Search Results - "Bruter, Alexandra V."

Key Proteins of Replication Stress Response and Cell Cycle Control as Cancer Therapy Targets by Khamidullina, Alvina I, Abramenko, Yaroslav E, Bruter, Alexandra V, Tatarskiy, Victor V

“…Replication stress (RS) is a characteristic state of cancer cells as they tend to exchange precision of replication for fast proliferation and increased…”
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CD52/FLAG and CD52/HA Fusion Proteins as Novel Magnetic Cell Selection Markers by Kandarakov, Oleg F, Polyakova, Natalia S, Petrovskaya, Alexandra V, Bruter, Alexandra V, Belyavsky, Alexander V

“…At present, the magnetic selection of genetically modified cells is mainly performed with surface markers naturally expressed by cells such as CD4, LNGFR (low…”
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Genetically Engineered Mice Unveil In Vivo Roles of the Mediator Complex by Ilchuk, Leonid A, Kubekina, Marina V, Okulova, Yulia D, Silaeva, Yulia Yu, Tatarskiy, Victor V, Filatov, Maxim A, Bruter, Alexandra V

“…The Mediator complex is a multi-subunit protein complex which plays a significant role in the regulation of eukaryotic gene transcription. It provides a…”
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Limitations of Tamoxifen Application for In Vivo Genome Editing Using Cre/ERT2 System by Ilchuk, Leonid A., Stavskaya, Nina I., Varlamova, Ekaterina A., Khamidullina, Alvina I., Tatarskiy, Victor V., Mogila, Vladislav A., Kolbutova, Ksenia B., Bogdan, Sergey A., Sheremetov, Alexey M., Baulin, Alexandr N., Filatova, Irina A., Silaeva, Yulia Yu, Filatov, Maxim A., Bruter, Alexandra V.

“…Inducible Cre-dependent systems are frequently used to produce both conditional knockouts and transgenic mice with regulated expression of the gene of…”
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Gene Transcription as a Therapeutic Target in Leukemia by Khamidullina, Alvina I., Varlamova, Ekaterina A., Hammoud, Nour Alhuda, Yastrebova, Margarita A., Bruter, Alexandra V.

“…Blood malignancies often arise from undifferentiated hematopoietic stem cells or partially differentiated stem-like cells. A tight balance of multipotency and…”
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Physiological and Functional Effects of Dominant Active TCRα Expression in Transgenic Mice by Kalinina, Anastasiia A, Ziganshin, Rustam Kh, Silaeva, Yulia Yu, Sharova, Nina I, Nikonova, Margarita F, Persiyantseva, Nadezda A, Gorkova, Tatiana G, Antoshina, Elena E, Trukhanova, Lubov S, Donetskova, Almira D, Komogorova, Victoria V, Litvina, Marina M, Mitin, Alexander N, Zamkova, Maria A, Bruter, Alexandra V, Khromykh, Ludmila M, Kazansky, Dmitry B

“…A T cell receptor (TCR) consists of α- and β-chains. Accumulating evidence suggests that some TCRs possess chain centricity, i.e., either of the hemi-chains…”
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On the way from SARS-CoV-sensitive mice to murine COVID-19 model by Soldatov, Vladislav O., Kubekina, Marina V., Silaeva, Yuliya Yu, Bruter, Alexandra V., Deykin, Alexey V.

“…The coronavirus disease 2019 (COVID-19) is a master killer which appeared suddenly and which has already claimed more than 200,000 human lives. In this…”
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Adoptive Immunotherapy Based on Chain-Centric TCRs in Treatment of Infectious Diseases by Kalinina, Anastasiia A., Nesterenko, Ludmila N., Bruter, Alexandra V., Balunets, Denis V., Chudakov, Dmitriy M., Izraelson, Mark, Britanova, Olga V., Khromykh, Ludmila M., Kazansky, Dmitry B.

“…Complications after vaccination, lack of vaccines against certain infections, and the emergence of antibiotic-resistant microorganisms point to the need for…”
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Anti-Cancer Potential of Transiently Transfected HER2-Specific Human Mixed CAR-T and NK Cell Populations in Experimental Models: Initial Studies on Fucosylated Chondroitin Sulfate Usage for Safer Treatment by Chikileva, Irina O, Bruter, Alexandra V, Persiyantseva, Nadezhda A, Zamkova, Maria A, Vlasenko, Raimonda Ya, Dolzhikova, Yuliya I, Shubina, Irina Zh, Donenko, Fedor V, Lebedinskaya, Olga V, Sokolova, Darina V, Pokrovsky, Vadim S, Fedorova, Polina O, Ustyuzhanina, Nadezhda E, Anisimova, Natalia Yu, Nifantiev, Nikolay E, Kiselevskiy, Mikhail V

