Search Results - "Bryant, Clare E."

Phagocytosis Dynamics Depends on Target Shape by Paul, Debjani, Achouri, Sarra, Yoon, Young-Zoon, Herre, Jurgen, Bryant, Clare E., Cicuta, Pietro

“…A complete understanding of phagocytosis requires insight into both its biochemical and physical aspects. One of the ways to explore the physical mechanism of…”
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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages by Mills, Evanna L., Kelly, Beth, Logan, Angela, Costa, Ana S.H., Varma, Mukund, Bryant, Clare E., Tourlomousis, Panagiotis, Däbritz, J. Henry M., Gottlieb, Eyal, Latorre, Isabel, Corr, Sinéad C., McManus, Gavin, Ryan, Dylan, Jacobs, Howard T., Szibor, Marten, Xavier, Ramnik J., Braun, Thomas, Frezza, Christian, Murphy, Michael P., O’Neill, Luke A.

“…Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory phenotype, but the mechanistic basis for this remains obscure. Here,…”
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Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages by Gram, Anna M, Wright, John A, Pickering, Robert J, Lam, Nathaniel L, Booty, Lee M, Webster, Steve J, Bryant, Clare E

“…Infection of human macrophages with serovar Typhimurium ( Typhimurium) leads to inflammasome activation. Inflammasomes are multiprotein complexes facilitating…”
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The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system by Moshayedi, Pouria, Ng, Gilbert, Kwok, Jessica C.F, Yeo, Giles S.H, Bryant, Clare E, Fawcett, James W, Franze, Kristian, Guck, Jochen

“…Abstract Devices implanted into the body become encapsulated due to a foreign body reaction. In the central nervous system (CNS), this can lead to loss of…”
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Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex by Man, Si Ming, Hopkins, Lee J., Nugent, Eileen, Cox, Susan, Glück, Ivo M., Tourlomousis, Panagiotis, Wright, John A., Cicuta, Pietro, Monie, Tom P., Bryant, Clare E.

“…Pathogen recognition by nucleotide-binding oligomerization domain-like receptor (NLR) results in the formation of a macromolecular protein complex…”
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Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88 by Sakai, Jiro, Cammarota, Eugenia, Wright, John A., Cicuta, Pietro, Gottschalk, Rachel A., Li, Ning, Fraser, Iain D. C., Bryant, Clare E.

“…TLR4 signalling through the MyD88 and TRIF-dependent pathways initiates translocation of the transcription factor NF-κB into the nucleus. In cell population…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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The molecular basis of the host response to lipopolysaccharide by Bryant, Clare E, Spring, David R, Gangloff, Monique, Gay, Nicholas J

“…Lipopolysaccharide (LPS) from Gram-negative bacteria is a potent activator of the innate immune response. Clare Bryant and colleagues discuss recent exciting…”
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Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer by O'Neill, Luke A J, Bryant, Clare E, Doyle, Sarah L

“…Since first being described in the fruit fly Drosophila melanogaster , Toll-like receptors (TLRs) have proven to be of great interest to immunologists and…”
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MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling by Moncrieffe, Martin C., Bollschweiler, Daniel, Li, Bing, Penczek, Pawel A., Hopkins, Lee, Bryant, Clare E., Klenerman, David, Gay, Nicholas J.

“…Toll-like receptors (TLRs) are pivotal in triggering the innate immune response to pathogen infection. Ligand binding induces receptor dimerization which…”
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A Comprehensive UHPLC Ion Mobility Quadrupole Time-of-Flight Method for Profiling and Quantification of Eicosanoids, Other Oxylipins, and Fatty Acids by Hinz, Christine, Liggi, Sonia, Mocciaro, Gabriele, Jung, Stephanie, Induruwa, Isuru, Pereira, Milton, Bryant, Clare E, Meckelmann, Sven W, O’Donnell, Valerie B, Farndale, Richard W, Fjeldsted, John, Griffin, Julian L

“…Analysis of oxylipins by liquid chromatography mass spectrometry (LC/MS) is challenging because of the small mass range occupied by this diverse lipid class,…”
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Actin polymerization as a key innate immune effector mechanism to control Salmonella infection by Man, Si Ming, Ekpenyong, Andrew, Tourlomousis, Panagiotis, Achouri, Sarra, Cammarota, Eugenia, Hughes, Katherine, Rizzo, Alessandro, Ng, Gilbert, Wright, John A., Cicuta, Pietro, Guck, Jochen R., Bryant, Clare E.

