Unusual Presentation of Life-Threatening Toscana Virus Meningoencephalitis

This case report describes a brother and a sister with severe meningoencephalitis caused by Toscana virus (TOSv). The clinical presentation was characterized by stiff neck, deep coma, maculopapular rash, diffuse lymphadenopathy, hepatosplenomegaly, renal involvement, tendency to bleeding, and diffus...

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Bibliographic Details
Published in:	Clinical infectious diseases Vol. 38; no. 4; pp. 515 - 520
Main Authors:	Baldelli, Franco, Ciufolini, Maria Grazia, Francisci, Daniela, Marchi, Antonella, Venturi, Giulietta, Fiorentini, Cristiano, Luchetta, Maria Laura, Bruto, Lidia, Pauluzzi, Sergio
Format:	Journal Article
Language:	English
Published:	Chicago, IL The University of Chicago Press 15-02-2004 University of Chicago Press
Subjects:	Adolescent Adult Amino acids Antibodies Biological and medical sciences Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Exanthema Female Fever Hematologic and hematopoietic diseases Humans Infections Major Articles Male Medical sciences Meningoencephalitis Meningoencephalitis - physiopathology Meningoencephalitis - virology Nervous system (semeiology, syndromes) Neurology Phlebotomus fever Phlebotomus Fever - physiopathology Phlebotomus Fever - virology Platelet diseases and coagulopathies Polymerase chain reaction RNA, Viral - analysis Sandfly fever Naples virus Sandfly fever Naples virus - genetics Sandfly fever Naples virus - immunology Sandfly fever Naples virus - isolation & purification Serologic Tests Toscana virus Viruses Italy Coma RNA-directed DNA polymerase Hemopathy Hemorrhage Kidney Neck Diagnosis Neurological disorder Hydrocephaly Child Sequencing Epididymo-orchitis Human Nervous system diseases Disseminated intravascular coagulopathy Nucleotide sequence Enzyme Critically ill Transferases Consciousness impairment Cerebral disorder Meningoencephalitis Case study Polymerase chain reaction Virus Symptomatology Nucleotidyltransferases Adenopathy Central nervous system disease Molecular biology Coagulopathy
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Summary:	This case report describes a brother and a sister with severe meningoencephalitis caused by Toscana virus (TOSv). The clinical presentation was characterized by stiff neck, deep coma, maculopapular rash, diffuse lymphadenopathy, hepatosplenomegaly, renal involvement, tendency to bleeding, and diffuse intravascular coagulation. The boy had epididymo-orchitis. Recovery with neurologic sequelae as hydrocephalus was observed. Microbiological diagnosis was obtained by serological tests and reverse transcriptase-polymerase chain reaction. Sequencing of polymerase chain reaction products from the S and M segments was carried out. TOSv may be a causative agent in severe meningoencephalitis.
Bibliography:	ark:/67375/HXZ-3W9RSZ3X-R istex:DB9F5D31106E88D61FF8C3DEBC509AD01E4994F5 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1058-4838 1537-6591
DOI:	10.1086/381201