Search Results - "Brutkiewicz, R R"

CD1d Ligands: The Good, the Bad, and the Ugly by Brutkiewicz, Randy R

“…The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of…”
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The Complexity of Microglial Interactions With Innate and Adaptive Immune Cells in Alzheimer's Disease by Wyatt-Johnson, Season K, Brutkiewicz, Randy R

“…In the naïve mouse brain, microglia and astrocytes are the most abundant immune cells; however, there is a complexity of other immune cells present including…”
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CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis by Hix, Laura M, Shi, Yihui H, Brutkiewicz, Randy R, Stein, Paul L, Wang, Chyung-Ru, Zhang, Ming

“…Tumor tolerance and immune suppression remain formidable obstacles to the efficacy of immunotherapies that harness the immune system to eradicate breast…”
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Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d‐specific ligands for NKT cells by Sriram, Venkataraman, Du, Wenjun, Gervay‐Hague, Jacquelyn, Brutkiewicz, Randy R.

“…The current consensus on characterization of NKT cells is based on their reactivity to the synthetic glycolipid, α‐galactosylceramide (α‐GalCer) in a…”
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Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis by Wyatt-Johnson, Season K, Kersey, Holly N, Codocedo, Juan F, Newell, Kathy L, Landreth, Gary E, Lamb, Bruce T, Oblak, Adrian L, Brutkiewicz, Randy R

“…Neuroinflammation is an important feature of Alzheimer's disease (AD). Understanding which aspects of the immune system are important in AD may lead to new…”
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Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma by Renukaradhya, Gourapura J., Khan, Masood A., Vieira, Marcus, Du, Wenjun, Gervay-Hague, Jacquelyn, Brutkiewicz, Randy R.

“…Natural killer T (NKT) cells are a T-cell subpopulation known to possess immunoregulatory functions and recognize CD1d molecules. The majority of NKT cells…”
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Genetic engineering of porcine endothelial cell lines for evaluation of human-to-pig xenoreactive immune responses by Li, Ping, Walsh, Julia R., Lopez, Kevin, Isidan, Abdulkadir, Zhang, Wenjun, Chen, Angela M., Goggins, William C., Higgins, Nancy G., Liu, Jianyun, Brutkiewicz, Randy R., Smith, Lester J., Hara, Hidetaka, Cooper, David K. C., Ekser, Burcin

“…Xenotransplantation (cross-species transplantation) using genetically-engineered pig organs offers a potential solution to address persistent organ shortage…”
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Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses by Webb, Tonya J., Carey, Gregory B., East, James E., Sun, Wenji, Bollino, Dominique R., Kimball, Amy S., Brutkiewicz, Randy R.

“…Natural killer T (NKT) cells play a critical role in the host's innate immune response. CD1d-mediated presentation of glycolipid antigens to NKT cells has been…”
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An efferocytosis-induced, IL-4–dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD by Zeng, Melody Yue, Pham, Duy, Bagaitkar, Juhi, Liu, Jianyun, Otero, Karel, Shan, Ming, Wynn, Thomas A., Brombacher, Frank, Brutkiewicz, Randy R., Kaplan, Mark H., Dinauer, Mary C.

“…Efferocytosis of apoptotic neutrophils by macrophages following tissue injury is fundamental to the resolution of inflammation and initiation of tissue repair…”
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Publisher Correction: Genetic engineering of porcine endothelial cell lines for evaluation of human-to-pig xenoreactive immune responses by Li, Ping, Walsh, Julia R., Lopez, Kevin, Isidan, Abdulkadir, Zhang, Wenjun, Chen, Angela M., Goggins, William C., Higgins, Nancy G., Liu, Jianyun, Brutkiewicz, Randy R., Smith, Lester J., Hara, Hidetaka, Cooper, David K. C., Ekser, Burcin

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Lamp-2a Facilitates MHC Class II Presentation of Cytoplasmic Antigens by Zhou, Delu, Li, Ping, Lin, Yinling, Lott, Jeremy M., Hislop, Andrew D., Canaday, David H., Brutkiewicz, Randy R., Blum, Janice S.

“…Extracellular antigens are internalized and processed before binding MHC class II molecules within endosomal and lysosomal compartments of professional antigen…”
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Natural Ligand of Mouse CD1d1: Cellular Glycosylphosphatidylinositol by Joyce, Sebastian, Woods, Amina S., Yewdell, Jonathan W., Bennink, Jack R., de Silva, A. Dharshan, Boesteanu, Alina, Balk, Steven P., Cotter, Robert J., Brutkiewicz, Randy R.

“…Mouse CD1d1, a member of the CD1 family of evolutionarily conserved major histocompatibility antigen-like molecules, controls the differentiation and function…”
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Sex discrepancy in the reduction of mucosal‐associated invariant T cells caused by obesity by Liu, Jianyun, Nan, Hongmei, Brutkiewicz, Randy R, Casasnovas, Jose, Kua, Kok Lim

“…Introduction Gut microbiota has been reported to contribute to obesity and the pathology of obesity‐related diseases but the underlying mechanisms are largely…”
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Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma by Liu, Jianyun, Gallo, Richard M, Khan, Masood A, Renukaradhya, Gourapura J, Brutkiewicz, Randy R

“…Neurofibromin 1 (NF1) is a tumor suppressor gene encoding a Ras GTPase that negatively regulates Ras signaling pathways. Mutations in NF1 are linked to…”
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CD1 Recognition by Mouse NK1$^+$ T Lymphocytes by Bendelac, Albert, Lantz, Olivier, Quimby, Mary E., Yewdell, Jonathan W., Bennink, Jack R., Brutkiewicz, Randy R.

“…Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these…”
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Critical Role of NKT Cells in Posttransplant Alloantibody Production by Zimmerer, J. M., Swamy, P., Sanghavi, P. B., Wright, C. L., Abdel‐Rasoul, M., Elzein, S. M., Brutkiewicz, R. R., Bumgardner, G. L.

“…We previously reported that posttransplant alloantibody production in CD8‐deficient hosts is IL‐4+CD4+ T cell–dependent and IgG1 isotype‐dominant. The current…”
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Cell Signaling Pathways That Regulate Antigen Presentation by Brutkiewicz, Randy R

“…Cell signaling pathways regulate much in the life of a cell: from shuttling cargo through intracellular compartments and onto the cell surface, how it should…”
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Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex by Cho, Sungyoo, Knox, Kenneth S., Kohli, Lisa M., He, Johnny J., Exley, Mark A., Wilson, S. Brian, Brutkiewicz, Randy R.

“…The HIV-1 Nef protein causes a decrease in major histocompatibility complex (MHC) class I and CD4 molecule expression on the cell surface. To determine if Nef…”
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Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d by Gallo, Richard M, Khan, Masood A, Shi, Jianjian, Kapur, Reuben, Wei, Lei, Bailey, Jennifer C, Liu, Jianyun, Brutkiewicz, Randy R

“…CD1d molecules are MHC class I-like molecules that present lipid Ags to NKT cells. Although we have previously shown that several different cell signaling…”
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Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype by Yeh, Norman, Glosson, Nicole L, Wang, Nan, Guindon, Lynette, McKinley, Carl, Hamada, Hiromasa, Li, Qingsheng, Dutton, Richard W, Shrikant, Protul, Zhou, Baohua, Brutkiewicz, Randy R, Blum, Janice S, Kaplan, Mark H

“…CD8 T cells can acquire cytokine-secreting phenotypes paralleling cytokine production from Th cells. IL-17-secreting CD8 T cells, termed Tc17 cells, were shown…”
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