Search Results - "Bryant, K Dawn"

INX-08189, a Phosphoramidate Prodrug of 6-O-Methyl-2′-C-Methyl Guanosine, Is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic and Pharmacodynamic Properties by Vernachio, John H, Bleiman, Blair, Bryant, K Dawn, Chamberlain, Stanley, Hunley, Damound, Hutchins, Jeff, Ames, Brenda, Gorovits, Elena, Ganguly, Babita, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, C Robin, Wang, Jin, Williams, Karen, Patti, Joseph M, Henson, Geoffrey, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, McGuigan, Christopher

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Phosphorodiamidates as a Promising New Phosphate Prodrug Motif for Antiviral Drug Discovery: Application to Anti-HCV Agents by McGuigan, Christopher, Madela, Karolina, Aljarah, Mohamed, Bourdin, Claire, Arrica, Maria, Barrett, Emma, Jones, Sarah, Kolykhalov, Alexander, Bleiman, Blair, Bryant, K. Dawn, Ganguly, Babita, Gorovits, Elena, Henson, Geoffrey, Hunley, Damound, Hutchins, Jeff, Muhammad, Jerry, Obikhod, Aleksandr, Patti, Joseph, Walters, C. Robin, Wang, Jin, Vernachio, John, Ramamurty, Changalvala V. S, Battina, Srinivas K, Chamberlain, Stanley

“…We herein report phosphorodiamidates as a significant new phosphate prodrug motif. Sixty-seven phosphorodiamidates are reported of two 6-O-alkyl 2′-C-methyl…”
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Phosphoramidate ProTides of 2′-C-Methylguanosine as Highly Potent Inhibitors of Hepatitis C Virus. Study of Their in Vitro and in Vivo Properties by McGuigan, Christopher, Gilles, Arnaud, Madela, Karolina, Aljarah, Mohamed, Holl, Sabrina, Jones, Sarah, Vernachio, John, Hutchins, Jeff, Ames, Brenda, Bryant, K. Dawn, Gorovits, Elena, Ganguly, Babita, Hunley, Damound, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, Robin, Wang, Jin, Chamberlain, Stanley, Henson, Geoffrey

“…Hepatitis C virus infection constitutes a serious health problem in need of more effective therapies. Nucleoside analogues with improved exposure, efficacy,…”
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Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2′-C-methyl-6-O-methyl guanosine nucleoside and l-Alanine ester phosphoramidates by Bourdin, Claire, McGuigan, Christopher, Brancale, Andrea, Chamberlain, Stanley, Vernachio, John, Hutchins, Jeff, Gorovits, Elena, Kolykhalov, Alexander, Muhammad, Jerry, Patti, Joseph, Henson, Geoffrey, Bleiman, Blair, Bryant, K. Dawn, Ganguly, Babita, Hunley, Damound, Obikhod, Aleksandr, Walters, C. Robin, Wang, Jin, Ramamurty, Changalvala V.S., Battina, Srinivas K., Srivinas Rao, C.

“…7-Deazapurines are known to possess broad antiviral activity, however the 2′-C-methylguanosine analogue displays poor cell permeation and limited…”
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