“…Significance Infectious diseases are responsible for one-third of all mortality worldwide. Innate immunity is critical for mounting host defenses that…”
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Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen by Onyishi, Chinaemerem U., Desanti, Guillaume E., Wilkinson, Alex L., Lara-Reyna, Samuel, Frickel, Eva-Maria, Fejer, Gyorgy, Christophe, Olivier D., Bryant, Clare E., Mukhopadhyay, Subhankar, Gordon, Siamon, May, Robin C.

“…The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response…”
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Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses by Meng, Jonathan X., Zhang, Yu, Saman, Dominik, Haider, Arshad M., De, Suman, Sang, Jason C., Brown, Karen, Jiang, Kun, Humphrey, Jane, Julian, Linda, Hidari, Eric, Lee, Steven F., Balmus, Gabriel, Floto, R. Andres, Bryant, Clare E., Benesch, Justin L. P., Ye, Yu, Klenerman, David

“…Soluble aggregates of the microtubule-associated protein tau have been challenging to assemble and characterize, despite their important role in the…”
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Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub by Latty, Sarah Louise, Sakai, Jiro, Hopkins, Lee, Verstak, Brett, Paramo, Teresa, Berglund, Nils A, Cammarota, Eugenia, Cicuta, Pietro, Gay, Nicholas J, Bond, Peter J, Klenerman, David, Bryant, Clare E

“…Infection and tissue damage induces assembly of supramolecular organizing centres (SMOCs)), such as the Toll-like receptor (TLR) MyDDosome, to co-ordinate…”
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Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization by Liu, Yangci, Zhai, Haoming, Alemayehu, Helen, Boulanger, Jérôme, Hopkins, Lee J., Borgeaud, Alicia C., Heroven, Christina, Howe, Jonathan D., Leigh, Kendra E., Bryant, Clare E., Modis, Yorgo

“…NLRP3 induces caspase-1-dependent pyroptotic cell death to drive inflammation. Aberrant activity of NLRP3 occurs in many human diseases. NLRP3 activation…”
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The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide by Li, Bing, Suresh, Prasanna, Brelstaff, Jack, Kedia, Shekhar, Bryant, Clare E, Klenerman, David

“…The Myddosome is a key innate immune signalling platform. It forms at the cell surface and contains MyD88 and IRAK proteins which ultimately coordinate the…”
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The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane by Liaunardy-Jopeace, Ardiyanto, Bryant, Clare E, Gay, Nicholas J

“…Toll-like receptor 4 (TLR4), the receptor for the bacterial product endotoxin, is subject to multiple points of regulation at the levels of signaling,…”
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Naturally-occurring serotype 3 Streptococcus pneumoniae strains that lack functional pneumolysin and autolysin have attenuated virulence but induce localized protective immune responses by Wong, Ηαnnah E, Tourlomousis, Panagiotis, Paterson, Gavin K, Webster, Steve, Bryant, Clare E

“…Streptococcus pneumoniae is an important cause of fatal pneumonia in humans. These bacteria express virulence factors, such as the toxins pneumolysin and…”
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Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting by Pereira, Milton, Liang, Jonathan, Edwards-Hicks, Joy, Meadows, Allison M., Hinz, Christine, Liggi, Sonia, Hepprich, Matthias, Mudry, Jonathan M., Han, Kim, Griffin, Julian L., Fraser, Iain, Sack, Michael N., Hess, Christoph, Bryant, Clare E.

“…Elevated interleukin (IL)-1β levels, NLRP3 inflammasome activity, and systemic inflammation are hallmarks of chronic metabolic inflammatory syndromes, but the…”
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