Search Results - "Bruyns, E."

Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression by SCHMITT, R. M, BRUYNS, E, SNODGRASS, H. R

“…A novel system to study early hematopoietic development is described. This report documents the in vitro capacity of murine embryonic stem (ES) cells to…”
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LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes by Schraven, B, Schoenhaut, D, Bruyns, E, Koretzky, G, Eckerskorn, C, Wallich, R, Kirchgessner, H, Sakorafas, P, Labkovsky, B, Ratnofsky, S

“…CD45, a leukocyte-specific protein tyrosine phosphatase involved in signal transduction, has previously been shown to associate with a 32-kDa phosphoprotein in…”
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Biochemical analysis of the CD45-p56(lck) complex in Jurkat T cells lacking expression of lymphocyte phosphatase-associated phosphoprotein by Bruyns, E, Kirchgessner, H, Meuer, S, Schraven, B

“…In human and mouse lymphocytes the protein tyrosine phosphatase CD45, a key molecule involved in T cell activation, non-covalently associates with the tyrosine…”
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Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT) by Hübener, C, Mincheva, A, Lichter, P, Schraven, B, Bruyns, E

“…In the present study, we isolated the SIT gene from a human P-1-derived atificial chromosome (PAC) library and determined the exon-intron junctions. We…”
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Developmentally Regulated Expression of the Transmembrane Adaptor Protein TRIM in Fetal and Adult T Cells by Huynh, T., Würch, A., Bruyns, E., Korinek, V., Schraven, B., Eichmann, K.

“…TRIM is a recently identified transmembrane adaptor protein which is exclusively expressed in T cells and natural killer (NK) cells. In peripheral blood T…”
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Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM) by Hübener, C, Mincheva, A, Lichter, P, Schraven, B, Bruyns, E

“…The primary signal for human T-cell activation is mediated through the interaction of the polymorphic T-cell receptor (TCR) with its natural ligand, antigenic…”
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Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation by Brdicka, T, Pavlistová, D, Leo, A, Bruyns, E, Korínek, V, Angelisová, P, Scherer, J, Shevchenko, A, Hilgert, I, Cerný, J, Drbal, K, Kuramitsu, Y, Kornacker, B, Horejsí, V, Schraven, B

“…According to a recently proposed hypothesis, initiation of signal transduction via immunoreceptors depends on interactions of the engaged immunoreceptor with…”
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The Transmembrane Adapter Protein SIT Regulates Thymic Development and Peripheral T-Cell Functions by Simeoni, Luca, Posevitz, Vilmos, Kölsch, Uwe, Meinert, Ines, Bruyns, Eddy, Pfeffer, Klaus, Reinhold, Dirk, Schraven, Burkhart

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T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane by Bruyns, E, Marie-Cardine, A, Kirchgessner, H, Sagolla, K, Shevchenko, A, Mann, M, Autschbach, F, Bensussan, A, Meuer, S, Schraven, B

“…The molecular mechanisms regulating recruitment of intracellular signaling proteins like growth factor receptor-bound protein 2 (Grb2), phospholipase Cgamma1,…”
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Normal T-Cell Development and Immune Functions in TRIM-Deficient Mice by Kölsch, Uwe, Arndt, Börge, Reinhold, Dirk, Lindquist, Jonathan A., Jüling, Nicole, Kliche, Stefanie, Pfeffer, Klaus, Bruyns, Eddy, Schraven, Burkhart, Simeoni, Luca

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Molecular Cloning of SKAP55, a Novel Protein That Associates with the Protein Tyrosine Kinase p59 in Human T-lymphocytes by Marie-Cardine, Anne, Bruyns, Eddy, Eckerskorn, Christoph, Kirchgessner, Henning, Meuer, Stefan C., Schraven, Burkhart

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The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain by Kirchgessner, H, Dietrich, J, Scherer, J, Isomäki, P, Korinek, V, Hilgert, I, Bruyns, E, Leo, A, Cope, A P, Schraven, B

“…T cell receptor (TCR)-interacting molecule (TRIM) is a recently identified transmembrane adaptor protein, which is exclusively expressed in T cells. Here we…”
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SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation by Marie-Cardine, A, Kirchgessner, H, Bruyns, E, Shevchenko, A, Mann, M, Autschbach, F, Ratnofsky, S, Meuer, S, Schraven, B

“…T lymphocytes express several low molecular weight transmembrane adaptor proteins that recruit src homology (SH)2 domain-containing intracellular molecules to…”
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Major haemorrhage in Crohn's disease by Bruyns, E, Lubbers, E J, Van Tongeren, J H

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Driving competence of the elderly with cognitive problems. Assessment and recommendations by Veen, C, Bruyns, E

“…The case histories of five patients with cognitive disorders are presented and the policy in the assessment of driving performance is discussed. In accordance…”
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Biochemical and functional analysis of mice deficient in expression of the CD45‐associated phosphoprotein LPAP by Ding, Isabelle, Bruyns, Eddy, Li, Ping, Magada, Diane, Paskind, Michael, Rodman, Laura, Seshadri, Tara, Alexander, Denis, Giese, Thomas, Schraven, Burkhart

“…The role of the CD45‐associated phosphoprotein (LPAP / CD45‐AP) during an immune response remains unclear. To understand better the function of LPAP we…”
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Biochemical analysis of the CD45-p56 super(lck) complex in Jurkat T cells lacking expression of lymphocyte phosphatase-associated phosphoprotein by Bruyns, E, Kirchgessner, H, Meuer, S, Schraven, B

“…In human and mouse lymphocytes the protein tyrosine phosphatase CD45, a key molecule involved in T cell activation, non-covalently associates with the tyrosine…”
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Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP by Ding, I, Bruyns, E, Li, P, Magada, D, Paskind, M, Rodman, L, Seshadri, T, Alexander, D, Giese, T, Schraven, B

“…The role of the CD45-associated phosphoprotein (LPAP/CD45-AP) during an immune response remains unclear. To understand better the function of LPAP we generated…”
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Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes by Marie-Cardine, A, Bruyns, E, Eckerskorn, C, Kirchgessner, H, Meuer, S C, Schraven, B

“…In human T-lymphocytes the Src family protein tyrosine kinase p59(fyn) associates with three phosphoproteins of 43, 55, and 85 kDa (pp43, pp55, and pp85)…”
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Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59 super(fyn) in human T-lymphocytes by Marie-Cardine, A, Bruyns, E, Eckerskorn, C, Kirchgessner, H, Meuer, S C, Schraven, B

“…In human T-lymphocytes the Src family protein tyrosine kinase p59 super(fyn) associates with three phosphoproteins of 43, 55, and 85 kDa (pp43, pp55, and…”
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