Search Results - "Bruton, J D"

Prolonged force increase following a high-frequency burst is not due to a sustained elevation of [Ca2+]i by Abbate, F, Bruton, J D, De Haan, A, Westerblad, H

“…A brief high-frequency burst of action potentials results in a sustained force increase in skeletal muscle. The present study investigates whether this force…”
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The effect of intracellular pH on contractile function of intact, single fibres of mouse muscle declines with increasing temperature by Westerblad, H, Bruton, J D, Lännergren, J

“…1. The effect of altered intracellular pH (pHi) on isometric contractions and shortening velocity at 12, 22 and 32 degrees C was studied in intact, single…”
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Activation of Ca(2+)-dependent protein kinase II during repeated contractions in single muscle fibres from mouse is dependent on the frequency of sarcoplasmic reticulum Ca(2+) release by Aydin, J, Korhonen, T, Tavi, P, Allen, D G, Westerblad, H, Bruton, J D

“…To investigate the importance and contribution of calmodulin-dependent protein kinase II (CaMKII) activity on sarcoplasmic reticulum (SR) Ca(2+)-release in…”
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Mechanisms underlying the reduction of isometric force in skeletal muscle fatigue by WESTERBLAD, H., ALLEN, D. G., BRUTON, J. D., ANDRADE, F. H., LÄNNERGREN, J.

“…A decline of isometric force production is one characteristic of skeletal muscle fatigue. In fatigue produced by repeated short tetani, this force decline can…”
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Vacuole formation in fatigued skeletal muscle fibres from frog and mouse: effects of extracellular lactate by Lännergren, Jan, Bruton, Joseph D., Westerblad, Håkan

“…Isolated, living muscle fibres from either Xenopus or mouse were observed in a confocal microscope and t-tubules were visualized with sulforhodamine B…”
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Increased tetanic force and reduced myoplasmic [P(i)] following a brief series of tetani in mouse soleus muscle by Bruton, J D, Wretman, C, Katz, A, Westerblad, H

“…Muscle performance is improved after a brief period of exercise (warm-up). One factor that is known to strongly affect force production is the myoplasmic…”
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Mechano-sensitive linkage in excitation-contraction coupling in frog skeletal muscle by Bruton, J D, Lännergren, J, Westerblad, H

“…1. Single skeletal muscle fibres of Xenopus laevis were used to investigate the involvement of a mechano-sensitive link in excitation-contraction coupling (EC…”
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Mechanisms underlying the slow recovery of force after fatigue: importance of intracellular calcium by BRUTON, J. D., LÄNNERGREN, J., WESTERBLAD, H.

“…Recovery of force production after an intense bout of activity may sometimes take several days, especially at low activation frequencies ('low frequency…”
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The role of Ca2+ and calmodulin in insulin signalling in mammalian skeletal muscle by Bruton, J. D., Katz, A., Westerblad, H.

“…The role of Ca2+ in mediating effects of insulin on skeletal muscle has been widely debated. It is believed that in skeletal muscle Ca2+ has a permissive role,…”
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Functional significance of Ca2+ in long-lasting fatigue of skeletal muscle by Westerblad, H, Bruton, J D, Allen, D G, Lännergren, J

“…Repeated activation of skeletal muscle causes fatigue, which involves a reduced ability to produce force and slowed contraction regarding both the speed of…”
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Activation of Ca²⁺-dependent protein kinase II during repeated contractions in single muscle fibres from mouse is dependent on the frequency of sarcoplasmic reticulum Ca²⁺ release by Aydin, J, Korhonen, T, Tavi, P, Allen, D.G, Westerblad, H, Bruton, J.D

“…To investigate the importance and contribution of calmodulin-dependent protein kinase II (CaMKII) activity on sarcoplasmic reticulum (SR) Ca²⁺-release in…”
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Effects of a myosin-II inhibitor (N-benzyl-p-toluene sulphonamide, BTS) on contractile characteristics of intact fast-twitch mammalian muscle fibres by Pinniger, G J, Bruton, J D, Westerblad, H, Ranatunga, K W

“…We have examined the effects of N-benzyl-p-toluene sulphonamide (BTS), a potent and specific inhibitor of fast muscle myosin-II, using small bundles of intact…”
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Effects of repetitive tetanic stimulation at long intervals on excitation-contraction coupling in frog skeletal muscle by Bruton, J D, Lännergren, J, Westerblad, H

“…1. Single skeletal muscle fibres of Xenopus frogs were used to investigate the possibility that excitation-contraction (E-C) coupling can be impaired under…”
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Slow recovery of force in single skeletal muscle fibres by Lännergren, J, Westerblad, H, Bruton, J D

“…After a bout of intense exercise, especially in untrained persons recovery of muscle force is often slow. Force depression is much more marked at low…”
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Augmented force output in skeletal muscle fibres of Xenopus following a preceding bout of activity by Bruton, J D, Westerblad, H, Katz, A, Lännergren, J

“…1. The effect of a brief period of activity on subsequent isometric tetanic force production was investigated in single muscle fibres of Xenopus laevis. 2…”
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Role of chloride in hypertonicity-induced contractures of rat soleus muscle by Bruton, J D

“…The role of chloride in contractures induced in rat soleus muscle by mannitol-, sucrose- or urea-containing hypertonic solutions was investigated. Replacement…”
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Effects of CO2-induced acidification on the fatigue resistance of single mouse muscle fibers at 28 degrees C by Bruton, J D, Lännergren, J, Westerblad, H

“…The role of reduced muscle pH in the development of skeletal muscle fatigue is unclear. This study investigated the effects of lowering skeletal muscle…”
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Contraction and intracellular Ca(2+) handling in isolated skeletal muscle of rats with congestive heart failure by Lunde, P K, Dahlstedt, A J, Bruton, J D, Lännergren, J, Thorén, P, Sejersted, O M, Westerblad, H

“…A decreased exercise tolerance is a common symptom in patients with congestive heart failure (CHF). This decrease has been suggested to be partly due to…”
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Reversible depression of action potentials and force production in frog single muscle fibres by calmodulin-inhibitors by Bruton, J D, Westerblad, H, Lännergren, J

“…The effects of the calmodulin-inhibitors trifluoperazine, thioridazine and zaldaride maleate on the responses to electrical stimulation in isolated frog…”
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Lipase inhibitors abolish contractions and cause depolarization in frog skeletal muscle fibres by Bruton, J D, Westerblad, H, Lännergren, J

“…Single, intact frog muscle fibers were exposed to bromophenylacylbromide (BPB) or nordihydroguairetic acid (NDGA). Fibres first became unable to respond to…”
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