Search Results - "Bryan, Brad A."

RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis by Bryan, Brad A, Dennstedt, Emily, Mitchell, Dianne C, Walshe, Tony E, Noma, Kensuke, Loureiro, Robyn, Saint-Geniez, Magali, Campaigniac, Jean-Paul, Liao, James K, D'Amore, Patricia A

“…The small GTPase RhoA and its downstream effectors, ROCK1 and ROCK2, regulate a number of cellular processes, including cell motility, proliferation, survival,…”
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Targeting of beta adrenergic receptors results in therapeutic efficacy against models of hemangioendothelioma and angiosarcoma by Stiles, Jessica M, Amaya, Clarissa, Rains, Steven, Diaz, Dolores, Pham, Robert, Battiste, James, Modiano, Jaime F, Kokta, Victor, Boucheron, Laura E, Mitchell, Dianne C, Bryan, Brad A

“…Therapeutic targeting of the beta-adrenergic receptors has recently shown remarkable efficacy in the treatment of benign vascular tumors such as infantile…”
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Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux by Saha, Jhuma, Kim, Jong Hyuk, Amaya, Clarissa N, Witcher, Caleb, Khammanivong, Ali, Korpela, Derek M, Brown, David R, Taylor, Josephine, Bryan, Brad A, Dickerson, Erin B

“…Angiosarcoma is a rare cancer of blood vessel-forming cells with a high patient mortality and few treatment options. Although chemotherapy often produces…”
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Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth by Amaya, Clarissa N, Mitchell, Dianne C, Bryan, Brad A

“…The serine/threonine protein kinases ROCK1 and 2 are key RhoA-mediated regulators of cell shape and cytoskeletal dynamics. These proteins perform multiple…”
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Coordinated vascular endothelial growth factor expression and signaling during skeletal myogenic differentiation by Bryan, Brad A, Walshe, Tony E, Mitchell, Dianne C, Havumaki, Josh S, Saint-Geniez, Magali, Maharaj, Arindel S, Maldonado, Angel E, D'Amore, Patricia A

“…Angiogenesis is largely controlled by hypoxia-driven transcriptional up-regulation and secretion of vascular endothelial growth factor (VEGF) and its binding…”
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Anti-angiogenic therapy: Adapting strategies to overcome resistant tumors by Mitchell, Dianne C., Bryan, Brad A.

“…Healthy cells, as well as benign and malignant tumors, depend upon the body's blood supply to bring in oxygen and nutrients and carry away waste products…”
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The function of vascular endothelial growth factor by Nieves, Bonnie J., D'Amore, Patricia A., Bryan, Brad A.

“…Vascular endothelial growth factor (VEGF) is considered the master regulator of angiogenesis during growth and development, as well as in disease states such…”
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Everolimus affects vasculogenic mimicry in renal carcinoma resistant to sunitinib by Serova, Maria, Tijeras-Raballand, Annemilaï, Dos Santos, Celia, Martinet, Matthieu, Neuzillet, Cindy, Lopez, Alfred, Mitchell, Dianne C, Bryan, Brad A, Gapihan, Guillaume, Janin, Anne, Bousquet, Guilhem, Riveiro, Maria Eugenia, Bieche, Ivan, Faivre, Sandrine, Raymond, Eric, de Gramont, Armand

“…Angiogenesis is hallmark of clear cell renal cell carcinogenesis. Anti-angiogenic therapies have been successful in improving disease outcome; however, most…”
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Beta-adrenergic receptors are expressed across diverse cancers by Rains, Steven L., Amaya, Clarissa N., Bryan, Brad A.

