Search Results - "Bryan, Kenneth"

Using biological networks to integrate, visualize and analyze genomics data by Charitou, Theodosia, Bryan, Kenneth, Lynn, David J

“…Network biology is a rapidly developing area of biomedical research and reflects the current view that complex phenotypes, such as disease susceptibility, are…”
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A comparative analysis of the transcriptome profiles of liver and muscle tissue in pigs divergent for feed efficiency by Vigors, Stafford, O'Doherty, John V, Bryan, Kenneth, Sweeney, Torres

“…The improvement of feed efficiency is a key economic goal within the pig production industry. The objective of this study was to examine transcriptomic…”
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Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy by Miller-Delaney, Suzanne F C, Bryan, Kenneth, Das, Sudipto, McKiernan, Ross C, Bray, Isabella M, Reynolds, James P, Gwinn, Ryder, Stallings, Raymond L, Henshall, David C

“…Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene expression in the hippocampus. Epigenetic changes to DNA are attractive…”
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MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2 by Foley, Niamh H, Bray, Isabella M, Tivnan, Amanda, Bryan, Kenneth, Murphy, Derek M, Buckley, Patrick G, Ryan, Jacqueline, O'Meara, Anne, O'Sullivan, Maureen, Stallings, Raymond L

“…Neuroblastoma is a paediatric cancer of the sympathetic nervous system. The single most important genetic indicator of poor clinical outcome is amplification…”
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MiR‐137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A by Althoff, Kristina, Beckers, Anneleen, Odersky, Andrea, Mestdagh, Pieter, Köster, Johannes, Bray, Isabella M., Bryan, Kenneth, Vandesompele, Jo, Speleman, Frank, Stallings, Raymond L., Schramm, Alexander, Eggert, Angelika, Sprüssel, Annika, Schulte, Johannes H.

“…Neuroblastoma is the most common extracranial solid tumor of childhood, and accounts for ∼15% of all childhood cancer deaths. The histone demethylase,…”
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miRNA profiles as a predictor of chemoresponsiveness in Wilms' tumor blastema by Watson, Jenny A, Bryan, Kenneth, Williams, Richard, Popov, Sergey, Vujanic, Gordan, Coulomb, Aurore, Boccon-Gibod, Liliane, Graf, Norbert, Pritchard-Jones, Kathy, O'Sullivan, Maureen

“…The current SIOP treatment protocol for Wilms' tumor involves pre-operative chemotherapy followed by nephrectomy. Not all patients benefit equally from such…”
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MicroRNA mediates DNA demethylation events triggered by retinoic acid during neuroblastoma cell differentiation by Das, Sudipto, Foley, Niamh, Bryan, Kenneth, Watters, Karen M, Bray, Isabella, Murphy, Derek M, Buckley, Patrick G, Stallings, Raymond L

“…Neuroblastoma is an often fatal pediatric cancer arising from precursor cells of the sympathetic nervous system. 13-Cis retinoic acid is included in the…”
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Equine skeletal muscle adaptations to exercise and training: evidence of differential regulation of autophagosomal and mitochondrial components by Bryan, Kenneth, McGivney, Beatrice A, Farries, Gabriella, McGettigan, Paul A, McGivney, Charlotte L, Gough, Katie F, MacHugh, David E, Katz, Lisa M, Hill, Emmeline W

“…A single bout of exercise induces changes in gene expression in skeletal muscle. Regular exercise results in an adaptive response involving changes in muscle…”
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First report of Acanthamoebae spp. isolation from a volcanic mud spring in the Philippines by Celis, Crisselle Marie, Caburnay, Isabella Marie, Avila, Fritz Irish, Conol, Hannah Mica, Cuevas, Aleli, Cunan, Maria Angela, Blanco, J Piolo, Banal, Kenneth Bryan, Hapan, Ma. Frieda Z., Manahan, Edilberto P., Padua, Mark F. F. E., Masangkay, Frederick R., Milanez, Giovanni D. Jesus

“…Abstract Acanthamoebae spp. is considered highly adaptive. The present study aims to establish the occurrence of free-living amoebae, particularly…”
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Discovery and visualization of miRNA-mRNA functional modules within integrated data using bicluster analysis by Bryan, Kenneth, Terrile, Marta, Bray, Isabella M, Domingo-Fernandéz, Raquel, Watters, Karen M, Koster, Jan, Versteeg, Rogier, Stallings, Raymond L

“…MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at a post-transcriptional level. An miRNA may target many messenger RNA…”
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Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival by Bray, Isabella, Bryan, Kenneth, Prenter, Suzanne, Buckley, Patrick G, Foley, Niamh H, Murphy, Derek M, Alcock, Leah, Mestdagh, Pieter, Vandesompele, Jo, Speleman, Frank, London, Wendy B, McGrady, Patrick W, Higgins, Desmond G, O'Meara, Anne, O'Sullivan, Maureen, Stallings, Raymond L

