Search Results - "Bryant, Patrick"

Improved prediction of protein-protein interactions using AlphaFold2 by Bryant, Patrick, Pozzati, Gabriele, Elofsson, Arne

“…Predicting the structure of interacting protein chains is a fundamental step towards understanding protein function. Unfortunately, no computational method can…”
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Structure prediction of alternative protein conformations by Bryant, Patrick, Noé, Frank

“…Proteins are dynamic molecules whose movements result in different conformations with different functions. Neural networks such as AlphaFold2 can predict the…”
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Improved protein complex prediction with AlphaFold-multimer by denoising the MSA profile by Bryant, Patrick, Noé, Frank

“…Structure prediction of protein complexes has improved significantly with AlphaFold2 and AlphaFold-multimer (AFM), but only 60% of dimers are accurately…”
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Predicting the structure of large protein complexes using AlphaFold and Monte Carlo tree search by Bryant, Patrick, Pozzati, Gabriele, Zhu, Wensi, Shenoy, Aditi, Kundrotas, Petras, Elofsson, Arne

“…AlphaFold can predict the structure of single- and multiple-chain proteins with very high accuracy. However, the accuracy decreases with the number of chains,…”
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Estimating the impact of mobility patterns on COVID-19 infection rates in 11 European countries by Bryant, Patrick, Elofsson, Arne

“…As governments across Europe have issued non-pharmaceutical interventions (NPIs) such as social distancing and school closing, the mobility patterns in these…”
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Structure prediction of protein-ligand complexes from sequence information with Umol by Bryant, Patrick, Kelkar, Atharva, Guljas, Andrea, Clementi, Cecilia, Noé, Frank

“…Protein-ligand docking is an established tool in drug discovery and development to narrow down potential therapeutics for experimental testing. However, a…”
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Author Correction: Improved prediction of protein-protein interactions using AlphaFold2 by Bryant, Patrick, Pozzati, Gabriele, Elofsson, Arne

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Peptide binder design with inverse folding and protein structure prediction by Bryant, Patrick, Elofsson, Arne

“…The computational design of peptide binders towards a specific protein interface can aid diagnostic and therapeutic efforts. Here, we design peptide binders by…”
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Streamlined Whole-Genome Sequencing of Mumps Virus for High-Resolution Outbreak Analysis by Bryant, Patrick, Caldwell, Haley, Lamson, Daryl M, Yildirim, Tugba, St George, Kirsten

“…Since 2015, the United States has experienced a resurgence in the number of mumps cases and outbreaks in fully vaccinated populations. These outbreaks have…”
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A custom hepatitis A virus assay for whole-genome sequencing by Cleary, Nora G., Bryant, Patrick W., Lamson, Daryl M., Newman, Alexandra P., St. George, Kirsten

“…Since 2016, the United States has experienced a resurgence in the number of hepatitis A virus (HAV) cases and outbreaks. These outbreaks have been sustained by…”
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A Swedish Familial Genome-Wide Haplotype Analysis Identified Five Novel Breast Cancer Susceptibility Loci on 9p24.3, 11q22.3, 15q11.2, 16q24.1 and Xq21.31 by Barnekow, Elin, Hasslow, Johan, Liu, Wen, Bryant, Patrick, Thutkawkorapin, Jessada, Wendt, Camilla, Czene, Kamila, Hall, Per, Margolin, Sara, Lindblom, Annika

“…Most breast cancer heritability is unexplained. We hypothesized that analysis of unrelated familial cases in a GWAS context could enable the identification of…”
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Evaluation of measles IgM antibody detection assays during the 2018-2019 outbreak in New York State by Carson, Kyle J., Tucker, Heidi R., Howard, Kelly, Hales, Margaux, Bryant, Patrick W., St. George, Kirsten, Kulas, Karen E., Lee, William T.

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Accumulation of oxidized proteins in Herpesvirus infected cells by Mathew, Shomita S., Bryant, Patrick W., Burch, April D.

“…Oxidative stress gives rise to an environment that can be highly damaging to proteins, lipids, and DNA. Previous studies indicate that Herpesvirus infections…”
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Recurrent, low-frequency coding variants contributing to colorectal cancer in the Swedish population by Jiao, Xiang, Liu, Wen, Mahdessian, Hovsep, Bryant, Patrick, Ringdahl, Jenny, Timofeeva, Maria, Farrington, Susan M, Dunlop, Malcolm, Lindblom, Annika

“…Genome-wide association studies (GWAS) have identified dozens of common genetic variants associated with risk of colorectal cancer (CRC). However, the majority…”
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Genetic characterization of mumps viruses associated with the resurgence of mumps in the United States: 2015–2017 by McNall, Rebecca J., Wharton, Adam K., Anderson, Raydel, Clemmons, Nakia, Lopareva, Elena N., Gonzalez, Carlos, Espinosa, Alex, Probert, William S., Hacker, Jill K., Liu, Gongping, Garfin, Jacob, Strain, Anna K., Boxrud, David, Bryant, Patrick W., George, Kirsten St, Davis, Timothy, Griesser, Richard H., Shult, Peter, Bankamp, Bettina, Hickman, Carole J., Wroblewski, Kelly, Rota, Paul A

“…•From 2015–2017 greater than 13,800 cases of mumps were reported in the United States.•In 2013, the CDC and the Association of Public Health Laboratories…”
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Deep learning for protein complex structure prediction by Bryant, Patrick

“…Recent developments in the structure prediction of protein complexes have resulted in accuracies rivalling experimental methods in many cases. The high…”
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Focal Adhesion Kinase Controls Cellular Levels of p27/Kip1 and p21/Cip1 through Skp2-Dependent and -Independent Mechanisms by Bryant, Patrick, Zheng, Qingxia, Pumiglia, Kevin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Vascular Endothelial Growth Factor Induction of the Angiogenic Phenotype Requires Ras Activation by Meadows, Kafi N., Bryant, Patrick, Pumiglia, Kevin

“…We investigated the role of Ras in vascular endothelial growth factor (VEGF)-mediated signal transduction and the promotion of angiogenic changes primary…”
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Activation of p38 Has Opposing Effects on the Proliferation and Migration of Endothelial Cells by McMullen, Meghan E., Bryant, Patrick W., Glembotski, Christopher C., Vincent, Peter A., Pumiglia, Kevin M.

“…Pathological conditions such as hypertension and hyperglycemia as well as abrasions following balloon angioplasty all lead to endothelial dysfunction that…”
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Diagnosis of acute deer tick virus encephalitis by El Khoury, Marc Y, Hull, Rene C, Bryant, Patrick W, Escuyer, Kay L, St George, Kirsten, Wong, Susan J, Nagaraja, Aarathi, Kramer, Laura, Dupuis, Alan P, Purohit, Treta, Shah, Tushar, Wormser, Gary P

“…Deer tick virus (DTV) is a tick-borne flavivirus that has only recently been appreciated as a cause of viral encephalitis. We describe the clinical…”
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