Search Results - "Bryant, Alexander P."

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit by Busby, Robert W., Bryant, Alexander P., Bartolini, Wilmin P., Cordero, Etchell A., Hannig, Gerhard, Kessler, Marco M., Mahajan-Miklos, Shalina, Pierce, Christine M., Solinga, Robert M., Sun, Li Jing, Tobin, Jenny V., Kurtz, Caroline B., Currie, Mark G.

“…Linaclotide is a first-in-class, orally administered 14-amino acid peptide that is in development for the treatment of irritable bowel syndrome with…”
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Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain by Hannig, Gerhard, Tchernychev, Boris, Kurtz, Caroline B, Bryant, Alexander P, Currie, Mark G, Silos-Santiago, Inmaculada

“…Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist…”
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Inhibition of Filamentation Can Be Used To Treat Disseminated Candidiasis by SAVILLE, Stephen P, LAZZELL, Anna L, BRYANT, Alexander P, FRETZEN, Angelika, MONREAL, Alex, SOLBERG, Erik O, MONTEAGUDO, Carlos, LOPEZ-RIBOT, Jose L, MILNE, G. Todd

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A genomic analysis of two‐component signal transduction in Streptococcus pneumoniae by Throup, John P., Koretke, Kristin K., Bryant, Alexander P., Ingraham, Karen A., Chalker, Alison F., Ge, Yigong, Marra, Andrea, Wallis, Nicola G., Brown, James R., Holmes, David J., Rosenberg, Martin, Burnham, Martin K. R.

“…A genomics‐based approach was used to identify the entire gene complement of putative two‐component signal transduction systems (TCSTSs) in Streptococcus…”
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Identification, Evolution, and Essentiality of the Mevalonate Pathway for Isopentenyl Diphosphate Biosynthesis in Gram-Positive Cocci by Wilding, E I, Brown, J R, Bryant, A P, Chalker, A F, Holmes, D J, Ingraham, K A, Iordanescu, S, So, C Y, Rosenberg, M, Gwynn, M N

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation by Busby, Robert W, Kessler, Marco M, Bartolini, Wilmin P, Bryant, Alexander P, Hannig, Gerhard, Higgins, Carolyn S, Solinga, Robert M, Tobin, Jenny V, Wakefield, James D, Kurtz, Caroline B, Currie, Mark G

“…Linaclotide, a potent guanylate cyclase C agonist, is a therapeutic peptide approved in the United States for the treatment of irritable bowel syndrome with…”
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The srhSR Gene Pair from Staphylococcus aureus:  Genomic and Proteomic Approaches to the Identification and Characterization of Gene Function by Throup, John P, Zappacosta, Francesca, Lunsford, R. Dwayne, Annan, Roland S, Carr, Steven A, Lonsdale, John T, Bryant, Alexander P, McDevitt, Damien, Rosenberg, Martin, Burnham, Martin K. R

“…Systematic analysis of the entire two-component signal transduction system (TCSTS) gene complement of Staphylococcus aureus revealed the presence of a putative…”
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Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract by Bryant, Alexander P., Busby, Robert W., Bartolini, Wilmin P., Cordero, Etchell A., Hannig, Gerhard, Kessler, Marco M., Pierce, Christine M., Solinga, Robert M., Tobin, Jenny V., Mahajan-Miklos, Shalina, Cohen, Mitchell B., Kurtz, Caroline B., Currie, Mark G.

“…Linaclotide is an orally administered 14-amino acid peptide being developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and…”
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MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux by Tchernychev, Boris, Ge, Pei, Kessler, Marco M, Solinga, Robert M, Wachtel, Derek, Tobin, Jenny V, Thomas, Sara R, Lunte, Craig E, Fretzen, Angelika, Hannig, Gerhard, Bryant, Alexander P, Kurtz, Caroline B, Currie, Mark G, Silos-Santiago, Inmaculada

“…MRP4 mediates the efflux of cGMP and cAMP and acts as an important regulator of these secondary messengers, thereby affecting signaling events mediated by cGMP…”
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Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation by Silos-Santiago, Inmaculada, Hannig, Gerhard, Eutamene, Helene, Ustinova, Elena E., Bernier, Sylvie G., Ge, Pei, Graul, Christopher, Jacobson, Sarah, Jin, Hong, Liong, Elaine, Kessler, Marco M., Reza, Tammi, Rivers, Samuel, Shea, Courtney, Tchernychev, Boris, Bryant, Alexander P., Kurtz, Caroline B., Bueno, Lionel, Pezzone, Michael A., Currie, Mark G.

