by Lowe, 3rd, J A, Drozda, S E, Snider, R M, Longo, K P, Zorn, S H, Jackson, E R, Morrone, J, McLean, S, Bryce, D K, Bordner, J

“…Studies with CP-96,345, a potent, selective, orally active, nonpeptide NK1 receptor antagonist, have provided considerable insight into SP pharmacology. Rather…”
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The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine as a novel, nonpeptide substance P antagonist. [Erratum to document cited in CA117(5):48289n] by Lowe, John A, Drozda, Susan E, Snider, R. Michael, Longo, Kelly P, Zorn, Stevin H, Morrone, Jean, Jackson, Elisa R, McLean, Stafford, Bryce, Dianne K

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Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel μ opioid receptor ligands by ALLEN, M. P, BLAKE, J. F, BRYCE, D. K, HAGGAN, M. E, LIRAS, S, MCLEAN, S, SEGELSTEIN, B. E

“…3-Amino-3-phenylpropionamide derivatives were produced as small molecule mimics of the cyclic octapeptide octreotide from readily available imine 1. The…”
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Aza-Tricyclic Substance P Antagonists by Lowe, John A, Drozda, Susan E, McLean, Stafford, Bryce, D. K, Crawford, Rosemary T, Snider, R. Michael, Longo, Kelly P, Nagahisa, Atsushi, Tsuchiya, Megumi

“…The synthesis and structure-activity relationships of a series of aza-tricyclic analogs of the quinuclidine substance P (SP) antagonist 1 are described. The SP…”
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A water soluble benzazepine cholecystokinin-B receptor antagonist by Lowe, John A., Drozda, Susan E., McLean, Stafford, Bryce, Dianne K., Crawford, Rosemary T., Zorn, Stevin, Morrone, Jean, Appleton, Troy A., Lombardo, Franco

“…A series of 5-substituted-3-ureidobenzazepin-2-ones bearing ioizable functionality was synthesized as potential cholecystokinin-B (CCK-B) receptor antagonists…”
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Design of novel cholecystokinin-B receptor ligands based on the ‘double-ring system’ approach by Lowe, John A., Qian, Weimin, McLean, Stafford, Bryce, Dianne K., Crawford, Rosemary T., Olsson, Linnea C., Bordner, Jon

“…A structurally novel series of cholecystokinin-B (CCK-B) receptor ligands has been designed and synthesized based on the ‘double-ring system’ theory of…”
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