Search Results - "Bryant, Stephanie"
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The role of chondroitin sulfate in regulating hypertrophy during MSC chondrogenesis in a cartilage mimetic hydrogel under dynamic loading
Published in Biomaterials (01-01-2019)“…Mesenchymal stem cells (MSCs) are promising for cartilage regeneration, but readily undergo terminal differentiation. The aim of this study was two-fold: a)…”
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Mechanics of 3D Cell–Hydrogel Interactions: Experiments, Models, and Mechanisms
Published in Chemical reviews (22-09-2021)“…Hydrogels are highly water-swollen molecular networks that are ideal platforms to create tissue mimetics owing to their vast and tunable properties. As such,…”
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The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels
Published in Journal of biomedical materials research. Part A (01-06-2012)“…Poly(ethylene glycol) (PEG) hydrogels, modified with RGD, are promising platforms for cell encapsulation and tissue engineering. While these hydrogels offer…”
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Comparison of photopolymerizable thiol-ene PEG and acrylate-based PEG hydrogels for cartilage development
Published in Biomaterials (01-12-2013)“…Abstract When designing hydrogels for tissue regeneration, differences in polymerization mechanism and network structure have the potential to impact cellular…”
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Understanding and Improving Mechanical Properties in 3D printed Parts Using a Dual‐Cure Acrylate‐Based Resin for Stereolithography
Published in Advanced engineering materials (01-12-2018)“…Application of 3D printed structures via stereolithography (SLA) is limited by imprecise dimensional control and inferior mechanical properties. These…”
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Hydrolytically Degradable Poly(β‐amino ester) Resins with Tunable Degradation for 3D Printing by Projection Micro‐Stereolithography
Published in Advanced functional materials (01-02-2022)“…Applications of 3D printing that range from temporary medical devices to environmentally responsible manufacturing will benefit from printable resins that…”
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Cell encapsulation spatially alters crosslink density of poly(ethylene glycol) hydrogels formed from free-radical polymerizations
Published in Acta biomaterialia (01-06-2020)“…Photopolymerizable poly(ethylene glycol) (PEG) hydrogels are a promising platform for chondrocyte encapsulation and cartilage tissue engineering. This study…”
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An in vitro and in vivo comparison of cartilage growth in chondrocyte-laden matrix metalloproteinase-sensitive poly(ethylene glycol) hydrogels with localized transforming growth factor β3
Published in Acta biomaterialia (15-07-2019)“…[Display omitted] While matrix-assisted autologous chondrocyte implantation has emerged as a promising therapy to treat focal chondral defects, matrices that…”
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Nondestructive evaluation of a new hydrolytically degradable and photo-clickable PEG hydrogel for cartilage tissue engineering
Published in Acta biomaterialia (15-07-2016)“…Non-destructive measurements capture neo-cartilage matrix (green) evolution in a new photo-clickable and degradable hydrogel with encapsulated cartilage cells…”
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Cell encapsulation in biodegradable hydrogels for tissue engineering applications
Published in Tissue engineering. Part B, Reviews (01-06-2008)“…Encapsulating cells in biodegradable hydrogels offers numerous attractive features for tissue engineering, including ease of handling, a highly hydrated…”
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Linking the foreign body response and protein adsorption to PEG-based hydrogels using proteomics
Published in Biomaterials (01-02-2015)“…Abstract Poly(ethylene glycol) (PEG) hydrogels with their highly tunable properties are promising implantable materials, but as with all non-biological…”
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Tuning tissue growth with scaffold degradation in enzyme-sensitive hydrogels: a mathematical model
Published in Soft matter (01-01-2016)“…Despite tremendous advances in the field of tissue engineering, a number of obstacles remain that hinder its successful translation to the clinic. One…”
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The Effects of Stably Tethered BMP‑2 on MC3T3-E1 Preosteoblasts Encapsulated in a PEG Hydrogel
Published in Biomacromolecules (08-03-2021)“…Bone morphogenetic protein-2 (BMP-2) is a clinically used osteoinductive growth factor. With a short half-life and side effects, alternative delivery…”
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Programmable Hydrogels for Cell Encapsulation and Neo‐Tissue Growth to Enable Personalized Tissue Engineering
Published in Advanced healthcare materials (01-01-2018)“…Biomimetic and biodegradable synthetic hydrogels are emerging as a promising platform for cell encapsulation and tissue engineering. Notably, synthetic‐based…”
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The In Vitro and In Vivo Response to MMP-Sensitive Poly(Ethylene Glycol) Hydrogels
Published in Annals of biomedical engineering (01-06-2016)“…Enzyme-sensitive hydrogels are a promising class of materials for cell encapsulation and tissue engineering because their ability to be degraded by…”
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Tethering transforming growth factor β1 to soft hydrogels guides vascular smooth muscle commitment from human mesenchymal stem cells
Published in Acta biomaterialia (15-03-2020)“…Mesenchymal stem cells (MSCs) hold great promise for vascular smooth muscle regeneration. However, most studies have mainly relied on extended supplementation…”
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The effects of processing variables on electrospun poly(ethylene glycol) fibrous hydrogels formed from the thiol‐norbornene click reaction
Published in Journal of applied polymer science (20-08-2021)“…Electrospinning has been used to create scaffolds with tunable micro/nano architecture, stiffness, and porosity to mimic native extracellular matrix. This…”
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A comparison of human mesenchymal stem cell osteogenesis in poly(ethylene glycol) hydrogels as a function of MMP‐sensitive crosslinker and crosslink density in chemically defined medium
Published in Biotechnology and bioengineering (01-06-2019)“…This study investigated osteogenesis of human mesenchymal stem cells encapsulated in matrix‐metalloproteinase (MMP)‐sensitive poly(ethylene glycol) (PEG)…”
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A MMP7‐sensitive photoclickable biomimetic hydrogel for MSC encapsulation towards engineering human cartilage
Published in Journal of biomedical materials research. Part A (01-08-2018)“…Cartilage tissue engineering strategies that use in situ forming degradable hydrogels for mesenchymal stem cell (MSC) delivery are promising for treating…”
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Zwitterionic PEG-PC Hydrogels Modulate the Foreign Body Response in a Modulus-Dependent Manner
Published in Biomacromolecules (09-07-2018)“…Reducing the foreign body response (FBR) to implanted biomaterials will enhance their performance in tissue engineering. Poly(ethylene glycol) (PEG) hydrogels…”
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