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Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior by Scott, Milcah C, Tomiyasu, Hirotaka, Garbe, John R, Cornax, Ingrid, Amaya, Clarissa, O'Sullivan, M Gerard, Subramanian, Subbaya, Bryan, Brad A, Modiano, Jaime F

“…Osteosarcoma (OS) is a heterogeneous and rare disease with a disproportionate impact because it mainly affects children and adolescents. Lamentably, more than…”
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Modulation of Muscle Regeneration, Myogenesis, and Adipogenesis by the Rho Family Guanine Nucleotide Exchange Factor GEFT by Bryan, Brad A., Mitchell, Dianne C., Zhao, Lei, Ma, Wenbin, Stafford, Lewis J., Teng, Ba-Bie, Liu, Mingyao

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Growth Attenuation of Cutaneous Angiosarcoma With Propranolol-Mediated β-Blockade by Chow, William, Amaya, Clarissa N, Rains, Steven, Chow, Michael, Dickerson, Erin B, Bryan, Brad A

“…Patients with stage T2 multilesion angiosarcomas of the scalp and face that are larger than 10 cm demonstrate a 2-year survival rate of 0%. To our knowledge,…”
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Beta Adrenergic Signaling: A Targetable Regulator of Angiosarcoma and Hemangiosarcoma by Dickerson, Erin B, Bryan, Brad A

“…Human angiosarcomas and canine hemangiosarcomas are highly aggressive cancers thought to arise from cells of vascular origin. The pathological features,…”
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The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth by Bryan, Brad A., Cai, Yi, Liu, Mingyao

“…The Rho GTPases are important regulators of neurite outgrowth and pathfinding. We have recently reported that a Rho‐family guanine nucleotide exchange factor,…”
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PD-1 and PD-L1 expression in bone and soft tissue sarcomas by Torabi, Alireza, Amaya, Clarissa N., Wians, Frank H., Bryan, Brad A.

“…PD-1 and its ligands have been shown to play a significant role in evasion of malignant tumour cells from the immune system. Last year, the Unites States Food…”
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Rho Kinase Proteins-Pleiotropic Modulators of Cell Survival and Apoptosis by STREET, Catharine A, BRYAN, Brad A

“…Rho kinase (ROCK) proteins are Rho-GTPase activated serine/threonine kinases that function as modulators of actin-myosin cytoskeletal dynamics via regulation…”
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GPR126 Protein Regulates Developmental and Pathological Angiogenesis through Modulation of VEGFR2 Receptor Signaling by Cui, Hengxiang, Wang, Yeqi, Huang, Huizhe, Yu, Wenjie, Bai, Min, Zhang, Long, Bryan, Brad A., Wang, Yuan, Luo, Jian, Li, Dali, Ma, Yanlin, Liu, Mingyao

“…Angiogenesis, the formation of new blood vessels from pre-existing ones, is essential for development, wound healing, and tumor progression. The VEGF pathway…”
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Use of non-selective β-blockers is associated with decreased tumor proliferative indices in early stage breast cancer by Montoya, Alexa, Amaya, Clarissa N, Belmont, Andres, Diab, Nabih, Trevino, Richard, Villanueva, Geri, Rains, Steven, Sanchez, Luis A, Badri, Nabeel, Otoukesh, Salman, Khammanivong, Ali, Liss, Danielle, Baca, Sarah T, Aguilera, Renato J, Dickerson, Erin B, Torabi, Alireza, Dwivedi, Alok K, Abbas, Aamer, Chambers, Karinn, Bryan, Brad A, Nahleh, Zeina

“…Previous studies suggest beta-adrenergic receptor (β-AR) antagonists (β-blockers) decrease breast cancer progression, tumor metastasis, and patient mortality;…”
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A patient organization perspective: charting the course to a cure for SCN2A-related disorders by Schust, Leah F., Burke, Jennifer, SanInocencio, Christina, Bryan, Brad A., Ho, Karen S., Egan, Shawn M.

“…The SCN2A gene encodes the Nav1.2 protein, a voltage-gated sodium channel crucial for initiating and transmitting action potentials in neurons. Dysfunction in…”
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Activity of 2‑Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells by Aksenov, Alexander V, Smirnov, Alexander N, Magedov, Igor V, Reisenauer, Mary R, Aksenov, Nicolai A, Aksenova, Inna V, Pendleton, Alexander L, Nguyen, Gina, Johnston, Robert K, Rubin, Michael, De Carvalho, Annelise, Kiss, Robert, Mathieu, Véronique, Lefranc, Florence, Correa, Jaime, Cavazos, David A, Brenner, Andrew J, Bryan, Brad A, Rogelj, Snezna, Kornienko, Alexander, Frolova, Liliya V

“…Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to…”
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