Search Results - "Bryan‐Lluka, Lesley J."

A Role for Serotonin (5-HT) in Hepatic Stellate Cell Function and Liver Fibrosis by Ruddell, Richard G., Oakley, Fiona, Hussain, Ziafat, Yeung, Irene, Bryan-Lluka, Lesley J., Ramm, Grant A., Mann, Derek A.

“…Hepatic stellate cells (HSCs) are key cellular components of hepatic wound healing and fibrosis. There is emerging evidence that the fibrogenic function of…”
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Roles of transmembrane domain 2 and the first intracellular loop in human noradrenaline transporter function: pharmacological and SCAM analysis by Sucic, Sonja, Bryan‐Lluka, Lesley J.

“…The aim was to investigate the roles of transmembrane domain 2 and the adjacent region of the first intracellular loop in determining human noradrenaline…”
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Nitric oxide donors inhibit 5‐hydroxytryptamine (5‐HT) uptake by the human 5‐HT transporter (SERT) by Bryan‐Lluka, Lesley J, Papacostas, Marisa H, Paczkowski, Filip A, Wanstall, Janet C

“…The aim was to test the hypothesis that nitric oxide (NO) donor drugs can inhibit the 5‐hydroxytryptamine (5‐HT) transporter, SERT. The NO donors, MAHMA/NO (a…”
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Extracellular loop 3 of the noradrenaline transporter contributes to substrate and inhibitor selectivity by Lynagh, Timothy, Khamu, Tina S., Bryan-Lluka, Lesley J.

“…The human noradrenaline transporter (NET) and 5-hydroxytryptamine (5-HT) transporter (SERT) are inhibited by antidepressants and psychoactive drugs such as…”
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Functional significance of a highly conserved glutamate residue of the human noradrenaline transporter by Sucic, Sonja, Paczkowski, Filip A., Runkel, Fabian, Bönisch, Heinz, Bryan‐Lluka, Lesley J.

“…The aim of the study was to investigate the role of glutamate residue 113 in transmembrane domain 2 of the human noradrenaline transporter in determining cell…”
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Investigation of the functional roles of the MELAL and GQXXRXG motifs of the human noradrenaline transporter using cysteine mutants by Sucic, Sonja, Bryan-Lluka, Lesley J.

“…The study examines the roles of the highly conserved MELAL and GQXXRXG motifs, located in the second transmembrane domain and the first intracellular loop of…”
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Dose determination of haloperidol, risperidone and olanzapine using an in vivo dopamine D2-receptor occupancy method in the rat by NAIKER, Dineshree V, CARTS, Stanley V, CATTS, Vibeke S, BEDI, Kuldip S, BRYAN-LLUKA, Lesley J

“…The purpose of the present study was to determine antipsychotic doses that achieve 80% striatal dopamine D2-receptor occupancy for haloperidol, risperidone and…”
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χ-Conopeptide MrIA Partially Overlaps Desipramine and Cocaine Binding Sites on the Human Norepinephrine Transporter by Bryan-Lluka, Lesley J., Bönisch, Heinz, Lewis, Richard J.

“…The interactions of χ-conopeptide MrIA with the human norepinephrine transporter (hNET) were investigated by determining the effects of hNET point mutations on…”
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Quantitative analysis of immunolabeling for serotonin and for glutamate transporters after administration of imipramine and citalopram by Williams, Susan M., Bryan-Lluka, Lesley J., Pow, David V.

“…Serotonin (5-hydroxytryptamine, 5-HT) is an amine neurotransmitter derived from tryptophan and is important in brain systems regulating mood, emotional…”
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Comparison of the pharmacological properties of cloned rat, human, and bovine norepinephrine transporters by Paczkowski, F A, Bryan-Lluka, L J, Pörzgen, P, Brüss, M, Bönisch, H

“…The aims of this study were to characterize the recently cloned rat norepinephrine transporter (NET) in more detail and in particular to study possible species…”
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Effects of short- and long-term exposure to c-AMP and c-GMP on the noradrenaline transporter by Bryan-Lluka, Lesley J., Paczkowski, Filip A., Bönisch, Heinz

“…The effects of short- and long-term exposure of cells to elevated cyclic adenosine monophosphate (c-AMP), using dibutyryl-c-AMP, 8-bromo-c-AMP, cholera toxin…”
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Amino acids involved in differences in the pharmacological profiles of the rat and human noradrenaline transporters by Paczkowski, Filip A, Bryan-Lluka, Lesley J

“…It has been suggested from a previous study in our laboratory that differences in the pharmacology of the species variants of the noradrenaline transporter…”
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Specific uptake of 5-hydroxytryptamine is reduced in lungs from hypoxic pulmonary hypertensive rats by Jeffery, Trina K, Bryan-Lluka, Lesley J, Wanstall, Janet C

“…In this study, the aim was to determine whether 5-hydroxytryptamine (5-HT) removal by the pulmonary endothelium is reduced in 1-week hypoxic, pulmonary…”
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5-Hydroxytryptamine and platelets: uptake and aggregation in hypoxic pulmonary hypertensive rats by Awabdy, Doreen, Bryan-Lluka, Lesley J., Wanstall, Janet C.

“…Pulmonary hypertension is associated with various alterations in 5-hydroxytryptamine (5-HT) physiology. In this study in platelets from hypoxic pulmonary…”
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The role of the conserved GXXXRXG motif in the expression and function of the human norepinephrine transporter by Sucic, Sonja, Bryan-Lluka, Lesley J

“…Highly conserved motifs in the monoamine transporters, e.g. the human norepinephrine transporter (hNET) GXXXRXG motif which was the focus of the present study,…”
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Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology by Paczkowski, Filip A, Bryan-Lluka, Lesley J

“…The aim was to examine the functional importance in the norepinephrine transporter (NET) of (i) the phenylalanine residue at position 531 in transmembrane…”
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The rat norepinephrine transporter: molecular cloning from PC12 cells and functional expression by Bruss, M, Porzgen, P, Bryan-Lluka, L J, Bonisch, H

“…The rat norepinephrine transporter (rNET) cDNA from the PC12 pheochromocytoma cell line has been cloned by RT-PCR and characterized. The cDNA encodes an…”
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Dose determination of haloperidol, risperidone and olanzapine using an in vivo dopamine D 2-receptor occupancy method in the rat by Naiker, Dineshree V., Catts, Stanley V., Catts, Vibeke S., Bedi, Kuldip S., Bryan-Lluka, Lesley J.

“…The purpose of the present study was to determine antipsychotic doses that achieve 80% striatal dopamine D 2-receptor occupancy for haloperidol, risperidone…”
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Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter by Paczkowski, Filip A, Bönisch, Heinz, Bryan-Lluka, Lesley J

“…Recently, another research group has reported an almost complete loss of function of the human norepinephrine transporter (hNET) in patients who had…”
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Neurotransmitter Transporters: Structure, Function and Regulation by Bryan-Lluka, Lesley J

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