“…Human epidermal growth factor receptor 2 (HER2) is overexpressed in numerous cancer cell types. Therapeutic antibodies and chimeric antigen receptors (CARs)…”
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Transgenic mice Cre-dependently expressing mutant polymerase-gamma: novel test-system for pharmacological study of mitoprotective drugs by Kubekina, Marina V., Silaeva, Yulia Yu, Bruter, Alexandra V., Korshunova, Diana S., Ilchuk, Leonid A., Okulova, Yulia D., Soldatova, Mariya O., Seryogina, Evgeniya, Kolesnik, Inga M., Ukolova, Polina A., Korokin, Mikhail V., Deykin, Alexey V.

“…Introduction: PolG-alpha is a nuclear-encoded enzyme which provides replication and repair of mitochondrial DNA. D257A mutation of PolG-alpha leads to change…”
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Gene editing CRISPR/Cas9 system for producing cows with hypoallergenic milk on the background of a beta-lactoglobulin gene knockout by Silaeva, Yulia Yu, Kubekina, Marina V., Bruter, Alexandra V., Isaeva, Albina G., Koshchaev, Andrey G.

“…Beta-lactoglobulin is the main allergen of cow’s milk. Modern approaches to reducing the allergenicity of milk require significant costs for its fermentation…”
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Production of hornless dairy cattle from genome-edited blastocysts by Deykin, Alexey V., Bruter, Alexandra V., Krivonogova, Anna S., Shepelev, Mikhail V., Koshchaev, Andrey G.

“…Cattle of polled phenotype is convenient for breeders, as it decreases the risk of animals being hurt and ensures safety of workers. We developed the system…”
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Genetically modified mice as a tool for the study of human diseases by Bruter, Alexandra V., Varlamova, Ekaterina A., Okulova, Yulia D., Tatarskiy, Victor V., Silaeva, Yulia Y., Filatov, Maxim A.

“…Modeling a human disease is an essential part of biomedical research. The recent advances in the field of molecular genetics made it possible to obtain…”
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AAV infection of bovine embryos: Novel, simple and effective tool for genome editing by Krivonogova, Anna S., Bruter, Alexandra V., Makutina, Valeria A., Okulova, Yuliya D., Ilchuk, Leonid A., Kubekina, Marina V., Khamatova, Alexandra Yu, Egorova, Tatiana V., Mymrin, Vladimir S., Silaeva, Yuliya Yu, Deykin, Alexey V., Filatov, Maxim A., Isaeva, Albina G.

“…Adeno-associated viruses (AAV) are widely used in the field of genetically modified organism production. In this work, transduction of bovine embryos by AAV…”
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Persistence of plasmid‐mediated expression of transgenes in human mesenchymal stem cells depends primarily on CpG levels of both vector and transgene by Bruter, Alexandra V., Kandarakov, Oleg F., Belyavsky, Alexander V.

“…Background Gene therapy and cell modification for clinical applications using plasmid vectors are considered to be a safe and promising strategy. One of the…”
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Novel transgenic mice with Cre-dependent co-expression of GFP and human ACE2: a safe tool for study of COVID-19 pathogenesis by Bruter, Alexandra V., Korshunova, Diana S., Kubekina, Marina V., Sergiev, Petr V., Kalinina, Anastasiia A., Ilchuk, Leonid A., Silaeva, Yuliya Yu, Korshunov, Eugenii N., Soldatov, Vladislav O., Deykin, Alexey V.

“…The current coronavirus disease (COVID-19) pandemic remains one of the most serious public health problems. Increasing evidence shows that infection by severe…”
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Super-Enhancers in the Regulation of Gene Transcription: General Aspects and Antitumor Targets by Bruter, A V, Rodionova, M D, Varlamova, E A, Shtil, A A

“…Super-enhancers (genome elements that activate gene transcription) are DNA regions with an elevated concentration of transcriptional complexes. These…”
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Limitations of Tamoxifen Application for In Vivo Genome Editing Using Cre/ER T2 System by Ilchuk, Leonid A, Stavskaya, Nina I, Varlamova, Ekaterina A, Khamidullina, Alvina I, Tatarskiy, Victor V, Mogila, Vladislav A, Kolbutova, Ksenia B, Bogdan, Sergey A, Sheremetov, Alexey M, Baulin, Alexandr N, Filatova, Irina A, Silaeva, Yulia Yu, Filatov, Maxim A, Bruter, Alexandra V

“…Inducible Cre-dependent systems are frequently used to produce both conditional knockouts and transgenic mice with regulated expression of the gene of…”
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