“…MiRNAs regulate gene expression at a post-transcriptional level and their dysregulation can play major roles in the pathogenesis of many different forms of…”
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Identifying Patients with Polycythemia Vera at Risk of Thrombosis after Hydroxyurea Initiation: The Polycythemia Vera-Advanced Integrated Models (PV-AIM) Project by Verstovsek, Srdan, Krečak, Ivan, Heidel, Florian H, De Stefano, Valerio, Bryan, Kenneth, Zuurman, Mike W, Zaiac, Michael, Morelli, Mara, Smyth, Aoife, Redondo, Santiago, Bigan, Erwan, Ruhl, Michael, Meier, Christoph, Beffy, Magali, Kiladjian, Jean-Jacques

“…Patients with polycythemia vera (PV) are at significant risk of thromboembolic events (TE). The PV-AIM study used the Optum de-identified Electronic Health…”
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Chromosomal and MicroRNA Expression Patterns Reveal Biologically Distinct Subgroups of 11q- Neuroblastoma by BUCKLEY, Patrick G, ALCOCK, Leah, SPELEMAN, Frank, STALLINGS, Raymond L, BRYAN, Kenneth, BRAY, Isabella, SCHULTE, Johannes H, SCHRAMM, Alexander, EGGERT, Angelika, MESTDAGH, Pieter, DE PRETER, Katleen, VANDESOMPELE, Jo

“…The purpose of this study was to further define the biology of the 11q- neuroblastoma tumor subgroup by the integration of array-based comparative genomic…”
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Expression Quantitative Trait Loci in Equine Skeletal Muscle Reveals Heritable Variation in Metabolism and the Training Responsive Transcriptome by Farries, Gabriella, Bryan, Kenneth, McGivney, Charlotte L, McGettigan, Paul A, Gough, Katie F, Browne, John A, MacHugh, David E, Katz, Lisa Michelle, Hill, Emmeline W

“…While over ten thousand genetic loci have been associated with phenotypic traits and inherited diseases in genome-wide association studies, in most cases only…”
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MicroRNA profiling of the bovine alveolar macrophage response to Mycobacterium bovis infection suggests pathogen survival is enhanced by microRNA regulation of endocytosis and lysosome trafficking by Vegh, Peter, Magee, David A, Nalpas, Nicolas C, Bryan, Kenneth, McCabe, Matthew S, Browne, John A, Conlon, Kevin M, Gordon, Stephen V, Bradley, Daniel G, MacHugh, David E, Lynn, David J

“…Summary Mycobacterium bovis , the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up…”
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MetaFIND: a feature analysis tool for metabolomics data by Bryan, Kenneth, Brennan, Lorraine, Cunningham, Pádraig

“…Metabolomics, or metabonomics, refers to the quantitative analysis of all metabolites present within a biological sample and is generally carried out using NMR…”
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miRNA expression profiling of the murine TH-MYCN neuroblastoma model reveals similarities with human tumors and identifies novel candidate miRNAs by Terrile, Marta, Bryan, Kenneth, Vaughan, Lynsey, Hallsworth, Albert, Webber, Hannah, Chesler, Louis, Stallings, Raymond L

“…MicroRNAs are small molecules which regulate gene expression post-transcriptionally and aberrant expression of several miRNAs is associated with neuroblastoma,…”
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Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation by Murphy, Derek M, Buckley, Patrick G, Bryan, Kenneth, Das, Sudipto, Alcock, Leah, Foley, Niamh H, Prenter, Suzanne, Bray, Isabella, Watters, Karen M, Higgins, Desmond, Stallings, Raymond L

“…Neuroblastoma, a cancer derived from precursor cells of the sympathetic nervous system, is a major cause of childhood cancer related deaths. The single most…”
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Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST] by Kelly, Lorna, Bryan, Kenneth, Kim, Su Young, Janeway, Katherine A, Killian, J Keith, Schildhaus, Hans-Ulrich, Miettinen, Markku, Helman, Lee, Meltzer, Paul S, van de Rijn, Matt, Debiec-Rychter, Maria, O'Sullivan, Maureen

“…In contrast to adult mutant gastrointestinal stromal tumors [GISTs], pediatric/wild-type GISTs remain poorly understood overall, given their lack of oncogenic…”
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Genome‐wide DNA methylation analysis of neuroblastic tumors reveals clinically relevant epigenetic events and large‐scale epigenomic alterations localized to telomeric regions by Buckley, Patrick G., Das, Sudipto, Bryan, Kenneth, Watters, Karen M., Alcock, Leah, Koster, Jan, Versteeg, Rogier, Stallings, Raymond L.

“…The downregulation of specific genes through DNA hypermethylation is a major hallmark of cancer, although the extent and genomic distribution of…”
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