“…Uroguanylin activation of the guanylate cyclase-C/cyclic guanosine monophosphate pathway elicits analgesic effects in animal models of colonic…”
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Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus by Wilding, E I, Kim, D Y, Bryant, A P, Gwynn, M N, Lunsford, R D, McDevitt, D, Myers, Jr, J E, Rosenberg, M, Sylvester, D, Stauffacher, C V, Rodwell, V W

“…Sequence comparisons have implied the presence of genes encoding enzymes of the mevalonate pathway for isopentenyl diphosphate biosynthesis in the…”
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rho is not essential for viability or virulence in Staphylococcus aureus by WASHBURN, Robert S, MARRA, Andrea, BRYANT, Alexander P, ROSENBERG, Martin, GENTRY, Daniel R

“…We have identified the gene for transcription termination factor Rho in Staphylococcus aureus. Deletion of rho in S. aureus reveals that it is not essential…”
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The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence by Chalker, Alison F, Ingraham, Karen A, Lunsford, R. Dwayne, Bryant, Alexander P, Bryant, Joanna, Wallis, Nicola G, Broskey, John P, Pearson, Stewart C, Holmes, David J

“…Anti-Infective Research (UP1345), SmithKline Beecham Pharmaceuticals, 1250 South Collegeville Road, PO Box 5089, Collegeville, PA19426-0989, USA 1 Author for…”
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Sa1213 THE BILE ACID SEQUESTRANT COLESEVELAM AMELIORATES BILE ACID-DELAYED GASTRIC EMPTYING AND SLOWED SMALL INTESTINAL TRANSIT IN MICE by Kessler, Marco, Smith, Adaline C., Bryant, Alexander P.

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Sa1212 THE G-PROTEIN-COUPLED BILE ACID RECEPTOR TGR5 (GPBAR1) IS EXPRESSED IN BOTH MUCOSA AND MUSCLE TISSUE FROM HUMAN LOWER ESOPHAGEAL SPHINCTER (LES) by Kessler, Marco, Smith, Adaline C., Bryant, Alexander P.

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Characterization of the Streptococcus pneumoniae NADH oxidase that is required for infection by Yu, Jun, Bryant, Alexander P, Marra, Andrea, Lonetto, Michael A, Ingraham, Karen A, Chalker, Alison F, Holmes, David J, Holden, David, Rosenberg, Martin, McDevitt, Damien

“…Anti-Infectives Research, SmithKline Beecham Pharmaceuticals Research and Development, 1250 S. Collegeville Road, Collegeville, PA 19426, USA 1 Department of…”
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rho Is Not Essential for Viability or Virulence inStaphylococcus aureus by Washburn, Robert S, Marra, Andrea, Bryant, Alexander P, Rosenberg, Martin, Gentry, Daniel R

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A functional genomic analysis of type 3 Streptococcus pneumoniae virulence by Lau, Gee W., Haataja, Sauli, Lonetto, Michael, Kensit, Sarah E., Marra, Andrea, Bryant, Alexander P., McDevitt, Damien, Morrison, Donald A., Holden, David W.

“…Streptococcus pneumoniae remains a serious cause of morbidity and mortality in humans, but relatively little is known about the molecular basis of its…”
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Linaclotide Significantly Improves Post-Operative Ileus and Opiate-Induced Constipation in Rats: 1257 by Bryant, Alexander P., Cordero, Etchell A., Tobin, Jenny V., Rivers, Samuel, Kurtz, Caroline B., Currie, Mark G.

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ANTINOCICEPTIVE ACTIONS OF MD-1100, A NOVEL THERAPEUTIC AGENT FOR c-IBS, IN ANIMAL MODELS OF VISCERAL PAIN: 867 by Bueno, Lionel, Beaufrand, Catherine, Mahajan-Miklos, Shalina, Bryant, Alexander P., Currie, Mark G.

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